Navigation Links
Forgotten by evolution?

Not least because undifferentiated cells with features typical of stem cells are being increasingly found in organs like the liver, brain, and muscles, scientists are beginning to assume that these cells play a role in repairing organs. Researchers from the Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany have now demonstrated, in a study published in the journal Molecular and Cellular Biology, that at least some adult stem cells could be the mere remnants of former embryonal differentiation processes, or, in other words, "footprints" of evolution. (Molecular and Cellular Biology, November 2005)

The scientists belonging to Thomas Braun's working group used as a basis for their research two cell lines of mesenchymal stem cells which had been isolated from the bone marrow of mice. What was particularly special about the process they used was that they did not add growth factors to the culture medium; the goal was to prevent the cells from differentiating prematurely. By doing so, the scientists discovered that the two cell lines were different in the expression of typical stem cell markers. The researchers thus suspect that mesenchymal stem cells are a heterogeneous group of various, different cells, that have similar characteristics.

As was hoped, the scientists, using certain substances, were able to bring the stem cell line to express proteins characteristic of muscle cells. Interestingly, when a particular path, known as the wnt-signal path, was stimulated, the cells began to develop the features of heart muscle cells. In contrast, when they were beforehand stimulated with a protein known as CDO, the cells showed certain characteristics of skeleton muscle cells.

In both experiments, a row of muscle-specific genes was activated in the cells. This provided evidence for the beginnings of a differentiation process. But this process was only apparently halfway complete. So, for example, after the activation of the wnt-sign
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2

Related biology news :

1. Overbearing colored light may reveal a second mechanism by which birds interpret magnetic signals
2. Bacteria which sense the Earths magnetic field
3. Researchers reveal mystery of bacterial magnetism
4. Study to explore using magnets to correct sunken chest
5. Using nanomagnets to enhance medical imaging
6. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
7. Source of molecular triggers in cutaneous T cell lymphoma identified
8. Plants, animals share molecular growth mechanisms
9. NYU researchers simulate molecular biological clock
10. Scientists reveal molecular secrets of the malaria parasite
11. Scientists identify molecular events that drive cell senescence
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Forgotten evolution

(Date:5/23/2013)... 23, 2013) A new report from the Institute ... pupils engage in at least 60 minutes of vigorous ... No more than half of American youth meet current ... or moderate intensity physical activity daily, according to the ... are in school for nearly half of their waking ...
(Date:5/23/2013)... In an age when microbial pathogens are growing increasingly ... infection, a team of Wisconsin scientists has synthesized a ... bacteria that cause staph infections. , Writing online in ... a group led by University of Wisconsin-Madison chemistry Professor ... "quorum sensing" behavior of Staphylococcus aureus , a ...
(Date:5/22/2013)... a major new effort to educate the public and ... with clean water that looms ahead in the 21st ... the current edition of Chemical & Engineering News ... (ACS), the world,s largest scientific society. , Bassam Z. ... Schnoor, Ph.D., explain that shortages of reliable supplies of ...
Breaking Biology News(10 mins):Schools should provide students with daily physical activity, IOM recommends 2University of Wisconsin chemists find new compounds to curb staph infection 2
... 2012 -With the help of funding from the March of ... to questions such as how cellular-level processes that control uterine ... how air pollution may affect pregnancy and preterm birth - ... babies will get a healthy start in life. ...
... of two different molecules in cancer is an effective ... scientists at the University of California, San Francisco (UCSF) ... treatments that include drugs like Avastin. The ... cancer known as neuroendocrine pancreatic tumors, may have broad ...
... This release is available in German . ... recent years in increasing quantities as substitutes for CFCs, are ... In the renowned journal Science an international team ... also be regulated. This could save the positive side effect ...
Cached Biology News:March of Dimes provides $3 million in new funding for preterm birth research 2March of Dimes provides $3 million in new funding for preterm birth research 3Cancer therapy more potent when it hits 2 targets 2Cancer therapy more potent when it hits 2 targets 3Protecting the climate by reducing fluorinated greenhouse gas emissions 2Protecting the climate by reducing fluorinated greenhouse gas emissions 3
(Date:5/23/2013)... Miami, FL (PRWEB) May 23, 2013 ... made trips to supermarkets to search for the ... grocery store aisles. Results from a year long study ... bacteria level in foods, specifically meats, over previous years. ... explains how the growth of antibiotic resistant bacteria in ...
(Date:5/23/2013)... 23, 2013 The New Jersey chapter ... Black Data Processing Associates (BDPA), is hosting its 10th ... 2013. This all-day event will encourage students and their ... ins and outs from many of the industries’ finest ... the New Jersey Institute of Technology, the event will ...
(Date:5/23/2013)... 23, 2013 During the conduct ... to adhere to principles of good clinical practice ... speaker Dr. Jeremy Lim, Fellow, Clinical Development at ... ,     Understand the International Conference on Harmonization ... additional regulations for the conduction of clinical trials ...
(Date:5/23/2013)... 23, 2013 African Ancestry ... for people of African descent, today announced new ... For people of all races, myDNAmix determines various ... distinct populations: Indigenous Americas (Native American), East Asia, ... , Originally launched in late 2011, ...
Breaking Biology Technology:Acne Cream, Probiotic Action Shares News on How Some Food may Breed Acne Causing Bacteria 2Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Adhering to Good Clinical Practice, New Webinar Hosted by Xtalks 2AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 2AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 3
... a software project was, and we will often hear, Oh, ... of time. How big was another 11,000-hour project that was ... that produced only a little bitof software, but software that ... but without a measurable ounce of software, we're left with ...
... Wis . - As the adoption of healthcare information technology continues ... than others are resolved. , ,The progress that has been made, ... the annual Digital Healthcare Conference set for May 9 ... Wisconsin-Madison campus. , , Dr. Barry Chaiken ...
... transaction that could mean network expansion and improved service, Madison's wireless ... Mad City Broadband was acquired by Louis Kek, the former ... Madison Capital Times . Kek will serve as CEO and ... deployed a year ago in a 10-square-mile area around the State ...
Cached Biology Technology:Defining the X-factor: What is an ounce of software worth? 2Defining the X-factor: What is an ounce of software worth? 3Defining the X-factor: What is an ounce of software worth? 4Digital Healthcare Conference 2007: Mounting obstacles for health IT 2Digital Healthcare Conference 2007: Mounting obstacles for health IT 3
... The DNA120 is a dedicated concentrator ... methanol/ethanol precipitates of DNA/RNA. The integrated system ... vacuum pump. The compact design, automatic pump ... for run time; one for heater time), ...
... The Jouan RC Standard MB (For ... other molecular biology samples) of vacuum concentrator/centrifugal ... molecular biology and biochemistry for rapid and ... systems can be expanded with pumps, different ...
... Jouan RC10 series of vacuum concentrators/centrifugal evaporators ... features allied to rapid and safe concentration ... be combined with oil-free or high vacuum ... a wide selection of rotors (eliminating sample ...
For relative and/or absolute quantification with standard accuracy requirements using MS or NMR instruments...
Biology Products: