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Gatekeeping: Penn researchers find new way to open ion channels in cell membranes

sult. For example, mutations in some channel genes cause cardiac arrhythmias, including a form of the lethal long QT syndrome.

Voltage-gated ion channels are also present in the so-called non-excitable cells (such as immune, blood, and bone cells) whose membrane voltage stays largely constant, as opposed to the excitable cells whose membrane voltage constantly varies in a precisely controlled manner. How the activity of channels in non-excitable cells is regulated has been a long-standing biological mystery. This new finding that SMase D can open ion channels without changing membrane voltage provides a clue to the mystery.


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Source:University of Pennsylvania School of Medicine


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