Navigation Links
Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

tal protective functions. Certain lung infections easily cleared from normal laboratory mice are a death sentence for those lacking gamma-delta T cells.

Despite their clear importance in resisting disease, the processes controlling the generation of gamma-delta T cells have remained mysterious until recently. As Robert Frost put it, Wiest pointed out:
"Two roads diverged in a wood, and I--
I took the one less traveled by,
And that has made all the difference."

"Gamma-delta T cells represent the road less traveled," Wiest said. "However, the role of the TCR in determining lineage is controversial, particularly whether different forms of TCR predetermine a cell's fate and whether or not their signals control the choice."

In the new study, Wiest and his colleagues use several models to manipulate the signaling strength of the gamma-delta TCR. A strong signal, produced in the presence of a specific binding substance, or ligand, directs immature T cells almost exclusively to the gamma-delta lineage. However, weakening the signal promotes alpha-beta lineage development.

"The signal strength determines the level of expression of early growth response (Egr) proteins, with cells choosing the gamma-delta lineage expressing far greater quantities of Egr proteins than those adopting the alpha-beta lineage," explained Wiest. "Egr proteins regulate which cellular genes are turned on or off so we think that high-level expression of Egr proteins instructs cells to express the set of cellular genes necessary to become a gamma-delta T cell."

Understanding the development of critical components of the immune system can lead to scientific and medical advances in stimulating desirable immune responses and halting unwanted ones.

"Although their precise function is still unclear, delta-gamma T cells seem to form the first line of response against external disease-causing agents, including bacterial infections, tissue damage
'"/>

Source:Fox Chase Cancer Center


Page: 1 2 3

Related biology news :

1. Fox Chase Cancer Center scientists identify immune-system mutation
2. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
3. Bioartificial kidney under study at MCG
4. W.M. Keck Foundation funds study of friendly microbes
5. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
6. Genome-wide mouse study yields link to human leukemia
7. Clam embryo study shows pollutant mixture adversely affects nerve cell development
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. Same mutation aided evolution in many fish species, Stanford study finds
10. Sequencing of marine bacterium will help study of cell communication
11. Genetically modified rice in China benefits farmers health, study finds
Post Your Comments:
(Date:11/21/2014)... DALLAS , November 18, 2014 ... Security Systems Market by Systems (Video, RFID, Access Control, ... (SEZ, Factories, Hotels, Banks, Government), Component Service Geography - ... Security Systems Market is projected to be around $25 ... Billion by 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... NEW YORK , Nov. 19, 2014  Earlier ... Board at New York College, and one of the ... for biosensor signals that are transmitted from Smartphones to ... there were Smartphones and has one of the earliest ... are discussing its usage in the military, child care, ...
(Date:11/21/2014)... 2014 Strict laws against distracted driving and ... North American and European automotive sector towards gesture recognition ... systems that are intuitive and able to retrieve information ... New analysis from Frost & Sullivan,s ... Europe and North ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... medical woes ranging from cancer to bird flu will ... The newly-patented device will offer small and medium-sized researchers ... It will also allow them a chance, at last, ... analyze drugs and view the characteristics of protein. ...
... a gene known to increase the risk of Alzheimer,s ... Oregon Health & Science University study has found. ... that 7- to 10-year-olds with a member of a ... and neuroprotection display reduced spatial learning and memory, associated ...
... include: continental deformation and the San Andreas fault; ... between Britain and America; environmental stress and the ... Canada,s Mackenzie River basin as a CO2 source ... the absence of active volcanism; and geologic evolution ...
Cached Biology News:Council to honor NJIT SmartPin 2Children with gene show reduced cognitive function 2November GEOLOGY and GSA TODAY Media Highlights 2November GEOLOGY and GSA TODAY Media Highlights 3November GEOLOGY and GSA TODAY Media Highlights 4November GEOLOGY and GSA TODAY Media Highlights 5November GEOLOGY and GSA TODAY Media Highlights 6November GEOLOGY and GSA TODAY Media Highlights 7November GEOLOGY and GSA TODAY Media Highlights 8November GEOLOGY and GSA TODAY Media Highlights 9November GEOLOGY and GSA TODAY Media Highlights 10
(Date:11/27/2014)... Spartan Bioscience today announced that it has ... (MFDS) regulatory approval for its Spartan RX CYP2C19 ... than 60 minutes from a non-invasive cheek swab. , ... doctors to determine therapeutic strategies for drugs metabolized by ... the world’s most commonly prescribed drugs such as Plavix® ...
(Date:11/27/2014)... England , November 27, 2014 ... online on ScienceDirect   Elsevier , ... products and solutions, is pleased to announce the launch ... . The launch of ... the rapid advances at the forefront of applied sciences ...
(Date:11/27/2014)... -- Calcivis, a medical devices company ... today announces that it has completed a first ... System. The Calcivis Caries Activity Imaging ... combination designed to transform the assessment and management ... unique, proprietary bioluminescence approach combined with a specialised ...
(Date:11/27/2014)... Washington, and PITTSFIELD, Massachusetts, USA (PRWEB) November 26, 2014 ... cancer cells with more accuracy, additive systems to enable ... highway safety by analyzing road conditions are among finalists ... for Photonics Innovation . The awards are sponsored by ... , and Photonics Media . , Winners will ...
Breaking Biology Technology:Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs 2Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs 3Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 2Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 3Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 2Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 3Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5
... required regulatory approvals for the $2.3 billion acquisition of ... divest of two divisions of the company they are ... manufacturer plans to integrate Instrumentarium it into its ... CEO, Dow Wilson.. , ,The final required ...
... to open a new state-of-art healthcare facility in October, ... latest in digital imaging technology from technology vendor Emageon. ... and distribution of digital medical images across its integrated ... in 1984 is a nationally recognized leader in efforts ...
... Internet connection? , ,MADISON, WI - McDonalds ... connections in five Milwaukee locations as part of a ... restaurants in the San Francisco Bay Area, Metropolitan New ... McDonald's Wireless Internet service. , ,Customers can purchase an ...
Cached Biology Technology:Aurora Selects New Imaging Technology 2Wisconsin McDonalds Go Wireless 2
... Edition of Molecular Imaging (MI) Software for ... science research and drug discovery applications. The ... Food and Drug Administrations Code of Federal ... Electronic Signatures [21 CFR Part 11]. KODAK ...
... Tissue Arrays are intended for laboratory research ... fixed in neutral buffered formalin and embedded ... was performed by certified pathologists. Tissue ... and relocated into a new recipient paraffin ...
... industry standard microarray image analysis software because ... analysis tools, visualizations, automation capabilities, performance and ... with every GenePix scanner, and it also ... all types of arrays. A wide range ...
... applications not requiring confocal, the BD Pathway ... the Pathway 435. And, the Pathway 415 ... applications require it. High-performance, ... to use the laser autofocus, camera autofocus, ...
Biology Products: