Navigation Links
Gene Expression in the Aging Brain

No matter how healthy a life one leads, no person has managed to live much longer than a century. Even though the advances of the modern age may have extended the average human life span, it is clear there are genetic limits to longevity. One prominent theory of aging lays the blame on the accumulation of damage done to DNA and proteins by “free radicals,?highly reactive molecules produced by the metabolic activity of mitochondria.

This damage is expected to reduce gene expression by damaging the DNA in which genes are encoded, and so the theory predicts that the most metabolically active tissues should show the greatest age-related reduction in gene expression. In this issue, Michael Eisen and colleagues show that the human brain follows this pattern. A similar pattern—which, surprisingly, involves different genes—is found in the brain of the aging chimpanzee.

The authors compared results from three separate studies of age-related gene expression, each done on the same type of DNA microarray and each comparing brain regions in young versus old adult humans. In four different regions of the cortex (the brain region responsible for higher functions such as thinking), they found a similar pattern of age-related change, characterized by changes in expression of hundreds of genes. In contrast, expression in one non-cortical region, the cerebellum (whose principal functions include movement), was largely unchanged with age. In addition to confirming a prediction of the free-radical theory of aging (namely, that the more metabolically active cortex should have a greater reduction in gene activity), this is the first demonstration that age-related gene expression patterns can differ in different cells of a single organism.

The authors found a similar difference in age-related patterns in the brain of the chimpanzee, with many genes down-regulated in the cortex that remained unchanged in the cerebellum. However, the set of affected cortical genes was
'"/>

Source:PLoS Biology


Page: 1 2

Related biology news :

1. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
2. Iron Deficiency Sparks Dramatic Changes In Gene Expression
3. Applied Biosystems Introduces Advanced Gene Expression Service Provider Program
4. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
5. Research on Worms Yields Clues on Aging
6. Cellular Defects in Premature Aging Disease are Reversible
7. Young Blood Revives Aging Muscles, Stanford Researchers Find
8. Aging cells, aging body: Fresh evidence for a connection
9. Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging
10. Its never too late to get it back! Aging interrupted
11. Transport System Smuggles Medicines Into Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene Expression the Aging Brain

(Date:7/27/2014)... -- Microorganisms like bacteria and fungi can evade treatment ... or antifungal drugs. These permanent mutations were once thought ... evolve. Now a new study has shown that microorganisms ... known as epimutations -- to gain the benefits of ... mechanism was discovered in a fungus called Mucor circinelloides, ...
(Date:7/27/2014)... data from over 18,000 patients, scientists have identified ... in Parkinson,s disease, including six that had not ... Nature Genetics , was partially funded by the ... scientists working in NIH laboratories. , "Unraveling the ... the multiple mechanisms involved in this complex disease, ...
(Date:7/25/2014)... and some of the smoke from those fires is drifting ... the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the Aqua satellite ... over the Great Lakes region of the United States. ... 23, 2014 (first image feature highlighted below) clearly shows the ... In the image, it is over Manitoba and parts ...
Breaking Biology News(10 mins):Scientists discover new, noncommittal mechanism of drug resistance 2Scientists discover new, noncommittal mechanism of drug resistance 3NIH scientists find 6 new genetic risk factors for Parkinson's 2
... relatively new phenomenon in shopping, digital coupons show great ... and usability of a specific type of electronic coupon ... team has found some interesting and important preliminary findings ... used them, why they used them and what problems ...
... of Pennsylvania say that species are still accumulating on ... past. In the study, published in the journal ... computational approach to infer the dynamics of species diversification ... nine patterns of diversification as alternative models, they examined ...
... This release is available in Spanish . ... known as hardening of the arteries, according to results ... with laboratory mice. The research provides the first direct ... lesions, symptomatic of atherosclerosis, from increasing in size in ...
Cached Biology News:Impending death for paper coupons? 2Impending death for paper coupons? 3Penn biologists say species accumulate on Earth at slower rates than in the past 2Blueberries help fight artery hardening, lab animal study indicates 2
(Date:7/25/2014)... -- Trillions of bacteria live in each person,s digestive ... digest food and stave off harmful infections, but their ... To help shed light on the role of these ... professor Eric Alm recently tracked fluctuations in the bacterial ... The findings, described in the July 25 issue of ...
(Date:7/25/2014)... July 25, 2014 The Conferee Networking ... Topics for Conferee Networking. These two-hour sessions provide a ... meet and resolve problems, discuss new techniques, or brainstorm ... to submit a topic for consideration is August 31, ... . The Conferee Networking committee will review the topics, ...
(Date:7/25/2014)... Sinovac Biotech Ltd. (Nasdaq: SVA ), ... , today announced that it will release its unaudited ... after market close on Thursday, August 14, 2014 EDT. The ... opening on Friday, August 15, 2014, at 8:00 a.m. EDT ... to review the Company,s financial results and provide an update ...
(Date:7/24/2014)... 2014  Asterias Biotherapeutics, Inc. (OTCBB: ASTYV), a ... regenerative medicine, announced today that it will host ... on Tuesday, July 29, 2014, at 4:30 p.m. ... an overview of Asterias, business strategy and product ... http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 minutes before the ...
Breaking Biology Technology:Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4
...  Amgen (NASDAQ: AMGN ) today announced that it ... results on Thursday, Jan. 26, 2012 after the close of ... conference call with the investment community at 2:00 p.m. Pacific ... Kevin Sharer, chairman and chief executive officer, and other members ...
... SPO Medical Inc. ( SPOM ), a ... in portable monitoring devices, announced today an update to ... strategy for fiscal 2012 primarily based on the completion ... consumer wellness devices. SPO currently has three ...
... team have shown that they can prevent, or even reverse, ... dogs. The disease in humans and dogs is caused ... severe and progressive vision loss. It is one of the ... "Every single abnormal feature that defines the disease in ...
Cached Biology Technology:Amgen Announces Webcast of 2011 Fourth Quarter and Full Year Financial Results 2SPO Updates Shareholders on 2012 Corporate Strategy 2SPO Updates Shareholders on 2012 Corporate Strategy 3Gene therapy research from Penn Vet & Scheie Eye Inst. cures retinitis pigmentosa in dogs 2Gene therapy research from Penn Vet & Scheie Eye Inst. cures retinitis pigmentosa in dogs 3
... N. Fernandez and G. Butcher (1998). ... subject of much research in the immunology ... structure of MHC proteins and in their ... are now faced with the prospect of ...
DALT GRADIENT MAKER,230V, 1 EA. Category: 2D DALT Systems....
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
Rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and refrigerated within 6 hours, and processed and frozen within 24 hours. The serum is ...
Biology Products: