Navigation Links
For the first time: Longevity modulated without disrupting life-sustaining function

eir larval development and reproduction were disrupted.

"So, the central question became whether we would be able to genetically manipulate one element of the pathway without disrupting its additional functions," said Dillin. "In this regard, we thought that the life extending function of this pathway would be elusive, whereas the developmental and reproductive functions would be more amenable. We were delighted to find that Smk-1 proved to be specific for the one function we thought the most elusive," he added.

Some of Dillin's earlier research had hinted at the possibility that "specificity" factors may control how and whether insulin and IGF-1 impact a target gene. Identifying those factors one by one would allow scientists to separate the different functions of insulin/IGF-1 signaling and to manipulate them individually without wreaking havoc on the organism's normal functioning.

Together with the lab of another Salk scientist, Tony Hunter, Ph.D., Dillin's team identified a protein in the worm Caenorhabditis elegans that allowed them to do just that. The protein is encoded by the Smk-1 gene. "Smk-1 is the first known gene that regulates longevity without affecting other vital functions of the insulin signaling pathway," said Wolff.

Under favorable conditions, a still unidentified molecule binds to DAF-2, the worms' equivalent of the insulin/IGF-1 receptor, which is located at the cell's surface. A cascade of signaling molecules relays the information deep into the cell till it reaches a protein called DAF-16. Known as a transcription factor, DAF-16 encodes a DNA-binding protein that turns on other genes but when DAF-2 is active, it is unable to enter the cell's nucleus to activate its target genes.

