Navigation Links
'Gadonanotubes' greatly outperform existing MRI contrast agents

Researchers at Rice University, the Baylor College of Medicine, the University of Houston and the Ecole Polytechnique Fédérale de Lausanne in Switzerland have created a new class of magnetic resonance imaging (MRI) contrast agents that are at least 40 times more effective than the best in clinical use.

The new agents -- dubbed gadonanotubes -- use the same highly toxic metal, gadolinium, that is given to more than a quarter of MRI patients today, but the metal atoms are encased inside a hollow tube of pure carbon called a nanotube. Shrouding the toxic metals inside the benign carbon is expected to significantly reduce or eliminate the metal's toxicity.

The research was published this month in the journal Chemical Communications.

"In prior work, we have boosted the effectiveness of gadolinium MRI contrast agents by encasing them in spheres of carbon called buckyballs," said lead author Lon Wilson, professor of chemistry at Rice. "Each nanotube will hold more gadolinium atoms than a buckyball, so we expected them to be more effective agents. But they are actually much, much better than we anticipated, so much so that no existing theory can explain how they work."

Wilson and colleagues use short segments of nanotubes, tiny cylinders of pure carbon about one billionth of a meter, or one nanometer, in diameter. That's about as wide as a strand of DNA. The ultrashort segments are only about 20-100 times longer than they are wide, and once inside the nanotubes, the gadolinium atoms naturally aggregate into tiny clusters of about 10 atoms each. Wilson and colleagues suspect the clustering is causing the unexplained increases in magnetic and MRI effects that they observed in tests at Rice, at the University of Houston's Texas Center for Superconductivity, and in the Swiss laboratories.

More than 25 million patients in the U.S. undergo MRIs each year. Doctors use contrast agents in about 30 percent of MRIs. The contrast agents increase t
'"/>

Source:Rice University


Page: 1 2

Related biology news :

1. Low oxygen likely made Great Dying worse, greatly delayed recovery
2. Survival of heart patients on beta-blockers varies greatly with genetic variation
3. Access to existing medical treatments could save more lives than spending to improve the treatments
4. Got inexpensive contrast agent? Milk plays new role in imaging
5. Tiny avalanche photodiodes target bioterrorism agents
Post Your Comments:
(Date:8/21/2014)... by an international standards process, will be available soon ... invited review published in the OnlineFirst version of ... official journal of the American Society for Parenteral and ... the occurrence of misconnection that can be harmful and ... used to join medical devices, components, and accessories to ...
(Date:8/21/2014)... replicated one of the crucial steps in photosynthesis, opening ... could manufacture hydrogen as a fuel. , "Water is ... prospect to use them to create hydrogen, and do ... the ARC Centre of Excellence for Translational Photosynthesis in ... potential as a zero-carbon replacement for petroleum products, and ...
(Date:8/21/2014)... the pancreas digesting itself resulting in severe abdominal pain, ... around 20,000 patients are diagnosed with the disease resulting ... treatment is restricted to intravenous fluid and nutritional support. ... Life Sciences, who led the research, said "The major ... stones and excessive alcohol intake combined with a high ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Water and sunlight the formula for sustainable fuel 2Insulin offers new hope for the treatment of acute pancreatitis 2
... in Spanish . , Those who enjoy ... teas may tend to overlook the benefits of drinking herbal ... Research magazine, the idea that herbal teas may provide a ... U.S. Department of Agriculture (USDA)-funded scientists in Boston, Mass., have ...
... March 1, 2011 When patients receive a bone marrow ... cells. Fresh stem cells are needed when a patient is ... blood cells, which can be caused by cancer or even ... that a bone marrow transplant might not succeed because the ...
... has the potential to revolutionise the way autopsies are ... pathologists and radiologists at the University of Leicester in ... The technique developed by a team in the ... Leicester, has been published today (1 March) in ...
Cached Biology News:Don't underestimate the power of herbal teas 2How long do stem cells live? 2New non-surgical autopsy technique set to revolutionize post-mortem practice 2
(Date:8/21/2014)... N.Y. , Aug. 21, 2014 ... launch of their Nutraceutical "TELO-20 for Dogs" with ... only Telomere-lengthening supplement in the world for dogs. ... of every chromosome in the body. A wealth ... leading experts in Telomere Science and Aging, including ...
(Date:8/21/2014)... Mathematic studies at the Program for Evolutionary ... by the Jeffrey Epstein VI Foundation , have shown ... identified for elimination. These aggressive cells are the driver mutations ... topological map of what to look for when examining tumors, ... tumor cells can be extracted from biopsy, it,s very difficult ...
(Date:8/21/2014)... , Aug. 21, 2014  Four-dimensional (4-D) ... behaviors based on external stimuli such as changes ... have a disruptive effect in multiple industries.  In ... business landscape by printing objects ranging from human ... automotive sectors. Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... MO (PRWEB) August 21, 2014 ... service biopharmaceutical contract development and manufacturing organization (CMO) ... Progenics Pharmaceuticals, Inc., an oncology company focused on ... treating cancer, to manufacture the anti-prostate specific membrane ... ADC product candidate. Under the agreement the ...
Breaking Biology Technology:Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3
... to Early Cardiovascular,Events in Asian Populations, WALTHAM, ... ILI ), announced today that Kenneth Kornman, Ph.D., ... findings on,the genetics of cardiovascular disease at the ... place from Oct. 31 -,Nov. 1, 2008, at ...
... Fingerprint portraits go global by incorporating cutting-edge localization technology online to target ... ... New York, NY (PRWEB) October 30, 2008 -- DNA 11, the original ... mark global growth with the launch of a new website that will ...
... databases enable ,researchers to quickly and effectively use these invaluable resources. ... ... announced the availability of newly updated tutorial suites on the DataBase of ... is a public resource for the analysis of promoter regions. , ...
Cached Biology Technology:Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 2Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 3Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 4DNA 11, Creators of DNA Art Goes Global 2Updated Online Tutorials for DBTSS, Pfam and PDB 2Updated Online Tutorials for DBTSS, Pfam and PDB 3
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
... is a direct antibiotic-based selection system for ... colony survival, eliminating the need for costly ... provides close to 100% accuracy in recombinant ... for robot colony picking. This cloning kit ...
... software for the microscopy market by ... components and peripherals with powerful archiving, ... intuitive interface simplifies workflow and speeds ... powerful features such as image stitching, ...
Mouse monoclonal [IA-C6] to MHC Class II I Ab + Ad (FITC) ( Abpromise for all tested applications). Antigen: Tissue / cell preparation of Purified Mouse lymph node B cells...
Biology Products: