Navigation Links
Fruit fly's beating heart helps identify human heart disease genes

e potential to greatly speed the process of finding and verifying candidate human genes for heart disease," Wolf continued. "In our experiments, we were able to demonstrate for the first time that a mutated gene that causes a specific heart disease in a human causes the same disease in the fruit fly."

Senior author on the paper was cardiologist Howard Rockman, M.D. Other co-authors were fruit fly geneticist Hubert Amrein, Ph.D. in Duke Medical Center, and bioengineers Joseph Izatt, Ph.D. and Michael Choma, Ph.D. of Duke's Pratt School of Engineering. The research was supported by the National Institutes of Health.

In recognition of his research, the American Heart Association bestowed upon Wolf its prestigious Louis N. and Arnold M. Katz Basic Research Prize in November during its annual scientific sessions. This is the second year in a row that a trainee in Rockman's lab has won the Katz prize. Last year, Naga Prasad, Ph.D. received the award.

In the past, researchers could not accurately study heart disease in fruit flies because of an inability to accurately image heart function of a living adult fly. Past investigators have measured the size of the heart and then made assumptions about what was happening inside, or dissected flies after death.

For their experiments, the Duke team adapted a technology known as optical coherence tomography (OCT), which is commonly used to measure the thickness of the retina in the eye, to obtain detailed images of the beating heart of an adult, unanesthetized fly.

"After inserting into the fly the gene that we know is implicated in dilated cardiomyopathy in humans, we imaged the adult fly with this novel system and what we saw looked exactly like the same condition in humans," Wolf said. "We obtained clear images that looked similar to an echocardiography study of a human patient with heart failure."

According to Rockman, about 80 percent of the gene mutations known to cause disease
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
2. Fruit fly studies open new window on cancer research
3. Fruit fly research set to revolutionize study of birth defects
4. How Fruitflies Know Its Time for Lunch
5. Fruit fly reveals a potential connection between dementia and cancer
6. Fruit fly dating game provides clues to our reproductive prowess
7. Fruit fly aggression studies have relevance to humans, animals
8. Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine
9. Fruit fly study identifies gene mutation that regulates sensitivity to alcohol
10. Fruit flies and global warming -- Some like it hot
11. Fruit fly gene research may shed light on human disease processes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Fruit fly beating heart helps identify human heart disease genes

(Date:8/20/2015)... Aug. 20, 2015   Sensory, Inc ., ... the user experience and security of consumer electronics ... announced that its TrulySecure™ is the ... to be FIDO Certified™. The FIDO ... with the FIDO UAF (Universal Authentication Framework) 1.0 ...
(Date:8/18/2015)... , Aug. 18, 2015  Navitas today ... contributor to the Submission Content Management webinar ... a non-profit forum. Dedicated to the Implementation of ... neutral platform for industry, vendors, health authorities, ... and work towards a standard method of ...
(Date:8/12/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is proud to announce that iMedNet ... platform, has led the way to significant and unprecedented ...   Q2 2015 and Q1 2015 were, respectively, the ... sold in the company,s 15 year history.  In addition, ...
Breaking Biology News(10 mins):TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3MedNet Solutions Experiences Explosive Corporate Growth 2
... genetic signature associated with Alzheimer,s disease, the leading ... elderly. The research, published by Cell Press in ... of Human Genetics , uses a powerful, high-resolution ... devastating neurodegenerative disorder. Previous research linked ...
... examining patterns of DNA modification in lung cancer, a team ... surprising new mechanism. They say that "silencing" of a single ... genome-wide changes in cells, contributing to cancer development and progression. ... Research , a journal of the American Association for Cancer ...
... beta carotene or vitamin C or E or a combination ... women who did not take the supplements, according to data ... issue of the Journal of the National Cancer Institute. ... are high in fruits and vegetables, and thus antioxidants, may ...
Cached Biology News:Scientists make strides toward defining genetic signature of Alzheimer's disease 2In lung cancer, silencing one crucial gene disrupts normal functioning of genome 2In lung cancer, silencing one crucial gene disrupts normal functioning of genome 3Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial 2
(Date:9/3/2015)... , Sept. 3, 2015 /PRNewswire/ - bioLytical Laboratories ... to announce its study " Sensitivity of a rapid ... is enhanced by its affinity for HIV gp41 IgM ... Clinical Virology.  This study highlights INSTI,s ability to detect ... their findings at the 8 th annual International ...
(Date:9/3/2015)... MA (PRWEB) , ... September 03, 2015 , ... If ... conference in Boston this October, you will also want to sign up for ... Sunday, October 18th. The tour includes a walk through of the (8) chemistry ...
(Date:9/2/2015)... -- Research and Markets ( ... PharmaBiotech,s new report "Biochips and Microarrays - ... This report is an analysis of ... report starts with a description of technologies as ... array comparative genomic hybridization (CGH), copy number variation ...
(Date:9/2/2015)... Biovista Inc. is glad to ... BeHEARD science challenge, a global competition hosted by the ... to the latest life science innovations and technologies. ... analytics capability to support Steven Laffoon and ... of Niemann-Pick Disease Type A (NPA), a rare and ...
Breaking Biology Technology:bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 2bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 3Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2
... CAMBRIDGE, Mass. -- By activating multiple fluorescent proteins in neurons, ... system as never before, rendering their cells in a riotous ... described in the cover story of the Nov. 1 issue ... Jean Livet, Joshua R. Sanes, and Jeff W. Lichtman. , ...
... State Universitys National High Magnetic Field Laboratory have successfully tested ... light on nanoscience and semiconductor research. , When the magnet ... 2010, researchers will have the ability to direct and scatter ... or center, of the magnet, but also from four ports ...
... Vermillion, Inc.,(Nasdaq: VRML ) announced today that it ... Healthcare Conference in New York. Gail Page,President & CEO, ... on,Tuesday, November 6, 2007. A webcast of the ... both the live and archived webcast, please go to, ...
Cached Biology Technology:Scientists create colorful 'brainbow' images of the nervous system 2Let there be light: new magnet design continues magnet lab's tradition of innovation 2
Anti Human S14G-Humanin Polyclonal Antibody...
... Useful as a positive control for ChIP ... chromatin in vivo is a crucial step ... of crosslinking is probably the most important ... immunoprecipitation step should be taken into account: ...
Mouse monoclonal antibody to ANAPC2 - anaphase promoting complex subunit 2...
Handy 100V Power Supply is Low-cost, compact and lightweight. Easy to operate - either 50 or 100 VDC is selectable as the output voltage. These voltages are sufficient for ordinary electrophoresis....
Biology Products: