Navigation Links
Fruit fly research set to revolutionize study of birth defects

A Queen's University study of fruit flies that may revolutionize the way birth defects are studied has identified the genes affected by a widely-prescribed drug known to cause birth defects.

Methotrexate (MTX), a popular cancer-fighting drug also used to treat psoriasis, ectopic pregnancies, rheumatoid arthritis, and lupus, lasts a long time in the body and causes birth defects in children from women who have it in their systems. The study of the drug's effect on fruit flies has allowed Queen's researchers including graduate student Joslynn Affleck to identify the genes on which the drug acts.

"We hope that through this model system we can provide insight into mammalian birth defects, which may be expected to increase in frequency in the future, due to the recent elevated use of MTX," says Affleck.

Many of the genes found to be affected by MTX are involved in cell cycle regulation, signal transduction, transport, defense response, transcription, or various aspects of metabolism.

"This study shows that MTX treatment has multiple targets," says Affleck. "And this provides us with a novel invertebrate model for the study of drugs that cause birth defects." The findings, funded by NSERC, are set to be published by Toxicological Sciences in the New Year.

"This is not a journal in the habit of publishing insect studies," notes biologist Dr. Virginia Walker, who co-authored the study. "The neat thing about this work is that fruit flies treated with this drug show 'birth defects' that are hauntingly similar to birth defects in human babies. Babies have bent limbs, tufts of hair and bulging eyes and the fruit flies have bent legs (and wings), tufts of bristles and rough eyes."

While identifying this gene array is significant in its own right, the successful use of fruit flies in this kind of study is a revelation to the researchers who view it as an efficient model for the initial testing of "rescue" therapies to try to prevent birth defects. Scientists can study the effect of the drug on the genes of as many as three generations of fruit flies in a month using readily available scientific tools, speeding up study times while keeping costs low.

"It also adds to the growing list of roles fruit flies can take," says Walker. Fruit flies are already used as models for aging, neural disease and cancer.


'"/>

Source:Queen's University


Related biology news :

1. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
2. Fruit fly studies open new window on cancer research
3. How Fruitflies Know Its Time for Lunch
4. Fruit flys beating heart helps identify human heart disease genes
5. Fruit fly reveals a potential connection between dementia and cancer
6. Fruit fly dating game provides clues to our reproductive prowess
7. Fruit fly aggression studies have relevance to humans, animals
8. Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine
9. Fruit fly study identifies gene mutation that regulates sensitivity to alcohol
10. Fruit flies and global warming -- Some like it hot
11. Fruit fly gene research may shed light on human disease processes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/25/2016)... Jan. 25, 2016   Unisys Corporation (NYSE: UIS ... F. Kennedy (JFK) International Airport, New York City ... identify imposters attempting to enter the United States ... them. pilot testing of the system at Dulles ... terminals at JFK during January 2016. --> pilot testing ...
(Date:1/22/2016)... , Jan. 22, 2016 ... addition of the "Global Biometrics Market ... their offering. --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ... "Global Biometrics Market in Retail Sector ... --> Research and Markets ( ...
(Date:1/20/2016)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is pleased to announce the attainment of record-setting corporate ... of the company,s laser focus on (and growing international ... comprehensive, easy-to-use and highly affordable cloud-based technology platform. ... growth achievements in 2015 include: , Record ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... ... February 04, 2016 , ... Shimadzu ... quad LC-MS, host live demos and poster sessions, and present on the analysis ... conference takes place March 6 to 10 at the Georgia World Congress Center ...
(Date:2/4/2016)... , Feb. 4, 2016 Beike Biotechnology, the ... medical institutions attended a ceremony in late 2015 to ... cell therapy in 2016. --> ... Translation Platform for Personalized Cell Therapy" was hosted by ... Production Center, both subsidiaries of Beike Biotechnology Co., Ltd. ...
(Date:2/4/2016)... British Columbia and MENLO PARK, Calif. ... (OTCQX: DMPI) ("DelMar" and the "Company"), a biopharmaceutical company ... today announced that it will present at the 18 ... Monday, February 8, 2016 at 10:00 a.m. EST in ... Bacha , DelMar,s president and CEO, will provide an update ...
(Date:2/4/2016)... Feb. 4, 2016 ContraVir Pharmaceuticals, Inc. (NASDAQ: ... development and commercialization of targeted antiviral therapies, announced today ... Conference 2016, to be held February 8-9, 2016, at ... 2016 Disruptive Growth & Healthcare Conference, taking place in ... 2016. James Sapirstein , Chief Executive Officer ...
Breaking Biology Technology: