Navigation Links
Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

over the course of two years. Baranzini et al. measured the expression level of 70 genes—including a number involved in interferon interactions and immune regulation—at each time point.

The authors used statistical analyses to search for gene expression profiles that were associated with patients' therapeutic outcomes. They looked for patterns in analyses of single genes, gene pairs, and gene triplets, and found their model's predictive accuracy increased with gene number. They also looked for genes that showed different expression patterns over the two years based on patient response, time passed, and patient response over time. These analyses identified genes that increased activity independently of clinical response (interferon can activate genes that have no effect on disease), as well as genes that were associated with a good or poor response. Some of these genes were also the best predictors of patient response before therapy was started.

This approach can predict the probability of a good or poor clinical response with up to 86% accuracy. Baranzini et al. offer hypotheses to explain how the observed gene activity might produce the differential responses to therapy—for example, a poor response may stem from downstream signaling events rather than from problems with drug metabolism. But the authors caution that the mechanisms connecting these genetic signatures to specific outcomes—and the mechanisms that produce a positive interferon response—have yet to be established. For now, these patterns should be thought of as markers. Still, these results suggest that doctors could one day tailor MS patients' treatments to their molecular profile, and perhaps take some of the uncertainty out of this capricious disease.


'"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation
2. Chromosome Deletion Predicts Aggressive Neuroblastoma
3. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
4. Analysis Of Human Genome To Predict The Development Of Illnesses
5. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
6. Predicting success
7. Predicting chemotherapy outcome
8. Predicting successful outcomes in living-donor liver transplants
9. Genes In The Interferon System Important In Systemic Lupus Erythematosus
10. New Vaccine To Be Used For First Time In Polio Outbreak Response
11. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
Post Your Comments:
(Date:9/16/2014)... The risk of severe maternal morbidity amongst women ... suggests a new study published today (17 September) ... and Gynaecology . , Australians generally enjoy high ... that health disparities exist, in particular between indigenous ... aimed to explore the independent impact of socioeconomic ...
(Date:9/16/2014)... YORK (17 September, 2014)More than $100 trillion in ... of annual carbon dioxide (CO2)a 40 percent reduction ... 2050 if the world expands public transportation, walking ... report released by the University of California, Davis, ... (ITDP). , Further, an estimated 1.4 million ...
(Date:9/16/2014)... Pit Fire began on September 13, 2014. The fire ... is currently over 2,300 acres in size and is mostly ... Pit Fire was calm Monday night due to higher humidity. ... anchor point and beginning to construct a fireline on the ... resources are working on the fire: , 7 20-person Crews, ...
Breaking Biology News(10 mins):New study examines the impact of socioeconomic position & maternal morbidity in Australia 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 3Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 2Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 3Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 4Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 5
... Obese women are as much as 28 percent ... pregnancy, according to research that earned a Michigan State ... Barbara Luke, a researcher in the MSU College of ... focused on data of nearly 50,000 women using assisted ...
... the UCLA Henry Samueli School of Engineering and Applied ... the laboratory the enzyme responsible for producing the blockbuster ... published Oct. 23 in the journal Science , ... with similarly beneficial effects. The ...
... at Chicago have received $1 million from the National ... between "fat taxes" and food consumption, diet quality and ... made available through the American Recovery and Reinvestment Act ... rates associated with restaurants and with specific sugar- and ...
Cached Biology News:MSU researcher: Obesity significantly cuts odds of successful pregnancy 2UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin 2UIC receives $1 million grant to study 'fat taxes,' diet, obesity 2
(Date:9/16/2014)... 2014  The Council for Entrepreneurial Development (CED), ... the country, today released a mid-year update to ... It showed that in the first half ... startups in the technology, life science, advanced manufacturing ... a variety of sources. Significant investment in technology companies ...
(Date:9/16/2014)... SANTA BARBARA, Calif. , Sept. 16, 2014 ... Material Strength index (BMSi) test identifies patients with ... tests cannot.  Over 160 million people worldwide are ... be detected by today,s standard bone strength test, ... at the 2014 American Society for Bone and ...
(Date:9/16/2014)... RENU 28, the world's first and only skin ... purchase in Australia and New Zealand in mid-August . , ... The tour will make stops in Brisbane on September 16, ... Sydney on the 20th, and Melbourne on the 22nd. , ... and to educate people about the new product and business ...
(Date:9/15/2014)... 15, 2014  FlexTech Alliance today issued a ... product demonstrators (demos) and a functional electronic print ... pre-proposals due on October 22, 2014 and full ... ultimately selected are provided by the US Army ... share by the proposing organization. Photo ...
Breaking Biology Technology:CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 3CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 4ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 3Global Wellness Company Hosts ASEA Australia Tour September 16-22 2FlexTech Alliance Issues 2015 Request for Proposals in Flexible, Printed Electronics 2
... Jan. 19, 2012  SynCardia Systems, Inc. ( www.syncardia.com ... Heart, announced today that on Dec. 29, 2011, ... Total Artificial Heart patient, 61-year-old Nikola Gaspic, to ... using the Freedom® portable driver . ...
... -- Tianyin Pharmaceutical Co., Inc. (NYSE Amex: ... that specializes in patented biopharmaceutical medicine, modernized ... active pharmaceutical ingredients (API) announced the Company ... certification for its 250-ton Jiangchuan Macrolide Facility ...
...  Synthetic Genomics Inc. (SGI), a privately held company commercializing ... of global challenges, today announced they have hired George ... is a proven leader with experience in developing sophisticated ... and nutritional products for humans and animals. At SGI ...
Cached Biology Technology:Slovenia's 1st Total Artificial Heart Patient Discharged from UMC Ljubljana Using the Freedom® Portable Driver 2Slovenia's 1st Total Artificial Heart Patient Discharged from UMC Ljubljana Using the Freedom® Portable Driver 3TPI Receives GMP Certification for JCM Facility 2TPI Receives GMP Certification for JCM Facility 3Synthetic Genomics Inc. Hires Industry Leader George E. Stagnitti to Head Food and Nutritional Products Development Program 2
... SDSaway reagent is a valuable tool for ... The presence of SDS in biological samples ... bound SDS-protein complex, inhibits enzymatic activity during ... as a contaminant in mass spectrometry analyses. ...
... cGMP Safe Deposit Service ECACC is able ... requirements of cGMP for cryo-storage. The cell lines ... they have been produced in accordance with the ... tested for freedom from mycoplasma, bacteria or fungi. ...
Standard and modified oligonucleotides up to 150 nt-long at any scale for broad applications. Price starts from 30p/base (10 nmole scale)....
... has 20 years of expertise in the ... still offers the most powerful systems on ... to 40 000 in-microplate tests requiring incubation ... of different modules (such as worktable shaker ...
Biology Products: