Navigation Links
Gardenia fruit compound starting point for diabetes therapy

"When I first saw the results, I was in disbelief," Lowell said. "I didn't think we could ever be that lucky." However, blinded repetition of the initial experiments confirmed the results every time, he said.

Through a series of chemical analyses, the researchers then zeroed in on genipin as the active compound. Genipin, like the extract, stimulated insulin secretion in control but not UCP2-deficient pancreas cells.

They further found that acute addition of genipin to isolated pancreatic tissue reversed high glucose- and obesity-induced dysfunction of insulin-producing beta cells. A derivative of genipin that lacked the chemical's cross-linking activity continued to inhibit UCP2, they reported.

That's a good sign for the therapeutic potential of genipin-related compounds, according to Lowell, as such indiscriminate cross-linking would likely have adverse effects. However, further work will need to examine whether inhibition of UCP2 itself might also have some negative consequences.

In addition to the possibility of new drugs, the findings might also prove a boon to the use of Gardenia extract itself for the treatment of disease, particularly in eastern Asia, Zhang said.

Irrespective of genipin's potential for clinical applications, its benefits within the scientific community are already clear, Lowell added.

"Genipin represents an extremely useful investigational tool for studying a number of aspects of UCP2 biology," Lowell added. UCP2 plays a role in the process by which food is converted into energy storage molecules by cellular powerhouses called mitochondria in cells throughout the body.


'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Master gene controls healing of skin in fruit flies and mammals
2. UI researcher studies deafness in fruit flies, humans
3. Gap-climbing fruit flies reveal components of goal-driven behaviors
4. Hormones and growth: The control of body size and developmental growth rate in fruit flies
5. Aloe vera coating may prolong freshness, safety of fruits and vegetables
6. Hanging baskets of sex and death help fruit growers
7. Researchers find gland that tells fruit flies when to stop growing
8. Past experience of pheromones induces dominant courtship behavior in fruit flies
9. A resetting signal keeps circadian rhythm on track in Drosophila fruit flies
10. Drunken elephants: The marula fruit myth
11. UCSD study finds anthrax toxins also harmful to fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gardenia fruit compound starting point for diabetes therapy

(Date:7/11/2014)... from Ume University, Sweden, have explored two different ... reaction sequence leading to the formation of oxygen ... published in the scientific journal Nature Communications ... present day synthetic catalysts for water oxidation, which ... for the direct storage of solar energy in ...
(Date:7/11/2014)... that transplantation of mesenchymal stem cells can stimulate neurogenesis ... of Alzheimer,s disease (AD) and improve tissue and function ... are reported on the therapeutic effect of adipose-derived stem ... the effect on oxidative injury and neurogenesis in the ... team, School of Life Sciences, Tsinghua University, China transplanted ...
(Date:7/11/2014)... Evidence exists that cannabinoid receptor type 1 ... Ca2+ influx, and reduce neurotransmitter release. However, ... 1 can increase extracellular Ca2+ influx and ... his team, Tongji Hospital Affiliated to Tongji ... Technology, China used whole cell voltage-clamp and ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... electronic skin, or e-skin, and electronic eye implants or ... Researchers with Berkeley Lab and the University of California ... of carbon nanotubes and silver nanoparticles similar to the ... e-whiskers respond to pressure as slight as a single ...
... of men,s bones - but only if they marry when they,re ... In a study published online in the peer-reviewed journal Osteoporosis ... were younger than 25 had lower bone strength than men who ... In addition, men in stable marriages or ...
... climate. Take, for example, the Mayans, who, throughout the ... their major ceremonial centers after a series of multi-year droughts, ... forests. Much later, in the late 20th century, frequent droughts ... migrate from the dry north to the wetter south where ...
Cached Biology News:E-whiskers 2Guys: Get married for the sake of your bones, but wait until you're 25 2Guys: Get married for the sake of your bones, but wait until you're 25 3Princeton model anticipates ecological impacts of human responses to climate 2Princeton model anticipates ecological impacts of human responses to climate 3
(Date:7/14/2014)... 14, 2014 Throughout this past ... the clinical trials space, representing 38 countries globally, ... entitled “Optimizing Patient Participation in Clinical Trials. Attract. ... with internationally renowned R&D expert, Ken Getz, of ... Reinventing Drug Development through Patient Centricity. , Throughout ...
(Date:7/13/2014)... 2014 Deep Research Report on Global and ... study on the current state of the Nano Silver ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:7/11/2014)... , July 11, 2014 Research ... "International Transfection Technology Market - Global Industry Analysis, Size, ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... introduce nucleic acids (either DNA or RNA) into cells. ... mutation of cancer cells and protein metabolism by affecting ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
Breaking Biology Technology:Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 52014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... , for routine high fidelity amplification of up to 3.5 kb , ... 100 units , Cat. No. 1 664 955 ... , , Description , , , ... archaebacterium Pyrococcus woesei. The enzyme has a molecular weight of , ...
... , for routine amplification of up to 3 kb genomic DNA ... , , , , , ... contains 10 vials of 2x concentrated PCR reaction , mix (Taq ... dNTPs) plus water PCR grade (for dilution), sufficient for 100 , ...
... for amplification of up to 5 kb targets from genomic DNA ... , , , , , ... concentrated High Fidelity PCR Master contains all necessary , reagents ... a unique enzyme blend of Taq DNA Polymerase and Pwo DNA Polymerase[a thermostable , ...
Cached Biology Technology:Pwo DNA Polymerase 2Pwo DNA Polymerase 3PCR Master 2PCR Master 3High Fidelity PCR Master 2