Navigation Links
Front-line immune cells mature in four stages, study shows

Researchers here have cracked the site and the stages of development for the last major set of human immune cells.

The researchers found that natural killer (NK) cells, one of the body's front-line defenses against cancer and infections, mature from progenitor stem cells in four discrete stages. They also found that this happens in secondary lymphoid tissue such as tonsils and lymph glands.

Key discoveries made decades ago in animals and humans showed that the other two major types of immune cells in the body, T cells and B cells, developed in the thymus and bone marrow, respectively. However, the site and stages of human NK cell development have eluded investigators until now.

The findings advance the understanding of NK cells, which play a key role in triggering broader immune responses such as the body's permanent protection following vaccination. Understanding the secrets of NK cell development in humans could lead to new therapies for cancer, infection and for patients with immune deficiencies.

The study by researchers at the Ohio State University Comprehensive Cancer Center (OSUCCC) is published in the April 17 issue of the Journal of Experimental Medicine. Identification of the stem cell from which the human NK cell is derived was published by the OSUCCC research team last year in the journal Immunity.

"While there is a lot more work to do, this discovery unlocks another of Mother Nature's secrets," says principal investigator Michael A. Caligiuri, director of the OSUCCC and the Division of Hematology-Oncology.

"Still, we believe it opens new doors to manipulating the human immune system to our benefit, and we're working on that right now," says Caligiuri, who is also professor of internal medicine, of molecular virology, immunology and medical genetics and of veterinary biosciences.

"The findings will also boost NK-cell research," says first author Aharon G. Freud, a physician who is a doctoral st
'"/>

Source:Ohio State University


Page: 1 2

Related biology news :

1. Fox Chase Cancer Center scientists identify immune-system mutation
2. Genetically modified natural killer immune cells attack, kill leukemia cells
3. Studies reveal methods viruses use to sidestep immune system
4. Jumping gene helps explain immune systems abilities
5. Scientists solve structure of key protein in innate immune response
6. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
7. NYU study reveals how brains immune system fights viral encephalitis
8. Chemists identify immune system mechanism for methamphetamine binges
9. Multi-purpose protein regulates new protein synthesis and immune cell development
10. Genetic defects give the immune system the green light to attack the pancreas
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Front line immune cells mature four stages study shows

(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
(Date:4/17/2015)... , April 17, 2015 ... concerns, and technological advancement to drive biometric systems ... until 2020   According to a ... Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... to register growth at CAGR of over 22% ...
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... Singapore Immunology Network (SIgN) have discovered a new defense ... The team,s discovery of how a novel protein unexpectedly ... also be used to get rid of tumour cells. ... Basel, Switzerland, published in July 2013 in Nature ...
... -- Clearly Innovative Home and Office Products, a company that ... and high quality products including glass chair mats , ... the Midwest. (Photo: http://photos.prnewswire.com/prnh/20130909/MN76072 ) ... it has worked hard to develop and market products that ...
... Scientists have developed a strain of the Middle East respiratory ... against the disease, according to a study to be published ... American Society for Microbiology. The mutant MERS virus, rMERS-CoV-ΔE, has ... of infecting a cell and replicating its genetic material, but ...
Cached Biology News:Novel mechanism discovered in first line of immune defense 2Chair Mats of Glass Company Clearly Innovative Announces the Launch of 20 New Dealers in the Midwest 2Scientists engineer strain of MERS coronavirus for use in a vaccine 2Scientists engineer strain of MERS coronavirus for use in a vaccine 3
(Date:5/21/2015)... , May 21, 2015 /PRNewswire/ - SQI Diagnostics ... life sciences company that develops and commercializes proprietary technologies ... financial and operational results for the second fiscal quarter ... quarter the Company continued to advance business with our ... Andrew Morris , President and CEO of SQI. "The ...
(Date:5/21/2015)... May 21, 2015  Susan Hedstrom, Executive Director ... nonprofit organization dedicated to supporting research to advance ... announced today that FPWR has received the organization,s ... Shaulov contributed $1 million in support of ... "Our gift signifies ...
(Date:5/21/2015)... , May 21, 2015  The EveryLife Foundation ... (R-UT) and Amy Klobuchar (D-MN) ... Accelerating Cures & Treatments, or OPEN ACT. ... patient advocacy organizations, this bipartisan legislation promises to ... medicines to rare disease patients by incentivizing drug ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Patent Offering, ... method for diagnostic or therapeutic imaging within a body ... uses an endoscope having a low cost, single-use disposable ... filing date was October 18, 2013 and the patent ... technology enables the physician to customize the lighting and ...
Breaking Biology Technology:SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3
... , BEIJING , June 1 ... in the development, assembly, marketing and,sale of medical products in China ... China of a sophisticated anesthesia product manufactured,by Penlon, a UK firm ... , , ...
... June 1 Oncimmune LLC, maker of ... in risk assessment and the early detection of lung ... and economic benefits of a standardized and reproducible autoantibody ... for lung cancer patients. Currently, lung cancer is responsible ...
... ... series into its curriculum. The online drug safety training courses from BioSoteria will ... and PhD students, postdoctoral fellows, and residents via the University of Maryland’s Blackboard system. ... Baltimore, ...
Cached Biology Technology:Dehaier Medical Systems Extends Product Offerings with Exclusive Distribution Agreement for Penlon Anesthesia System in North China 2Dehaier Medical Systems Extends Product Offerings with Exclusive Distribution Agreement for Penlon Anesthesia System in North China 3Dehaier Medical Systems Extends Product Offerings with Exclusive Distribution Agreement for Penlon Anesthesia System in North China 4Studies Demonstrate Early Stage Detection and Economic Benefits of a Blood-Based Test for Lung Cancer 2Studies Demonstrate Early Stage Detection and Economic Benefits of a Blood-Based Test for Lung Cancer 3Studies Demonstrate Early Stage Detection and Economic Benefits of a Blood-Based Test for Lung Cancer 4Studies Demonstrate Early Stage Detection and Economic Benefits of a Blood-Based Test for Lung Cancer 5Studies Demonstrate Early Stage Detection and Economic Benefits of a Blood-Based Test for Lung Cancer 6Studies Demonstrate Early Stage Detection and Economic Benefits of a Blood-Based Test for Lung Cancer 7University of Maryland School of Pharmacy Adopts BioSoteria's eLearning Drug Safety Courses 2University of Maryland School of Pharmacy Adopts BioSoteria's eLearning Drug Safety Courses 3University of Maryland School of Pharmacy Adopts BioSoteria's eLearning Drug Safety Courses 4
... High Five cells (BTI-TN-5B1-4) derived ... have been shown to be capable ... secreted recombinant proteins compared to other ... the following features:- -Rapid doubling time as ...
... Flipper® Racks are ideal for storage and ... These polypropylene racks withstand extreme temperatures, making ... They may also be autoclaved for use ... one side accommodates 0.5ml microcentrifuge tubes, the ...
... comprehensive, cost-effective solution to your TechMate ... quality into both our products and ... chemistries and antibodies that have been ... also includes our competitively priced accessories ...
... consists of universal lysis buffer, PCR mix, ... 100 25 l volume PCR reactions. This ... negative or positive rod and coccus bacteria, ... Cereus, Staphylococcus Aureus, Streptococcus Agalactiae, and etc. ...
Biology Products: