Navigation Links
Gene Therapy For Parkinson's Disease Moves Forward In Animals

An international team of scientists has used gene therapy in two separate studies to renew brain cells and restore normal movements in monkeys and rats with a drug-induced form of Parkinson's disease.

The research, detailed online in the scientific publications Brain and The Journal of Neuroscience, essentially describes one strategy to halt Parkinson's disease at its onset and another strategy to treat the devastating side effects that occur when treating the disease in its later stages.

By inserting corrective genes into the brain, scientists studying small monkeys called marmosets prevented brain damage by producing therapeutic levels of a protein that helps nourish brain cells, said Ron Mandel, Ph.D., a scientist with the University of Florida's McKnight Brain Institute and Genetics Institute who was part of the research team.

The protein, called GDNF, short for glial cell line-derived neurotrophic factor, is believed to preserve brain cells and could provide protection against Parkinson's disease. But its use has been debated since trials in humans ended last year without showing clinical improvements. Amgen, the world's largest biotechnology company, conducted the trials and later halted use of the drug because of safety concerns, creating an outcry from hopeful Parkinson's patients.

But the gene therapy used in monkeys represents a different way to deliver the GDNF to the brain, causing the body to produce it naturally. It also produces more manageable levels of the protein in the brain.

“Our strategy is a neuroprotective concept and would only be amenable for early stage patients to keep a good quality of life. It would be a huge change in the way treatment is done,?said Mandel, a neuroscientist in UF's College of Medicine. “We know the GDNF protects the neurons in primates from the model that we use, so that's good. We now know we can use very low doses that are still effective, so that's good. But we need a safety net
'"/>

Source:University Of Florida Health Science Center


Page: 1 2 3 4

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
3. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
4. Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
5. Discovery Promises Simpler Therapy for Sickle Cell Disease
6. Gene Therapy Cures Inherited Liver Disease In Rats
7. Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants
8. HIV Therapy Greatly Extends Life of Key T Cells, Scientists Find
9. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
10. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
11. Scientists detect probable genetic cause of some Parkinsons disease cases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene Therapy For Parkinson Disease Moves Forward Animals

(Date:7/28/2014)... cure for Alzheimer,s disease and other forms of dementia, ... finding treatment. , University of Washington bioengineers have a ... changes of the body,s normal proteins into a state ... heart disease, Type 2 diabetes and Lou Gehrig,s disease. ... from their normal state into an abnormally folded form ...
(Date:7/28/2014)... Jude Children,s Research Hospital study found that 73 percent ... their risk of developing metabolic syndrome and related health ... results appear in the current issue of the journal ... 1,598 adult survivors of childhood cancer in the study ... factors like high blood pressure, abdominal obesity, elevated triglyceride ...
(Date:7/28/2014)... -- Research and Markets has announced the ... 2014-2018" report to their offering. ... analyze biological data. These systems capture biological traits such ... and hand measurements from the subject and compare the ... purpose of a biometrics system is to identify and ...
Breaking Biology News(10 mins):New protein structure could help treat Alzheimer's, related diseases 2New protein structure could help treat Alzheimer's, related diseases 3Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3Biometrics Market in Latin America 2014-2018 2
... Chemotherapy drugs, given intravenously, are the mainstay of the ... drugs effect a complete cure, while other times they ... those failures into successes? A team of scientists at ... the Biological Regulation Department, has come up with a ...
... Medicine studies of Hispanic farmworkers in North Carolina found that ... and that workers need more information about how to prevent ... as skin cancer. , Few studies have evaluated skin disease ... 59 farmworkers from Nash and Johnston Counties were examined by ...
... A promising new technique to ensure complete tumor removal ... issue of Radiology. , Researchers used light waves in ... region--to examine excised breast tissue and determine if the ... results. This technology has the potential to eliminate the ...
Cached Biology News:Predicting success 2Skin disease common among Hispanic farmworkers in North Carolina, research shows 2Terahertz imaging may reduce breast cancer surgeries 2
(Date:7/28/2014)... July 28, 2014  InterMune, Inc. (NASDAQ: ... second quarter 2014 financial results at the close of ... conference call and webcast will be hosted by InterMune ... Interested investors and others may participate in the ... (international), conference ID#21728775. A replay of the webcast and teleconference ...
(Date:7/28/2014)... , July 28, 2014 Research and Markets ... Size Analysis Market 2014-2018" report to their offering. ... size analysis is a technique used to determine the size ... liquid. It is crucial to analyze the size of particles ... particle size analysis is performed to determine the behavior and ...
(Date:7/26/2014)... Canada Endoscopy Visualization Systems Market ... the Canada Endoscopy Visualization Systems market. The report ... (in units) and average prices (in US dollars) ... Mid-Range Endoscopy Visualization Systems and Low-End Endoscopy Visualization ... . , The report also provides company shares ...
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... today declared a $0.61 per share dividend for the ... on Sept. 5, 2014, to all stockholders of record ... 2014.  About Amgen Amgen is committed ... from serious illnesses by discovering, developing, manufacturing and delivering ...
Breaking Biology Technology:InterMune to Release Second Quarter Financial Results on August 6 2Global Particle Size Analysis Market 2014-2018 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3
... a better husband or wife, daughter or son, sister or ... into a confessional. I've just been thinking about the IT/business ... that relationship work, it's funny how frequently the conversation turns ... family. , ,"Oh great!" you're thinking. "Now you want me ...
... at the Ludwig Institute for Cancer Research , using ... a method to identify thousands of regulatory sequences in the ... , ,The purpose of the study was to find within ... starting points of the genes that determine how cells in ...
... needed to dispose of 1,100 used copier machines, it could ... to the company and a harder-to-calculate cost to the ... the machines by donating them to non-profit organizations. FedEx/Kinkos saved ... ever wondered about what happened to Scott McCallum, Aidmatrix is ...
Cached Biology Technology:Taking your work home 2Taking your work home 3NimbleGen identifies human genome sequences 2Internet charity link has a Wisconsin flavor in CEO Scott McCallum 2Internet charity link has a Wisconsin flavor in CEO Scott McCallum 3
22 x 50 mm; No. 1 thickness range: 0.13 to 0.17 mm, suitable for work in histology, cytology, urinalysis and microbiology, precleaned, store at room temperature ...
... 100%,S-Adenosyl Methionine 2.5%,Adenosine ... <0.1%,Cystathionine ... <0.1%,Glutathione ... Assay Range: 0.1 ug/ml to 1 mg/ml,(0.26 M to 2.6 mM) ...
Panomer 9 oligodeoxynucleotides are random primers that are labeled at the 5' end with our proprietary QSY 7 dye and they are useful for assessing microarray spot morphology, hybridization potential ...
Topoisomerase I, isolated from wheat germ, is an enzyme capable of removing negative supercoils from covalently closed circular DNA (1)....
Biology Products: