Navigation Links
Flies on speed offer insight into the roles of dopamine in sleep and arousal

Methamphetamine, the drug of choice for long-distance truckers and college students pulling all-nighters, appears to do a similar trick for fruit flies, too. This finding is one of several in a new study that demonstrates a critical role for the neurotransmitter dopamine in the modulation of sleep, wake, and arousal states.

The work is reported by Dr. Ralph Greenspan and colleagues at The Neurosciences Institute in San Diego.

The researchers found that long, sleepless nights, heightened locomotor activity, frenetic brain activity, and frenzied (but ultimately ineffective) courtship behavior are all characteristics of fruit flies on methamphetamine, the effects of which are known to act through the neurotransmitter dopamine. In the new work, the researchers showed that genetically engineered flies whose dopamine cells could be turned off experimentally, or flies that have received dopamine inhibitors, show converse behavioral effects to those seen in normal flies that have ingested methamphetamine. The results suggest that the right balance of dopamine is necessary for proper brain functioning, as has been seen in human studies of attention and distraction. Dopamine has been implicated in numerous aspects of brain function in humans and other animals, and many of these brain functions involve the modulation of neuronal activity and the ability to assign proper saliency (or relevance) to sensory stimuli.


'"/>

Source:Cell Press


Page: 1

Related biology news :

1. Flies dont buzz about aimlessly!
2. Sleepless for science: Flies show link between sleep, immune system in Stanford study
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. Influenza vaccine uses insect cells to speed development
5. Rabies spread speeds up
6. New technique may speed DNA analysis
7. Scientists discover gene that controls speed of tuberculosis development
8. Stressed cells spark DNA repair missteps and speed evolution
9. UW scientists report a new method to speed bird flu vaccine production
10. Agreement will speed research on microbicides for women
11. Treating populations infected with HIV and latent TB could speed the emergence of drug-resistant TB
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2017)... LAS VEGAS , Jan. 4, 2017  For the thousands of ... , a global leader in connected health and biometric measurement devices and ... pressure monitors. On display in A&D Medical,s special CES ... monitors represent the ongoing expansion of the company,s WellnessConnected product ... ...
(Date:12/22/2016)... 2016 SuperCom (NASDAQ:   ... the e-Government, Public Safety, HealthCare, and Finance sectors announced today that ... selected to implement and deploy a community-based supportive services program to ... , further expanding its presence in the state. ... This new program, which is ...
(Date:12/16/2016)... 16, 2016   IdentyTechSolutions America LLC , ... and solutions and a cutting-edge manufacturer of software ... is offering seamless, integrated solutions that comprise IDT ... The solutions provide IdentyTech,s customers with combined physical ... from crime and theft. "We are ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... Mass. , Jan. 18, 2017   Boston ... novel compounds designed to target cancer stemness pathways, will ... investigational compound, napabucasin, at the 2017 ASCO Gastrointestinal Cancers ... Francisco . Napabucasin is an ... by targeting STAT3. i Cancer stem cells (CSCs) ...
(Date:1/18/2017)... , Jan. 18, 2017   Parent Project Muscular ... to end Duchenne muscular dystrophy (Duchenne) , today ... New Jersey Institute of Technology (NJIT) and Talem Technologies ... of robotic technology to assist people living with ... NJIT,s technology – an embedded computer, software, a force ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... that Dr. Dante Leven successfully implanted SpineFrontier’s A-CIFT™ Solofuse-P™. The operation took place ... in Valley Stream, NY. The procedure was an anterior cervical discectomy and fusion ...
(Date:1/18/2017)... ... 2017 , ... Announced in December 2016, RoosterBio is now ... of Commerce Penny Pritzker has announced the award of a new National Institute ... the award of a new Advanced Regenerative Manufacturing Institute (ARMI). These are the ...
Breaking Biology Technology: