Navigation Links
Fruit fly reveals a potential connection between dementia and cancer

By expressing a protein associated with Alzheimer's disease in the brain of the fruit fly, researchers have demonstrated an intriguing link between neuronal death and proteins previously associated with cancer.

The findings are reported by Vik Khurana, Mel Feany, and colleagues from Brigham and Women's Hospital, Harvard Medical School, and the Burnham Institute.

Neurons in the brain generally do not divide. It is therefore perplexing that in Alzheimer's disease, and other dementias associated with a protein called tau, dying neurons actually re-express proteins normally seen during cell division or in cancer. It has previously been unclear whether such cell-division proteins cause neuronal death, protect neurons from death, or are irrelevant.

In the present work, the researchers used a fruit-fly model of Alzheimer's disease to examine the relationship of cell-division proteins to neurodegeneration. The power of this model, which recapitulates key features of the human disease, lies in the ability to use genetic tools to establish a causal connection between a molecular pathway and neuronal death. Khurana and colleagues found that, as in human disease, abnormal expression of cell-cycle proteins accompanied neuronal death in their fly model. Most importantly, loss of neurons could be prevented when the cell cycle was genetically blocked or when flies were fed anticancer drugs. Cell-cycle activation depended upon a hyperactive cell growth molecule, TOR (target of rapamycin), also known to be abnormally activated in Alzheimer's disease. By establishing these causal connections, this study suggests that anticancer drugs are potential therapies for Alzheimer's disease and related disorders. More broadly, the results point to an intriguing connection between cancer and dementia, two of the most important diseases in the elderly.


'"/>

Source:Cell Press


Page: 1

Related biology news :

1. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
2. Fruit fly studies open new window on cancer research
3. Fruit fly research set to revolutionize study of birth defects
4. How Fruitflies Know Its Time for Lunch
5. Fruit flys beating heart helps identify human heart disease genes
6. Fruit fly dating game provides clues to our reproductive prowess
7. Fruit fly aggression studies have relevance to humans, animals
8. Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine
9. Fruit fly study identifies gene mutation that regulates sensitivity to alcohol
10. Fruit flies and global warming -- Some like it hot
11. Fruit fly gene research may shed light on human disease processes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 25, 2017 , ... LABS, Inc. (LABS) announced ... added to its extensive test menu: Nucleic Acid Testing (NAT) for ZIKV; and Enzyme ... only able to offer NAT screening for blood donors under an Investigational New Drug ...
(Date:4/26/2017)... ... April 26, 2017 , ... NextSteps ... and North America this May on the following dates: , ?    London, ... Taylor, Chairman of the Learning and Performance Institute will be the opening ...
(Date:4/26/2017)... April 26, 2017  Genisphere LLC, provider of ... signed a collaborative and sponsored research agreement with ... Muro . The overall goal of the partnership ... various 3DNA designs and formulations after in ... of the vasculature as well as inflammatory responses, ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... of Common Lisp (CL) development tools, and market leader for Semantic Graph ... performance enhancements now available within the most effective system for developing and deploying ...
Breaking Biology Technology: