Navigation Links
Future diabetes drugs may target new protein interaction

like its sirtuin relatives, is best known for removing molecular "decorations" on proteins that help organize DNA and restrict access to genes. It turns out that sirtuin1 also removes these decorations from PGC1, and then remains bound to PGC1 as it starts up the sugar-making process, the researchers found.

"Because both proteins are required for the liver to make sugar, targeting sirtuin1 in a very specific way might help control sugar production in people with diabetes," says Puigserver. "Sirtuin1 interacts with many different proteins, and it's just this one interaction you would want to prevent."

But, he says, PGC1 has an unusually close relationship with sirtuin1 that may make for relatively easy picking. PGC1, unlike the vast majority of proteins, only uses sirtuin1 to remove its "decorations," called acetyl groups. Most other proteins can have the groups plucked off by a number of different enzymes.

"PGC1 is a 'clean' target for sirtuin1," says Puigserver. "If sirtuin1 isn't available, PGC1 becomes covered in acetyl groups, and the acetyl-covered PGC1 can't make sugar."

In their experiments, graduate student Joseph Rodgers also discovered that the livers of fasted mice first developed high levels of a chemical called pyruvate, which is a starting material for making glucose, and then accumulated high levels of sirtuin1 protein. (Rodgers will receive the Nupur Dinesh Thekdi Research Award on April 14 for this work as part of the School of Medicine's 28th annual Young Investigators' Day celebration.)

"When there's no incoming food, muscles make lactate and alanine and send them to the liver to be converted into pyruvate and glucose," says Puigserver. "It appears, from our work, as though the pyruvate then triggers increased production of sirtuin1, which in turn lets PGC1 start converting the pyruvate into the glucose the body needs to survive."

The relationship between sirtuin1 and PGC1 also connects processes in
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Chemists identify key gene in development of type 1 diabetes
2. Rare surgery performed to remove pancreas, prevent diabetes
3. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
4. New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
5. UCSD study clarifies insulins role in blocking release of energy in patients with type II diabetes
6. Researchers reverse juvenile diabetes in animal model
7. Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice
8. Traditional Chinese medicine for diabetes has scientific backing
9. One-third of adults with diabetes still dont know they have it
10. The molecular mechanism of a diabetes vaccine revealed
11. Compound in dairy products targets diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Future diabetes drugs may target new protein interaction

(Date:5/16/2013)... Access to Research Careers) Program has announced the ... 95th Annual Meeting in San Francisco, CA from ... promote the entry of students, postdoctorates and scientists ... basic science community and to encourage the participation ... Meeting. , Awards are given to poster/platform presenters ...
(Date:5/16/2013)... scientists have used ancient shorelines to predict the stability of ... a high shoreline from three million years ago, for example ... were thought to be evidence of a high sea level ... has led many scientists to think that if the world,s ... do just the same in our modern, progressively warming world. ...
(Date:5/16/2013)... cellular layer lining the body,s blood vessels, is ... in thickness, this super-tenuous structure routinely withstands blood ... create a unique and highly dynamic barrier that ... the body,s circulatory system. , It,s also extremely ... physically breached to enable immune cells to ...
Breaking Biology News(10 mins):World's biggest ice sheets likely more stable than previously believed 2Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4
... the Marine Biological,Laboratory (MBL) has published the ... supports her hypothesis that, when combined, the ... BCE--can act synergistically to alter a key ... previously studied the effects,of these pollutants individually, ...
... of fluorescence detection developed by researchers at Baylor College ... doors that would take DNA sequencing to the patient's ... a crime or a battlefield. , "We could eventually ... DNA" without manipulation now performed in the laboratory, said ...
... The crystallized form of a molecular machine that can ... paths for treating diseases such as some forms of ... Purdue University researchers froze one of these molecular machines, ... intron, at mid-point in its work cycle. When frozen, ...
Cached Biology News:Study identifies predictors of HIV drug resistance in patients beginning triple therapy 2Study identifies predictors of HIV drug resistance in patients beginning triple therapy 3Color-blind method opens new doors in DNA sequencing 2Color-blind method opens new doors in DNA sequencing 3Molecular machine may lead to new drugs to combat human diseases 2Molecular machine may lead to new drugs to combat human diseases 3
(Date:5/17/2013)... 17, 2013 Rust removal is one of ... home items could be damaged. To help rust contractors make ... its no-scrubbing rust remover it called Rusterizer. It ... with 10% discount. , My Cleaning Products explained that rust ... or by staining them. The first one, it said, ...
(Date:5/16/2013)... 2013 ISPE announced ... CAE, to the newly created position of Vice ... Myers will be responsible for stimulating ISPE’s revenue ... advancing the Society’s Member-led and staff-driven business model, ... refine organizational, membership and product marketing. , “Barbara ...
(Date:5/16/2013)... 16, 2013 Cambridge Healthtech Institute will ... 19-23, 2013 at the Renaissance Waterfront Hotel in Boston, ... a close-up look at the current strategies and innovations ... quality. Leaders in the field will reveal how ... biopharmaceuticals with greater specificity and efficiency. , “In this ...
(Date:5/16/2013)... Calif. , May 16, 2013 Scientists ... Beijing , and the ... ) have demonstrated a novel therapy for reversing memory ... magnesium levels, they find significant cognitive improvement in advanced ... demonstrate a mechanism for reversing cognitive decline for advanced ...
Breaking Biology Technology:Organic-Based Rust Remover Cuts Down Price by 10%, My Cleaning Products Details Mechanics How to Get the Discount 2ISPE Names Barbara A. Myers, CAE, as Vice President of Professional Development 2The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3
... Oct. 31 Novo Nordisk (NYSE:,NVO), a global healthcare company, today ... 30, 2007. -- Novo Nordisk increased sales by 14% in ... kroner due to a significant negative currency development. ... Danish kroner). -- Sales of NovoSeven(R) increased ...
... Kinetics Study ... Data, ... OTC: MGIFF), a clinical-stage developer of drugs for infectious,diseases will present at ... the New York Palace Hotel in New York,NY on November 5-7, 2007. ...
... (Nasdaq: IDIX ) announced today that it will ... on Tuesday, November 6,2007 after the U.S. financial markets ... press release, Idenix,management will host a conference call at ... the company,s financial results for the third quarter,2007. ...
Cached Biology Technology:Novo Nordisk Increased Operating Profit by 11% in the First Nine Months of 2007 Based on a 9% Sales Increase and an Improved Gross Margin 2MIGENIX to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 2MIGENIX to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 3
Monoclonal Anti-Cystatin A tissue culture supernatant Solution containing 15 mM sodium azide human cystatin A ...
... SSCP kit provides all the accessories necessary ... single-stranded conformation polymorphism analysis (SSCP) with the ... includes a cooling finger adaptor for use ... sets of 20 cm plates, 2 sets ...
... analysis kit for 25 chips provides the ... RNA analysis (at nanogram levels) with the ... 25 RNA StdSens microfluidic chips, 2 x ... microliters RNA StdSens stain, 2 x 20 ...
... has made microcapillary flow cytometry accessible to ... alike will appreciate the latest addition to ... to use, surprising affordable, and very compact ... includes such features as absolute cell counts, ...
Biology Products: