Navigation Links
For the first time: Longevity modulated without disrupting life-sustaining function

eir larval development and reproduction were disrupted.

"So, the central question became whether we would be able to genetically manipulate one element of the pathway without disrupting its additional functions," said Dillin. "In this regard, we thought that the life extending function of this pathway would be elusive, whereas the developmental and reproductive functions would be more amenable. We were delighted to find that Smk-1 proved to be specific for the one function we thought the most elusive," he added.

Some of Dillin's earlier research had hinted at the possibility that "specificity" factors may control how and whether insulin and IGF-1 impact a target gene. Identifying those factors one by one would allow scientists to separate the different functions of insulin/IGF-1 signaling and to manipulate them individually without wreaking havoc on the organism's normal functioning.

Together with the lab of another Salk scientist, Tony Hunter, Ph.D., Dillin's team identified a protein in the worm Caenorhabditis elegans that allowed them to do just that. The protein is encoded by the Smk-1 gene. "Smk-1 is the first known gene that regulates longevity without affecting other vital functions of the insulin signaling pathway," said Wolff.

Under favorable conditions, a still unidentified molecule binds to DAF-2, the worms' equivalent of the insulin/IGF-1 receptor, which is located at the cell's surface. A cascade of signaling molecules relays the information deep into the cell till it reaches a protein called DAF-16. Known as a transcription factor, DAF-16 encodes a DNA-binding protein that turns on other genes but when DAF-2 is active, it is unable to enter the cell's nucleus to activate its target genes.

When environmental conditions turn harsh as a result of overcrowding and scarce nutrients, for example, DAF-2 signaling shuts down. No longer marooned outside the nucleus, DAF-16 crosses into the nucleus, and triggers all the
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. A genes first kiss sets off that affair known as puberty
2. Love at first smell
3. Worlds largest rainforest drying experiment completes first phase
4. PCRM develops worlds first cruelty-free insulin assay
5. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
6. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
7. DuPonts first biologically derived polymer receives global recognition
8. Anti cancer virotherapy well tolerated in first human administration, research finds
9. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
10. The first impact factor for PLoS Biology ?13.9
11. Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
Post Your Comments:
(Date:4/17/2014)... Professor Luca Razzari of the nergie Matriaux Tlcommunications ... from the John R. Evans Leaders Fund of ... acquisition of state-of-the-art biotech and nanophotonics equipment. To ... the Ministre de l,Enseignement suprieur, de la Recherche, ... These new laboratories will help us develop new ...
(Date:4/17/2014)... University engineer has developed a patented technique that ... devices. The same technique could help police during ... and Kay L. Theede chair in engineering and ... his research team have created a template-based system ... trunks. The distance detection method called stand-off ...
(Date:4/17/2014)... in German . ... money demanded of him, he can expect his premises to ... fear of the consequences is enough to make restaurant owners ... which lay their eggs in other birds, nests. If the ... take their revenge by destroying the entire nest. Consequently, it ...
Breaking Biology News(10 mins):New state-of-the-art biotech and nanotech equipment for INRS 2Patented research remotely detects nitrogen-rich explosives 2Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3
... A new minute freshwater snail species belonging to the genus ... Athens (Canella Radea) in a spring covered by snow on ... access journal Zookeys . The ... shell, grey-black pigmented soft body and a black penis with a ...
... investigating a murder, every clue helps. New research from North ... blow flies survive when buried underground during their development. ... long a body may have been left above ground before ... one grave to another. "Blow flies are probably the ...
... R.I. [Brown University] Doctors agree that vitamin D promotes ... cancer, cardiovascular disease and other causes of death has been ... by the Institute of Medicine, a new study finds that ... women after controlling for key health factors such as abdominal ...
Cached Biology News:Digging up clues: Research on buried blow flies to help crime scene investigators 2Vitamin D study suggests no mortality benefit for older women 2
(Date:1/15/2014)... NIAGARA FALLS, N.Y., Jan. 15, 2014   Niagara ... has been selected by Buffalo BioBlower Technologies LLC ("B3") ... its SBIR Phase 2 award from the Army Corps ... purification system that kills all biological contaminants and destroys ...
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
(Date:1/15/2014)... 2014 Two champions of science, technology, ... of an annual competition for middle and high school ... innovative STEM study. The competition presents students with real-world ... Engineering Aptitude, Mathematics, and Sciences is a program ...
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... research solutions, today announced that Lupin Limited, one of ... Freeslate’s CM Protégé PharmD System for high ... Mumbai, India, is focused on a wide range of ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... to implement a Web project, there is no shortage of vendors ... the best choice? , ,Selecting the right Web developer, Web designer, ... can be a challenge. You want to be sure that the ... and marketing needs in the process, and maintains an adequate level ...
... State Senator Ted Kanavas remains optimistic that his ... pass the legislature yet this year. , ... Representative Jeff Fitzgerald, R-Horicon, would require companies that ... notify those people when that data is obtained ...
... Wisconsin System and partners around the state have been awarded ... to create health-care training projects to help resolve the nationwide ... Fast-Track (SWIFT) Nurse Educators program, which started as a task ... reduce the training period for nurses by anywhere from 18 ...
Cached Biology Technology:The best and the rest: rating Web developers 2The best and the rest: rating Web developers 3The best and the rest: rating Web developers 4Kanavas thinks personal ID theft bill will pass this year 2
Porcine Aortic Smooth Muscle Cells (PAOSMC) (>500,000 cells)...
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
Porcine Aortic Endothelial Cells (PAOEC) (>500,000 cells)...
alpha-N-Catenin Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Biology Products: