Navigation Links
Found: Missing sequence of the human Y chromosome

centromeric region of the Y chromosome. This sequence contains a 450-kilobase "euchromatic island" with eight presumably active genes flanked by repetitive satellite sequences. To ensure that this 554-kilobase sequence was in fact missing from the "finished" human genome sequence and was not a structural polymorphism present only in a subset of males in the human population, members of Rappold's laboratory ?including Stefan Kirsch, Ph.D., lead author on the paper ?tested 100 men of different ethnic origin for the presence of this 554-kilobase fragment. Indeed, the sequence was present in all 100 individuals tested, but not in any female controls, confirming that this sequence was a fundamental part of the Y chromosome. More surprising, however, was Rappold's finding that this "missing" sequence was not unique to the Y chromosome. Rather, this sequence exhibited between 95-99% homology to sequences on exactly half (11 of 22) of the other chromosomes in the human genome, including the pericentromeric regions of autosomes (non-sex chromosomes) 1, 2, 3, 4, 9, 10, 11, 14, 15, 16, and 22. This remarkable similarity can be attributed to segmental duplications, a phenomenon whereby large portions of the genome are copied during evolution. Segmental duplications, which emerged during the past 30 million years of primate evolution, are significantly enriched in subtelomeric and pericentromeric sequences, and now comprise approximately 5% of the human genome, were considered to be one of the biggest obstacles to finishing the human genome sequence. "The identification of these segmental duplications suggests an underrepresentation of pericentromeric regions of the acrocentric chromosomes in the current human genome sequence," Rappold pointed out. The current study was designed as part of a long-term effort to characterize the molecular genetic basis for Y-chromosome-linked phenotypes. Rappold and colleagues had previously physically mapped the GCY locus, which is thought to be
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2 3

Related biology news :

1. Missing Receptor Molecule Causes Tumor Growth
2. Missing fossil link Dallasaurus found
3. Viral DNA sequence a possible trigger for breast cancer
4. GATA: a graphic alignment tool for comparative sequence analysis
5. Researchers uncover sequence of major rice pathogen
6. Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays
7. Oldest fossil human protein ever sequenced
8. Deep thinking: Scientists sequence a cold-loving marine microbe
9. Genomic sequences processed in minutes, rather than weeks
10. Public collections of DNA and RNA sequence reach 100 gigabases
11. Three deadly parasite genomes sequenced
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Found Missing sequence the human chromosome

(Date:8/29/2014)... is available in German . ... between organisms is considered the oldest form of communication. ... conspecifics, for example, the sexual attraction between males and ... and to coordinate reproductive behavior in males and females. ... of the Algarve in Faro, Portugal, and at the ...
(Date:8/29/2014)... a cell,s nucleus, chromosomal DNA is tightly bound ... biologists call chromatin. Until about two decades ago, ... mere packing material around which the glamorous DNA ... a greater appreciation for how DNA/histone interactions govern ... research institutions studying the sequence of the genome ...
(Date:8/29/2014)... USA - The rise of the Tibetan plateau -- ... -- is important for both its profound effect on ... study published in GSA Bulletin , Katharine Huntington ... isotope thermometry -- using modern and fossil snail shells ... in southwestern Tibet. , Views range widely on ...
Breaking Biology News(10 mins):Ready for mating at the right time 2Ready for mating at the right time 3'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... ARLINGTON, Va. - Aiming to motivate researchers to help ... Office of Naval Research (ONR) announced nine winners of an ... Forum. The recipients, whose projects range from microbial to ... their research area, said Dr. Rich Carlin, who heads ONR,s ...
... Researchers at the University of Illinois have developed a ... greenhouse gas emissions that results from changes in land ... Global Change Biology , takes into account many ... There is an urgent need to accurately ...
... led by Queen,s University biologists has found that potent ... feeding in the ocean, end up in the sediment ... diets will funnel different ,cocktails, of metal contaminants from ... affect other living organisms," says lead author Neal Michelutti, ...
Cached Biology News:Winners of ONR's Energy Challenge to help Navy reduce its carbon footprint 2Researchers calculate the greenhouse gas value of ecosystems 2Researchers calculate the greenhouse gas value of ecosystems 3Coastal birds carry toxic ocean metals inland 2
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
(Date:8/28/2014)... , Aug. 28, 2014   SunTrust Robinson Humphrey ... industry veterans to its equity research team in ... ongoing expansion in equity research demonstrates our commitment ... insights to enhance their investment decision making," said ... STRH.  "We continue to make significant investments in ...
(Date:8/28/2014)... 2014 Scientists, researchers, and technologists will ... Laser Damage 2014 symposium. Marking its 46th year, ... will run 14-17 September. The event is sponsored by ... . , The premier conference for basic and applied ... optical materials will engage researchers and engineers from numerous ...
(Date:8/28/2014)... August 28, 2014 Supplementing their ... a promotion for Eppendorf Safe Lock Centrifuge ... purchase the highest quality tubes at an affordable ... for customers doing chemical, medical, pharmaceutical, and life ... are not regularly able to afford Eppendorf products. ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... BD (Becton, Dickinson and Company) (NYSE: BDX ... its third fiscal quarter 2009 earnings conference call on Thursday, July ... press release detailing the quarter,s earnings earlier that morning. , ... will be accessible through BD,s website at www.bd.com/investors ...
... Kendle (Nasdaq: KNDL ), a leading, global ... Jarrod Pontius to the position of Chief Legal Officer. ... for all legal services, corporate governance and general corporate ... in Kendle,s global headquarters in Cincinnati and will report ...
... New Sequence Data into Biochips for Gene Expression Profiling ... , LEXINGTON, Mass. and HEIDELBERG, Germany, June 29 ... today the launch of the first biochip on the ... biochip from febit enables up-to-date profiling and enrichment of ...
Cached Biology Technology:Kendle Names Jarrod Pontius Chief Legal Officer 2febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment 2febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment 3
... Kit with CyScribe GFX Purification Kit, ... purification of Cy3- and Cy5-labeled cDNA.Optimized ... cDNA labeling and purification.Flexible and optimized ... labeling reactions with either Cy3- or ...
... ISO 9001:2000 Certified USDA Research Registered OLAW ... Training AALAS Certified Technicians ... GLP Documentation Upon Request Focus ... for all your custom immunology service needs. ...
Homo sapiens toll interacting protein Antigen: Recombinant Protein...
B3-1...
Biology Products: