Navigation Links
Flu shot effective against drifted influenza, nasal spray vaccine less so

During a year in which the circulating strains of influenza showed genetic differences from the strains in vaccines, the traditional killed-virus flu shot was found to be effective in preventing influenza in healthy adults. The live attenuated-virus nasal spray vaccine also prevented illnesses but was less effective.

Both outcomes were determined by laboratory confirmation of flu infection, a University of Michigan study found.

Earlier studies had suggested that the nasal spray, sold by MedImmune as FluMist, might offer better protection against drifted viruses that had genetically changed between vaccine formulation and annual influenza activity. The nasal spray, which is based on a live but weakened virus, was 86 percent protective in one study conducted in children during a major drift year. However, FluMist had not previously been studied head-to-head against the shot in adults with laboratory confirmation.

The killed-virus flu shot is usually billed as 70 to 90 percent effective against circulating strains that are well matched to vaccine strains. During the 2004-2005 flu season, a University of Michigan team found that the killed-virus flu shot was 75 percent effective against a moderately-drifted type A virus and two types of B virus. The standard formulation of both the flu shot and the nasal spray vaccine includes two types of A influenza and one B, but in the 2004-05 season, there were two B strains circulating and one type A.

"On the other hand, FluMist was 48 percent effective. These results may only apply to the 2004-05 flu season," said Dr. Arnold S. Monto, professor of epidemiology. "In other years the results may be different. We need a more specific understanding of which viral changes matter and which don't. There are many things about vaccine protectiveness that we still don't completely understand."

"It may be that the difference in effectiveness between the shot and the spray can be attributed to poore
'"/>

Source:University of Michigan


Page: 1 2 3

Related biology news :

1. Combination therapy boosts effectiveness of telomere-directed cancer cell death
2. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
3. Boosting HIV screening can increase survival and is cost effective
4. Live vaccines more effective against horse herpes virus
5. Man-made wetlands effectiveness similar to natural marsh
6. Wake Forest scientists find new combination vaccine effective against plague
7. UCLA study assesses cost-effectiveness of Hepatitis B drugs
8. New study: Sexually transmitted disease treatment can be effectively administered by sex partners
9. New vaccine protects more effectively against tuberculosis
10. Harmless virus may hold key to more effective HIV drug discovery
11. Structures of marine toxins provide insight into their effectiveness as cancer drugs

Post Your Comments:
(Date:11/24/2009)...Lupus Research Institute (LRI) today named 12 new ....6 million, recognize innovative work across a bro...or their creativity, novelty, and potential to dri...at, and cure the complex disease of systemic lupus...ed lupus researchers across the nation and include...
(Date:11/24/2009)...nger and the American College of Medical Toxicolog...n the publication of the Journal of Medical Toxic...ginning in March 2010. It was previously publishe...e Journal of Medical Toxicology , an internationa...g the science and practice of medical toxicology. ...
(Date:11/24/2009)...s release is available in Spanish . , The p...r levels of inflammatory substances in the blood, ...s shown by a research project of the University of...scientist at the School of Pharmacy. , The proje...y in relation to the control of body weight and in...
Breaking Biology News(10 mins):Lupus Research Institute announces 2009 novel research grants 2Lupus Research Institute announces 2009 novel research grants 3Springer and the American College of Medical Toxicology to work together 2It can be predicted the reaction obese patients will have to a diet 2Leukemia Lymphoma Society Pleased to Announce Partnership in Southern Ohio with Eisen Marketing Group 52076 1Leukemia Lymphoma Society Pleased to Announce Partnership in Southern Ohio with Eisen Marketing Group 52076 2Highlights of Economic and Business Growth in the Tampa Bay Region 28News Briefs 29 52073 1Highlights of Economic and Business Growth in the Tampa Bay Region 28News Briefs 29 52073 2Highlights of Economic and Business Growth in the Tampa Bay Region 28News Briefs 29 52073 3Highlights of Economic and Business Growth in the Tampa Bay Region 28News Briefs 29 52073 4Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent Safe Topical Anti Androgens 13080 1Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent Safe Topical Anti Androgens 13080 2Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent Safe Topical Anti Androgens 13080 3
...in design by a University of Houston professor wil... 2005 Nano Summit Research Conference July 28. , K...nd biochemistry at UH, will give a presentation at...technology." , Sponsored by the Nanotechnology Fo...ng forum for Texas natural science, engineering an...
...aries in time, what causes those variations, and h...ng, deforestation is a focus of study for scientis...nd development pressures in the last several decad...in the Amazon, most in the eastern and southern po...rical models and data from several disciplines to ...
...e observation that a large group of seemingly unco...s with stomach cancer. Now a multi-national resear...Institute for Cancer Research (LICR) has joined th...arget for stomach cancer therapy, according to a p...icine journal. , The paper,s first author, LICR,s ...
Other Biology News:Disease diagnosis, bioengineering covered at state nano summit 2Assessing the Amazon River's sensitivity to deforestation 2
(Date:11/25/2009)... , Ambassador to Speak at... Toronto, Canada (Vocus) November 25, 2009 -- Amb... , ,Who: ,David Appia, French Ambassador for Inter...nvest in France Agency ,To view a biography of Dav...t: ,Ambassador Appia is available to meet with pre...
(Date:11/25/2009)... ,, BEIJING,Nov.25/PRNewswire-Asia/--Sinovac...ccines,announcedtodaythatitexecuted,ajointventure(...nologyCo.,Ltd.(SinovacDalian).TheJVwillresearch,de...novacwillcontributeitsexpertise,andexperienceindev...therpartywillbringitslanduserights,manufacturingfa...
(Date:11/24/2009)... , This release is available in German . ,...ication cards: RFID tags (Radio Frequency Identifi...eryday life. They make it possible to label object...o frequency. The appropriate scanner can read and ...els can be affixed to goods under production condi...
(Date:11/24/2009)... , The New York investmen... Ltd (ASX:NEU) has agreed an AU$6.7 mil convertibl... investor. The private placement was arranged by K...nd advisor. , New York (P...k investment bank KTA Capital, LLC ("KTA Capi...
Breaking Biology Technology:French Ambassador for International Investment to Visit Toronto December 11 2Sinovac Establishes Joint Venture to Expand Human-Use Vaccine Development and Manufacturing Capabilities 2Sinovac Establishes Joint Venture to Expand Human-Use Vaccine Development and Manufacturing Capabilities 3Intelligence inside metal components 2KTA Capital Arranges an AU$6.7 Million Private Placement by Neuren Pharmaceuticals 2
...rvard Medical School, is a prominent expert on RNA... of the Institut Pasteur, Paris, France, is fore...BRIDGE, Mass., Oct. 6 Cequent Pharmaceuticals, a,...liver RNAi-based,treatments to prevent and treat h...ientists in RNA Interference (RNAi) and gene deliv...
...ions and workshops to highlight two day event, NE...symposium will bring the stem cell research commun...lding on the successful StemCONN 07, which brought...artford last year, StemCONN 09 will,showcase the l...ential,medical applications. Included in the two d...
...Oct. 6 Epeius Biotechnologies,Corporation today a...,describing recent technological advances in medic...itled "Targeting metastatic cancer from the,inside...rs enables,personalized cancer vaccination in situ...national Journal of Oncology (IJO). The paper desc...
Other Biology Technology:Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D. 2Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D. 3Connecticut's Universities Team Up to Host 2009 Stem Cell Symposium 2Targeting Metastatic Cancer From the Inside: Epeius Biotech Reveals a New Generation of Tools for Medical Gene Delivery 2
Corning Spin-X Centrifuge Tube Filters from Sigma-Aldrich
HybriWell Sealing System from Grace Bio Labs
...le, press-to-seal gasket and cover slip enclosures...or hybridizing and imaging thick or free floating ...eter. Build up to three chambers per slide. Minimi...aking even when submerged. RNase-free, ready to us...
... formulation , High antibody-binding surface impr...ations , Plates are certified for performance ...ight-well strips fit snugly in the plate frame, vi... if turned upside down , Strip guides help to av...
Biology Products: