Navigation Links
Freeze! Scientists film proteins at work by freezing them at different states

It is difficult to find similarities between Grenoble and Hollywood or between the researchers at the ESRF and the Institut de Biologie Structural (IBS) and world-known filmmakers. However, scientists from these institutes based in Grenoble (France) have managed to produce a movie. The actors are not celebrities but a protein whose role is to eliminate toxic molecules. They filmed this protein in action by freezing it at several states. They publish their results this week in Science.

Most of the research done on proteins is based on their study in a resting state and their study in movement is extremely limited due to technological limitations. Today, a French team has made a movie of an enzyme (a protein that catalyses chemical reactions) found in bacteria. “The achievement of this research is two-fold: on one side there is the technological success of filming an enzyme in action and on the other hand there are the results that contribute to the knowledge of how this enzyme works? explains Dominique Bourgeois, corresponding author for the paper.

The enzyme filmed in action is called “superoxide reductase? its role is to eliminate a toxic molecule called “superoxide radical? In order to survive, all living organisms have to fight oxidative stress, produced by outflows of the oxygen metabolism. In humans, about 2% of the oxygen used to breathe is transformed into this toxic “superoxide radical?molecule, instead of water. This production is increased in people affected by neurodegenerative diseases such as Alzheimer. A high amount of these molecules worsen these illnesses, so scientists are looking for drugs to eliminate them.

The enzyme studied by the team acts uniquely in bacteria and its counterpart in humans is more complex. Synthesizing an enzyme like the one studied through biomimetics is an exciting possibility for developing future drugs.

In order to produce the film, the team used the ESRF-IBS “Cryobench?laboratory to fr
'"/>

Source:European Synchrotron Radiation Facility


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:9/30/2014)... reefs face a suite of perilous threats in ... development and climate change, fragile coral ecosystems are ... this trend, some species of corals surrounding the ... natural protector in their tropical environment: coral guard-crabs. ... History,s Smithsonian Marine Station scientist Seabird McKeon and ...
(Date:9/29/2014)... study confirms that the exposure to tar tended to ... regular cigarettes. Similarly, exposure to nicotine tended to ... type of cigarette in several countries around the world. ... toxic chemicals in the smoke of these cigarettes are ... levels of chemicals in the smoke are not necessarily ...
(Date:9/29/2014)... pizza in school? According to a new Food and ... chef-made meals can increase participation in the National School ... consumption of vegetables by 16%! , Chefs Move to ... campaign, pairs chefs with schools in order to provide ... school food service workers. , A CMTS event was ...
Breaking Biology News(10 mins):Smithsonian scientists discover coral's best defender against an army of sea stars 2Slim cigarette smokers not exposed to more harmful chemicals 2Chefs move to schools can increase school meal participation and vegetable intake among students 2
... Scientists aboard the Royal Research Ship James Cook have discovered ... waters of the Southern Ocean. The discovery is the ... suggests that deep-sea vents may be more common in our ... the researchers saw slender mineral spires three metres tall, with ...
... and Education (CARE) Unit ( www.bumc.bu.edu/CARE ) in the ... awarded a $1,886,087 renewal grant from the National ... to become sophisticated implementers of substance use screening, assessment ... renewal from the national institute on Drug Abuse to ...
... The more humanity acidifies and warms the world,s oceans ... to save our coral reefs. That,s the blunt message ... which finds that ocean acidification and global warming will combine ... the world,s coral reefs right when they are struggling to ...
Cached Biology News:More deep-sea vents discovered 2Acid oceans demand greater reef care 2
(Date:10/1/2014)... -- This report analyzes the worldwide markets ... the following Product Segments: Proteases, Polymerases, Carbohydrases, ... also analyzed are Pharmaceuticals & Diagnostics, Research/Biotechnology, ... separate comprehensive analytics for the US, Canada, ... America. Annual estimates and forecasts are provided ...
(Date:9/30/2014)... release is available in German . ... Technische Universitt Mnchen (TUM) have demonstrated a new kind ... show that future computer chips could be based on ... the main enabling technology of the semiconductor industry ... the TUM researchers and collaborators at the University of ...
(Date:9/30/2014)... Shimadzu Scientific Instruments has released ... highly precise tool for measuring displacement in rubber ... 1000-mm maximum movement distance, the DSES-1000 can measure ... length of 10 mm. In addition, it achieves ... stroke and within +/- 100 µm below 50-mm ...
(Date:9/30/2014)... 2014 Follow us on LinkedIn ... type of cholesterol carrier or lipoprotein in the blood. ... cholesterol levels in the body, especially along the walls ... attack and other cardiovascular disorders. Cardiovascular Diseases (CVD) is ... cholesterol levels on a regular basis, to assess an ...
Breaking Biology Technology:Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... N.Y., May 14, 2012  More than one billion people worldwide ... decrease in the ability of the lens in the eye ... all seen others struggle with trying to read menus and ... To combat this change in vision, which often begins around ...
... In its ongoing effort to help patients, ... detailed information about its NovoTTF™ therapy for recurrent ... Website, found at www.novottftherapy.com . ... the NovoTTF™-100A, a wearable device that ...
... Inc. (NYSE Amex: PTN ) a biopharmaceutical ... of diseases with significant unmet medical need and commercial ... March 31, 2012.  Palatin reported a net loss of ... for the quarter ended March 31, 2012, compared to ...
Cached Biology Technology:New Daily Disposable Multifocal Contact Lenses from CooperVision Offer Comfort, Performance, Health, and Convenience to Fit Your Life 2New Daily Disposable Multifocal Contact Lenses from CooperVision Offer Comfort, Performance, Health, and Convenience to Fit Your Life 3Novocure Announces Launch of Recurrent Glioblastoma Product Website 2Novocure Announces Launch of Recurrent Glioblastoma Product Website 3Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2012 Results; Teleconference and Webcast to be held on May 14, 2012 2Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2012 Results; Teleconference and Webcast to be held on May 14, 2012 3Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2012 Results; Teleconference and Webcast to be held on May 14, 2012 4Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2012 Results; Teleconference and Webcast to be held on May 14, 2012 5
Mouse monoclonal antibody raised against a partial recombinant ZNF155. NCBI Entrez Gene ID = ZNF155...
... macroporous polystyrene beads for hydrophobic interaction chromatography. ... adsorbing organics of molecular weight less than ... useful for the adsorption of nonpolar substances ... removal of detergents such as Triton X-100 ...
... : Fusion protein corresponding to ... human Mi-2 Formulation: 0.7M Tris-glycine, ... sodium azide, containing 30% glycerol ... immunoblot on Hela nuclear extract ...
... Phospho-Specific(Thr 222 ) ... 10 mM sodium HEPES, 100 ... 7.5. Recognizes the ~47 kDa ... (MAPKAPK-2) protein phosphorylated at Thr ...
Biology Products: