Navigation Links
Fruit fly studies open new window on cancer research

Scientists studying the humble fruit fly have found a family of proteins that enhances the sensitivity of a cell to a hormone that can trigger abnormal growth and cancer. Their discovery could lead to a completely new approach to tackling some cancers and the development of new drugs to stop uncontrolled growth in a wide variety of tumour cells.

The researchers at the University of Oxford, funded in part by the Biotechnology and Biological Sciences Research Council (BBSRC), discovered that this family of amino acid transporters are very powerful growth promoters. When the transporters were overexpressed in a fly, its cells became hypersensitive to insulin-like molecules in the body that have a long-term role in promoting cell growth and development and the cells grew excessively.

The amino acid transporters appear to be responsive to nutrients on the surface of the cell and do not need to bring these nutrients into the cell. The action of the transporters was so significant that a defect in one of them reduces a fly's growth by about half.

Dr Deborah Goberdhan, one of the researchers involved, said, "We are now looking at whether human equivalents of these fruit fly genes act in the same way. If they do, then new drugs or even dietary advice could block their activity and slow down the growth of tumours. This research tells us more about the way insulin works and so it is furthering our understanding of processes associated with diabetes as well as cancer. We're fortunate that there are a number of groups with clinical interests in these areas in close proximity to us, which should help us assess the medical significance of our discovery."

Fruit flies are used in research because a large amount of data about them has been gathered over the last hundred years. As a simple animal with a life cycle of only two weeks, mutations are easy to generate and study. This basic research at Oxford has now attracted funding from Cancer Research UK to further investigate the processes involved and allow Dr Goberdhan to establish her own group.

Professor Julia Goodfellow, BBSRC Chief Executive, remarked, "Although research into fruit flies may not seem an immediate priority, only fundamental research such as this can provide us with the understanding that leads to new applications. New treatments for illnesses such as cancer will only be found as we increase our knowledge of basic biological processes."


'"/>

Source:Biotechnology and Biological Sciences Research Council


Related biology news :

1. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
2. Fruit fly research set to revolutionize study of birth defects
3. How Fruitflies Know Its Time for Lunch
4. Fruit flys beating heart helps identify human heart disease genes
5. Fruit fly reveals a potential connection between dementia and cancer
6. Fruit fly dating game provides clues to our reproductive prowess
7. Fruit fly aggression studies have relevance to humans, animals
8. Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine
9. Fruit fly study identifies gene mutation that regulates sensitivity to alcohol
10. Fruit flies and global warming -- Some like it hot
11. Fruit fly gene research may shed light on human disease processes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... Germany , December 15, 2016 ... today announced an agreement with NuData Security, an award-winning ... The partnership will enable clients to focus on good customer ... data protection regulation. ... In order to provide a one-stop fraud prevention ...
(Date:12/15/2016)... , Dec. 15, 2016  There is much more ... or starting the engine. Continental will demonstrate the intelligence ... Las Vegas . Through the combination of the ... Entry) and biometric elements, the international technology company is ... personalization and authentication. "The integration of biometric ...
(Date:12/8/2016)... 2016  Singulex, Inc., the leader in Next Generation ... a license and supply agreement with Thermo Fisher Scientific, ... Singulex access to Thermo Scientific BRAHMS PCT (Procalcitonin), a ... used to diagnose systemic bacterial infection and sepsis and ... aid in assessing the risk of critically ill patients ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... , Jan. 18, 2017  Northwest Biotherapeutics, Inc. ... DCVax® personalized immune therapies for operable and inoperable solid ... , Chief Technical Officer of NW Bio, will present ... 19, 2017, at the Hyatt Regency Hotel in ... will chair the session entitled "New Therapeutic Approaches – ...
(Date:1/18/2017)... Mass. , Jan. 18, 2017   Boston ... novel compounds designed to target cancer stemness pathways, will ... investigational compound, napabucasin, at the 2017 ASCO Gastrointestinal Cancers ... Francisco . Napabucasin is an ... by targeting STAT3. i Cancer stem cells (CSCs) ...
(Date:1/18/2017)... ... 2017 , ... Whitehouse Labs has furthered its efforts towards ... (AMRI), the scientific staff dedicated to Extractables / Leachables & Impurities has more ... 2017. Extractable & Leachable evaluations have become increasingly more vital to successful product ...
(Date:1/18/2017)... ... 2017 , ... BidMed, LLC, announced it will hold a 1-day ... equipment from two different leading institutes. This highly specialized laboratory equipment is coming directly ... This 1-day online auction will take place on BidMed’s website http://www.bidmed.com ...
Breaking Biology Technology: