Navigation Links
Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

tal protective functions. Certain lung infections easily cleared from normal laboratory mice are a death sentence for those lacking gamma-delta T cells.

Despite their clear importance in resisting disease, the processes controlling the generation of gamma-delta T cells have remained mysterious until recently. As Robert Frost put it, Wiest pointed out:
"Two roads diverged in a wood, and I--
I took the one less traveled by,
And that has made all the difference."

"Gamma-delta T cells represent the road less traveled," Wiest said. "However, the role of the TCR in determining lineage is controversial, particularly whether different forms of TCR predetermine a cell's fate and whether or not their signals control the choice."

In the new study, Wiest and his colleagues use several models to manipulate the signaling strength of the gamma-delta TCR. A strong signal, produced in the presence of a specific binding substance, or ligand, directs immature T cells almost exclusively to the gamma-delta lineage. However, weakening the signal promotes alpha-beta lineage development.

"The signal strength determines the level of expression of early growth response (Egr) proteins, with cells choosing the gamma-delta lineage expressing far greater quantities of Egr proteins than those adopting the alpha-beta lineage," explained Wiest. "Egr proteins regulate which cellular genes are turned on or off so we think that high-level expression of Egr proteins instructs cells to express the set of cellular genes necessary to become a gamma-delta T cell."

Understanding the development of critical components of the immune system can lead to scientific and medical advances in stimulating desirable immune responses and halting unwanted ones.

"Although their precise function is still unclear, delta-gamma T cells seem to form the first line of response against external disease-causing agents, including bacterial infections, tissue damage
'"/>

Source:Fox Chase Cancer Center


Page: 1 2 3

Related biology news :

1. Fox Chase Cancer Center scientists identify immune-system mutation
2. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
3. Bioartificial kidney under study at MCG
4. W.M. Keck Foundation funds study of friendly microbes
5. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
6. Genome-wide mouse study yields link to human leukemia
7. Clam embryo study shows pollutant mixture adversely affects nerve cell development
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. Same mutation aided evolution in many fish species, Stanford study finds
10. Sequencing of marine bacterium will help study of cell communication
11. Genetically modified rice in China benefits farmers health, study finds
Post Your Comments:
(Date:7/24/2008)...The University of Iowa and Iowa State University a...e both institutions, genetic research capabilities...assively parallel DNA sequencer an instrument cap...illions to billions of bases in a single run. The ... available on a fee-for-service basis to researche...
(Date:7/24/2008)...yphoon in Taiwan buries as much carbon in the ocea...ains in that country all year long combined. , ...dy published in a recent issue of the journal Geo...the chemistry of stream water and sediments that w...ppening at full force -- will help scientists deve...
(Date:7/23/2008)...into a domestic renewable fuel source could genera... of North America,s entire consumption needs and l...missions (GHGs), according to US research publishe...ysics, Environmental Research Letters . , The j... Benefits of Converting Manure to Biogas, has imp...
(Date:7/23/2008)...ons willing to collectively spend about $1 billion...lf a billion metric tons of carbon dioxide per yea..., It would take about that much money to put an e... world, one of the top contributors to greenhouse ...d, this type of program could have potential to re...
Breaking Biology News(10 mins):UI and ISU establish shared DNA sequencing instrumentation 2UI and ISU establish shared DNA sequencing instrumentation 3Study: Typhoons bury tons of carbon in the oceans 2Study: Typhoons bury tons of carbon in the oceans 3Study: Typhoons bury tons of carbon in the oceans 4Cow power could generate electricity for millions 2Paying to save tropical forests could be a way to reduce global carbon emissions 2Paying to save tropical forests could be a way to reduce global carbon emissions 3Paying to save tropical forests could be a way to reduce global carbon emissions 4Message to Idaho Residents 3A Forgo Fad Dieting and Join the Campaign for Healthy Weight 20521 1Message to Idaho Residents 3A Forgo Fad Dieting and Join the Campaign for Healthy Weight 20521 2Message to Idaho Residents 3A Forgo Fad Dieting and Join the Campaign for Healthy Weight 20521 3Sun Pharma Responds to Taros Purported Termination of Merger Agreement 20516 1Sun Pharma Responds to Taros Purported Termination of Merger Agreement 20516 2Sun Pharma Responds to Taros Purported Termination of Merger Agreement 20516 3Sun Pharma Responds to Taros Purported Termination of Merger Agreement 20516 4Sun Pharma Responds to Taros Purported Termination of Merger Agreement 20516 5Sun Pharma Responds to Taros Purported Termination of Merger Agreement 20516 6Sun Pharma Responds to Taros Purported Termination of Merger Agreement 20516 7Post menopausal therapy to improve womens quality of life 20512 1Post menopausal therapy to improve womens quality of life 20512 2Alsius Corporation Awarded Three Year Agreement With Premier Inc 20507 1Alsius Corporation Awarded Three Year Agreement With Premier Inc 20507 2Alsius Corporation Awarded Three Year Agreement With Premier Inc 20507 3
...ized that birds possess the ability to use the Ear... just how this is done has not yet been clarified....ures in the beaks of homing pigeons in a new study...University of Frankfurt offers a promising insight...lished online mid-March in Springer’s journal Natu...
...n on smoking in Ireland resulted in an 83 percent ...decrease in airborne carcinogens for patrons and s... of bar workers, according to a one-year follow-up... for April 2007 of the American Journal of Respira...American Thoracic Society. , Luke Clancy, M.D.,...
...iscovered by Queen’s University researchers may be...sistant bacteria, such as those that cause food po...nd activity of the protein ?called YihE or RdoA ?a...nts of Biochemistry and Microbiology & Immunol...opment. , “Our group is the first to solve the...
...use their vision for piloting, just like human pil... travel through specialized neurons to stimulate t...ir flight and avoid crashes. Could these same neur...s what Nicolas Franceschini, Franck Ruffier and Ju...cialists from the Movement and Perception Laborato...
Other Biology News:Homing pigeons get their bearings from their beaks 2Smoking ban dramatically reduces air pollution in Irish pubs 2Smoking ban dramatically reduces air pollution in Irish pubs 3Protein discovery targets antibiotic-resistant bacteria 2Is there a pilot in the insect? 2Is there a pilot in the insect? 3
(Date:7/24/2008)...re/ -- The Global Probiotics Council,(GPC), a comm...ult Honsha,Co., Ltd., announced the two awardees w...rant for Probiotics Research (YIGPRO) today. The p...who will continue to contribute to,the advancement...United,States., Ajay S. Gulati, MD, an Assistant ...
(Date:7/24/2008)... Important Advance in Radiofrequency ...if., July 24 /- PEAK Surgical, Inc., ...tissue dissection system,based on a proprietary te...rug Administration has granted the company 510(k) ... use in general surgery. The PEAK Surgery System,c...
(Date:7/24/2008)...ire/ -- Sagent Pharmaceuticals, Inc.,a privately-...nced that it,has launched ceftazidime for injectio...m antibiotic. Sagent will offer ceftazidime in 1,a...ge vials. According to,IMS data, 2007 sales of inj...ximately $45.7 million., "Sagent is proud to be p...
(Date:7/24/2008)...swire-FirstCall/ -- United,Therapeutics Corporatio...lease its 2008 second quarter financial results be...., United Therapeutics will host a half-hour tele.... Eastern Time. The teleconference is accessible,b...rs dialing,1-706-679-8129. A rebroadcast of the te...
Breaking Biology Technology:Global Probiotics Council Announces First Awardees for New Young Investigator Grant for Probiotics Research 2Global Probiotics Council Announces First Awardees for New Young Investigator Grant for Probiotics Research 3Global Probiotics Council Announces First Awardees for New Young Investigator Grant for Probiotics Research 4PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in General Surgery 2PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in General Surgery 3PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in General Surgery 4Sagent Pharmaceuticals Launches Ceftazidime for Injection, USP 2
...l technology subsidiary of Marshall & Ilsley Corp...., of Herndon, Va.-based TREEV, LLC, a provider o...e financial industry. The company delivers browser...both lending and deposit environments. TREEV will ...s (AFS), a Metavante company. , ,"The acquisition ...
...llaborate with the Harvard Center for Neurodegene...aging system, the IN Cell Analyzer, to enhance res...odegenerative diseases like Parkinson,s and Alzhei..., ,In addition, the Harvard center and GE will wor... help speed disease analysis in the lab. , ,GE He...
...cial technology subsidiary of Marshall & Ilsley Co...une, of Wayne, Pa.-based GHR Systems, Inc. , a pr...ential mortgage and consumer finance industries th... underwriting, processing and closing technology. ... , ,GHR,s client base includes four of the top 10 ...
...ust be done in a holistic manner if the efficienci...uly realized, attendees at Friday,s premiere of UW...from Patrick Sweeney, CEO of Virginia-based ODIN ...gave the keynote address at the lab,s open house -... RFID in action. , ,The lab, within the Engineerin...
Other Biology Technology:RFID expert says piecemeal approach won't work 2RFID expert says piecemeal approach won't work 3RFID expert says piecemeal approach won't work 4
Standard 2" and 3" Fiberboard Boxes can be sold separately or with 16, 25, 36, 49, 64, 81 or 100 cell dividers. Fiberboard boxes can also be ordered with corresponding freezer racks
Whole blood is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -
Anti-HMGN2/HMG-17 Immunogen : Recombinant human HMGN2/HMG-17 Formulation: 0.2M Tris-glycine, pH7.4, 5mg/ml BSA, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% Quality Assuranc
...MMP-3, Human, Assay, 96 wells. ELISA.Specific for...d complexed MMP-3. No cross-reactivity with MMP-1,...ng/ml.Suitable for use with cell culture supernata...l.Store at -15 to -30 C. Category: Drug Screening...
Biology Products: