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Flick of a protein switches immune response

NFAT in combination with AP-1 and suppressed by NFAT with FOXP3.

Beyond shedding light on the immune system, the Cell paper may advance biology and medicine toward a much larger goal: how to turn single genes on or off.

"This [result] has far-reaching implications for understanding the principles of signal transduction and transcriptional networks of living cells," Chen said.

The Cell paper, which Chen describes as spanning 14 years of laboratory work, builds on a result his group published in Nature in 1998.


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Source:University of Southern California


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