When environmental conditions turn harsh as a result of overcrowding and scarce nutrients, for example, DAF-2 signaling shuts down. No longer marooned outside the nucleus, DAF-16 crosses into the nucleus, and triggers all the
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. A genes first kiss sets off that affair known as puberty
2. Love at first smell
3. Worlds largest rainforest drying experiment completes first phase
4. PCRM develops worlds first cruelty-free insulin assay
5. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
6. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
7. DuPonts first biologically derived polymer receives global recognition
8. Anti cancer virotherapy well tolerated in first human administration, research finds
9. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
10. The first impact factor for PLoS Biology ?13.9
11. Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
Post Your Comments:
(Date:5/20/2015)... , May 20, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/h8t4x6/5year ) has announced the addition ... the Global Iris Recognition Market"  report ... , ,This research service analyses trends ... the government and commercial sectors, globally. ...
(Date:5/19/2015)... , May 18, 2015 Fingerprint Cards ... FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if its ... until and including Q3 2015 and the sensors will be ... Communicated order values for 2015 hereby amount to 740 MSEK ... 2015 of 140 MSEK and a number of smaller orders ...
(Date:5/19/2015)... , May 19, 2015 ... announced the addition of the  "Genetic Testing ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, ... in-depth analysis of the current and future ... gene-based tests, their working principles and types ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Global Genetic Testing Market Outlook 2018 2
... UT Dallas researchers have demonstrated that treating tinnitus, or ringing ... and brought significant improvement to some of the participants in ... Kilgard of the School of Behavioral and Brain Sciences used ... tones to alleviate the symptoms of chronic tinnitus. Their results ...
... weapon in the battle against childhood obesity, says a new Cornell ... which found children not only ask for more food to fill ... "The quickest way parents can help kids eat less might be ... behavioral economics and the lead author. "Make it 12 ounces rather ...
... Huanglongbing (HLB) or citrus greening is a ... , and poses a serious threat to the citrus ... by disrupting the trees, food transportation systems. To ... that rapidly characterize citrus varieties and hybrids and locate ...
Cached Biology News:UT Dallas study: Initial success for new tinnitus treatment 2Geneticists receive funding to improve citrus production and health 2Geneticists receive funding to improve citrus production and health 3
(Date:6/3/2015)... Calif. , June 3, 2015 The ... life of myeloma patients while working toward prevention and ... Annual International Myeloma Working Group (IMWG) Summit June 8-10 ... 100-plus IMWG members will attend the 2015 Summit, which ... the European Hematology Association (EHA).  The focus of the ...
(Date:6/3/2015)... Longmeadow, Mass. (PRWEB) June 03, 2015 ... outsourced medical device manufacturing services for complex Class III ... to support a new UT Dallas-led initiative aimed at ... of Texas System institutions and moving them more ... CIRTEC has a long history of working with the ...
(Date:6/3/2015)... Tennessee (PRWEB) June 03, 2015 Green ... in Milan, Tennessee to support the RCBC Waste to ... is fourth generation in the family business, http://www.greenearthwaste.com ... 1908. His family added recycling to their waste ... and recycling services to the Fortune 500 companies with ...
(Date:6/3/2015)... 2015 The National Center for ... record by scaling CD-adapco’s flagship simulation tool STAR-CCM+® ... , STAR-CCM+ is a comprehensive multidisciplinary engineering ... innovation and lower product development costs. CD-adapco joined ... manufacturer Cray to push the code to new ...
Breaking Biology Technology:International Myeloma Foundation Brings Together 100 of the World's Top Myeloma Experts June 8-10 in Vienna, Austria for 6th Annual Summit 2International Myeloma Foundation Brings Together 100 of the World's Top Myeloma Experts June 8-10 in Vienna, Austria for 6th Annual Summit 3International Myeloma Foundation Brings Together 100 of the World's Top Myeloma Experts June 8-10 in Vienna, Austria for 6th Annual Summit 4CIRTEC Medical Systems to support new UT Dallas-led Initiative to deliver biomedical technologies from laboratory bench to bedside more efficiently 2NCSA Scales CD-adapco’s STAR-CCM+ to New World Record of 102,000 Cores on Blue Waters 2NCSA Scales CD-adapco’s STAR-CCM+ to New World Record of 102,000 Cores on Blue Waters 3
... in Clinical Chemistry- Complementary Market Positions and ... Global Opportunity, Increase Customer Choice ... Products into Olympus, Installed Chemistry Base Supports ... Accretive to Non-GAAP Earnings Per Share in ...
... 2008 Net Revenues - $30.1 million vs. $28.9 million in ... Income per Share - $0.11 vs. $0.10 in Q4 2007 ... vs. $39.2 million in Q4 2007 - a 15.1% increase2008 ... - a 34.9% increase2008 Diluted Net Income per Share of ...
... BRISBANE, Calif., Feb. 26 InterMune, Inc.,(Nasdaq: ITMN ... 12 months ended December 31, 2008. InterMune reported a ... or $0.83 per share, compared with a,net loss of $25.9 ... 2007. , Dan Welch, Chairman, Chief ...
Cached Biology Technology:Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 2Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 3Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 4Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 5Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 6ERT Reports Fourth Quarter and Full Year 2008 Results 2ERT Reports Fourth Quarter and Full Year 2008 Results 3ERT Reports Fourth Quarter and Full Year 2008 Results 4ERT Reports Fourth Quarter and Full Year 2008 Results 5ERT Reports Fourth Quarter and Full Year 2008 Results 6ERT Reports Fourth Quarter and Full Year 2008 Results 7ERT Reports Fourth Quarter and Full Year 2008 Results 8ERT Reports Fourth Quarter and Full Year 2008 Results 9ERT Reports Fourth Quarter and Full Year 2008 Results 10ERT Reports Fourth Quarter and Full Year 2008 Results 11InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 2InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 3InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 4InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 5InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 6InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 7InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 8InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 9InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 10InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 11InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 12
... rapidly and reliably amplify unknown genomic DNA ... provides hassle-free, ready-to use components, at an ... provided in each kit. The Genome Walking ... localized cloning of genomic DNA, isolating promoter ...
... kits are designed to rapidly and ... using our patented APA Technology. APAgene ... an extraordinarily competitive price. All necessary ... The Locator Kit can be used ...
A set of five peptides which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
... The FailSafe™ PCR System is the only ... first time and every time. It provides ... of the source or the property of ... FailSafe™ PCR Enzyme Mix, a unique blend ...
Biology Products: