Navigation Links
Flick of a protein switches immune response

A single protein can turn on and off a key component of the immune system by changing partners in an elegant genomic dance, said researchers at the University of Southern California and Harvard Medical School.

Because autoimmune diseases ?such as arthritis, allergies and dozens of other illnesses ?begin when the body's defenses respond at the wrong time or place, the on-off mechanism for the immune system has been the subject of intense study for decades.

The USC-Harvard team studied proteins critical to immune tolerance, a term for the healthy balance between a weak immune system and an overly aggressive, indiscriminate watchdog.

Lin Chen, professor of molecular and computational biology at USC and lead co-author with Harvard's Anjana Rao, said the team's result would "open a big door for people to explain the fundamental mechanism of immune tolerance."

In the July 28 issue of Cell, the USC-Harvard group shows that the protein Nuclear Factor of Activated T cells (NFAT), in collaboration with FOXP3, an essential factor in regulatory T cells, orchestrates a genetic program critical to immune tolerance.

But the same NFAT, paired with a second family of proteins known as AP-1, instead stimulates immune response.

Chen said the finding offers the first strong evidence in favor of the 15-year-old "combinatorial control" theory of gene expression.

According to the theory, the specific expression of a gene depends on the combination of "transcription factors" acting on it. Transcription factors help to translate a gene's instructions into actual proteins. FOXP3 and NFAT are two such factors; the human body contains around 3,000.

"The work provides a structural demonstration of combinatorial control of gene expression," Chen said. "This is, in my view, the most direct demonstration that this is indeed happening in nature."

The researchers were able to identify single genes that were activated by
'"/>

Source:University of Southern California


Page: 1 2

Related biology news :

1. Flick of whiskers helps tease out brains shadow signaling system
2. New, automated tool successfully classifies and relates proteins in unprecedented way
3. New binding target for oncogenic viral protein
4. Controversial drug shown to act on brain protein to cut alcohol use
5. Timing is everything: First step in protein building revealed
6. UWs Rosetta software to unlock secrets of many human proteins
7. Researchers find how protein allows insects to detect and respond to pheromones
8. Signaling protein builds bigger, better bones in mice
9. Ancient olfaction protein is shared by many bugs, offering new pest control target
10. Automatic extraction of gene/protein biological functions from biomedical text
11. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Flick protein switches immune response

(Date:8/22/2014)... antioxidants and can reduce free radical damage. ... oxidative stress? Jianbo Zhao and co-workers from ... University, China discovered that green tea polyphenol ... apoptosis, indicating green tea polyphenols play a ... oxidative stress. The relevant study has been ...
(Date:8/22/2014)... birds and the bees. But that old expression ... The fertilization process for flowering plants is particularly ... and female reproductive cells. New research from an ... and including Carnegie,s Wolf Frommer, David Ehrhardt, and ... process that guides flowering plant fertilization. It is ...
(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
Breaking Biology News(10 mins):Calcium and reproduction go together 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4
... India (January 9, 2011) - While age-related vision loss ... 17 million patients today to 55 million by the year ... vision even restored using molecular medicine. ... speaking at the 10th annual meeting and International Conference on ...
... to conserving the UK,s largest and most spectacular terrestrial beetle ... London and the University of York have developed a series ... ginger lures to trap adult beetles and tiny microphones to ... Conservation efforts have been hampered until now because ecologists lacked ...
... RIVERSIDE, Calif. The first commercial crop of a ... of California, Riverside will be harvested beginning later this ... of an induced mutation of W. Murcott mandarin. Originally ... color, easy-peel rind and tangy-sweet flavor traits shared ...
Cached Biology News:Molecular medicine could avert predicted catastrophic vision loss in the aged 2Molecular medicine could avert predicted catastrophic vision loss in the aged 3Ginger is key ingredient in recipe for conserving stag beetles 2Tango mandarins to appear this month in produce aisles 2Tango mandarins to appear this month in produce aisles 3
(Date:8/22/2014)... The first direct observations of how facets form ... towards more sophisticated and effective nanocrystal design and ... describing crystal growth breaks down at the nanoscale. ... (DOE),s Lawrence Berkeley National Laboratory (Berkeley Lab) used ... high-resolution, fast-detection camera to capture the physical ...
(Date:8/22/2014)... 22, 2014 Research and Markets ... China Gel Permeation Chromatography (GPC) Industry Report 2014" ... and China Gel Permeation Chromatography (GPC) Industry Report is ... of the global gel permeation chromatography industry with a ... a basic overview of the industry including definitions, classifications, ...
(Date:8/22/2014)... August 22, 2014 The identification ... organisms can be accelerated by exome sequencing. Built ... technologies, the custom SeqCap EZ Developer system has ... Mr. Watson will additionally present how he achieved ... available human and mouse exome kits. With over ...
(Date:8/21/2014)... Institute for Molecular Medicine Finland (FIMM), University of ... novel "man and machine" decision support system for ... described in PLOS One scientific journal ... computer vision algorithms similar to those used in ... the diagnostically most relevant areas. Tablet computers can ...
Breaking Biology Technology:Shaping the future of nanocrystals 2Shaping the future of nanocrystals 3Shaping the future of nanocrystals 4Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2A novel 'man and machine' decision support system makes malaria diagnostics more effective 2
... -- Further analysis of phase 2 breast cancer data show ... of new metastases, -- Results from 169 patients ... apparent lack of immunogenicity ... Inc.,(Nasdaq: MITI ), a biopharmaceutical company focusing on the ...
... of CD44 found in breast colon, and ... ... (TSX:,ARI), a biotechnology company discovering and developing the next wave of,antibody ... Stem Cell program has successfully completed its first,toxicology study and has ...
... at Transcatheter Cardiovascular Therapeutics 2007 Scientific ... ... Israel and WASHINGTON DC, October 23 /PRNewswire-FirstCall/,-- TopSpin Medical (TASE: ... study of the TopSpin Intravascular,Magnetic Resonance Imaging System During Coronary ...
Cached Biology Technology:Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings 2Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings 3Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings 4Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings 5ARIUS announces cancer stem cell antibody program successfully completes first toxicology study 2ARIUS announces cancer stem cell antibody program successfully completes first toxicology study 3Clinical Study Findings Show Safety and Procedure Success for TopSpin IntraVascular MRI Catheter for the Coronary Arteries 2Clinical Study Findings Show Safety and Procedure Success for TopSpin IntraVascular MRI Catheter for the Coronary Arteries 3
... Time-resolved microscopy is the ultimate tool ... subcellular structures. Its applications previously have been ... because microscope optics do not transmit in ... leader in fluorescence spectroscopy, introduces a filter-based ...
... using many of the automation concepts from ... requirements are similar to those for HTS: ... 24 or 48 wells with well volumes ... the number of wells has increased to ...
... Dermal Fibroblasts (Mouse/BalbC) and media. This cell ... and is guaranteed to provide an additional ... date supplied, when used with the recommended ... 18.5 ,Applications: ,Cultivation: Plate at ...
... Sphingobeads are designed for protein ... characterize sphingosine binding proteins. An ... mL of agarose beads with ... through the terminus of the ...
Biology Products: