Navigation Links
Flies on speed offer insight into the roles of dopamine in sleep and arousal

Methamphetamine, the drug of choice for long-distance truckers and college students pulling all-nighters, appears to do a similar trick for fruit flies, too. This finding is one of several in a new study that demonstrates a critical role for the neurotransmitter dopamine in the modulation of sleep, wake, and arousal states.

The work is reported by Dr. Ralph Greenspan and colleagues at The Neurosciences Institute in San Diego.

The researchers found that long, sleepless nights, heightened locomotor activity, frenetic brain activity, and frenzied (but ultimately ineffective) courtship behavior are all characteristics of fruit flies on methamphetamine, the effects of which are known to act through the neurotransmitter dopamine. In the new work, the researchers showed that genetically engineered flies whose dopamine cells could be turned off experimentally, or flies that have received dopamine inhibitors, show converse behavioral effects to those seen in normal flies that have ingested methamphetamine. The results suggest that the right balance of dopamine is necessary for proper brain functioning, as has been seen in human studies of attention and distraction. Dopamine has been implicated in numerous aspects of brain function in humans and other animals, and many of these brain functions involve the modulation of neuronal activity and the ability to assign proper saliency (or relevance) to sensory stimuli.


'"/>

Source:Cell Press


Page: 1

Related biology news :

1. Flies dont buzz about aimlessly!
2. Sleepless for science: Flies show link between sleep, immune system in Stanford study
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. Influenza vaccine uses insect cells to speed development
5. Rabies spread speeds up
6. New technique may speed DNA analysis
7. Scientists discover gene that controls speed of tuberculosis development
8. Stressed cells spark DNA repair missteps and speed evolution
9. UW scientists report a new method to speed bird flu vaccine production
10. Agreement will speed research on microbicides for women
11. Treating populations infected with HIV and latent TB could speed the emergence of drug-resistant TB
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/31/2016)... -- Genomics firm Nabsys has completed a financial  restructuring under ... M.D., who returned to the company in October 2015. ... including Chief Technology Officer, John Oliver , Ph.D., ... Vice President of Software and Informatics, Michael Kaiser ... Bready served as CEO of Nabsys from 2005-2014 and ...
(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge (BDC), ... new ways to harness living systems and biotechnology, announced ... (MoMA) in New York City . ... participating students, showcased projects at MoMA,s Celeste Bartos Theater ... Antonelli , MoMA,s senior curator of architecture and design, ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... on quality, regulatory and technical consulting, provides a free webinar on ... on July 13, 2016 at 12pm CT at no charge. , Incomplete investigations ...
Breaking Biology Technology: