Navigation Links
Flesh-eating bacteria escape body's safety net

Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that so-called flesh-eating "Strep" bacteria use a specific enzyme to break free of the body's immune system, a finding which could potentially lead to new treatments for serious infections in human patients.

The research, reported in the February 21, 2006 issue of the journal Current Biology, focuses on the major human pathogen group A Streptococcus. Among the most important of all bacterial pathogens, strep is responsible for a wide range of diseases ?from simple throat and skin infections to life-threatening conditions such as necrotizing fasciitis ("flesh-eating disease") and toxic shock syndrome.

"These findings suggest a novel approach to treating serious Strep infections, such as flesh-eating disease, by assisting our body's own defense system," said senior author Victor Nizet, M.D., UCSD associate professor of pediatrics and an infectious diseases physician at Children's Hospital, San Diego.

The UCSD investigators examined the interaction of Strep bacteria with neutrophils, specialized white blood cells that play a front line role in human's immune defense against pathogenic microbes. Recent research by European investigators had shown that neutrophils are particularly effective defenders because they release "nets" composed of DNA and toxic compounds to entrap and kill invading bacteria. In the current study, the UCSD scientists proved that disease-causing Strep release an enzyme that degrades these DNA nets, thereby allowing the organism to escape the neutrophil net and spread in body tissues.

The UCSD team used a molecular genetic approach for their studies, knocking out the gene encoding the DNA-degrading enzyme from a pathogenic Strep strain that was originally isolated from a patient suffering from necrotizing fasciitis.

"Deprived of this single enzyme, the mutant Strep strain was easily killed by human neutrophils"
'"/>

Source:University of California - San Diego


Page: 1 2

Related biology news :

1. Anti-bacterial additive widespread in U.S. waterways
2. A bacterial genome reveals new targets to combat infectious disease
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Scientists discover that host cell lipids facilitate bacterial movement
5. Family trees of ancient bacteria reveal evolutionary moves
6. Drug-resistant bacteria on poultry products differ by brand
7. Programmable cells: Engineer turns bacteria into living computers
8. NASA links nanobacteria to kidney stones and other diseases
9. Substance protects resilient staph bacteria
10. Physiological effects of reduced gravity on bacteria
11. Anammox bacteria produce nitrogen gas in oceans snackbar
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Flesh eating bacteria escape body safety net

(Date:10/19/2014)... access in India over the last 30 years ... emissions growth during that time, according to a ... Climate Change ., "Energy access is fundamental to ... life, including education, communication, and health," says IIASA ... While increased energy access is widely agreed to ...
(Date:10/17/2014)... – Accurate knowledge regarding Ebola is critical and pertinent ... of hazardous global outbreak and epidemic. The Journal, ... a special issue, Ebola Virus and Public Health, to ... knowledge in this critical societal moment. , On ... Ebola for Clinicians . The primer was prepared by ...
(Date:10/16/2014)... on the human body. Battles are won, lost ... cancer, this stalemate—known as tumor dormancy—can last up ... phenomena that is poorly understood. , A ... Salvatore Torquato, a Professor of Chemistry at Princeton ... dormancy and the switch to a malignant state. ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Modeling tumor dormancy 2
... October, 2010 Elsevier Properties SA today congratulated ... (Sandy) Lawson, for receiving the 2011 Herman Skolnik ... Division of Chemical Information (CINF), the award recognizes ... and practice of chemical information science and related ...
... of cell and developmental biology, has been awarded one ... Awards, one of the NIH,s most prestigious grants. ... address a significant medical science challenge: identifying the full ... and disease processes such as cancer. Major, a ...
... Rensselaer Polytechnic Institute professors have been named 2010 fellows ... Center for Biotechnology and Interdisciplinary Studies (CBIS) and the ... Engineering Jonathan Dordick and Professor Emeritus of Chemistry Leonard ... "outstanding achievements in and contributions to the science, the ...
Cached Biology News:Professor Dr. Alexander (Sandy) Lawson is awarded the 2011 Herman Skolnik Award 2UNC scientist receives NIH director's New Innovator Award 2Rensselaer professors Dordick and Interrante named ACS Fellows 2
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market by ... Systems, Table-top Counters) by End-user (Inpatient Pharmacy Automation, ... to 2019” analyzes and studies the major market ... Asia-Pacific, and the Rest of the World (RoW). ... spread through 300 pages and in-depth TOC on ...
(Date:10/20/2014)... , A major pan-European survey into the ... care has revealed changing trends in many important GI ... of healthcare services across the continent. The results of ... (UEG), have been announced today and led to calls ... of GI disorders across Europe ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy ... of donor stem cells for dogs with osteoarthritis. Dr. ... has performed clinical stem cell therapy for 7 years. ... if a single injection of donor stem cells into ... pain and inflammation in the treated joints. , ...
(Date:10/19/2014)... The Asian Automatic patient billing report ... and forecast of revenue. The Automatic patient billing market ... million by 2018, at a developing CAGR of 7.2% ... of the Asian Automatic patient billing market, to get ... provides a glimpse of the segmentation of this market ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... Turn Massive Amounts of Data into Gems of Knowledge ... , Abstract , This paper discusses key ... the degree (volume) and complexity of life science data ... to data integration that enables rapid ‘harvesting’ and analysis ...
... Rönn 1 , M. Landström 2 , A. Edman-Örlefors 1 , and S. ... 1 GE Healthcare, Uppsala, Sweden , ... , , ... levels, with linearity over 3.6 orders of magnitude. Two antigens can be detected ...
... , Introduction , ... is a major requirement in drug development and a key ... coupled receptors (GPCRs) (1). , <P ,>It ... potential therapeutic value requiring identification of natural or artificial ligands. ...
Cached Biology Technology:Exploiting the Life Science Data Explosion to Speed New Drug Discovery 2Exploiting the Life Science Data Explosion to Speed New Drug Discovery 3Exploiting the Life Science Data Explosion to Speed New Drug Discovery 4Exploiting the Life Science Data Explosion to Speed New Drug Discovery 5Exploiting the Life Science Data Explosion to Speed New Drug Discovery 6Exploiting the Life Science Data Explosion to Speed New Drug Discovery 7Exploiting the Life Science Data Explosion to Speed New Drug Discovery 8Exploiting the Life Science Data Explosion to Speed New Drug Discovery 9Exploiting the Life Science Data Explosion to Speed New Drug Discovery 10Exploiting the Life Science Data Explosion to Speed New Drug Discovery 11Exploiting the Life Science Data Explosion to Speed New Drug Discovery 12Exploiting the Life Science Data Explosion to Speed New Drug Discovery 13Exploiting the Life Science Data Explosion to Speed New Drug Discovery 14Exploiting the Life Science Data Explosion to Speed New Drug Discovery 15Exploiting the Life Science Data Explosion to Speed New Drug Discovery 16Exploiting the Life Science Data Explosion to Speed New Drug Discovery 17Detection and quantitation of low-abundant proteins with ECL Plex fluorescent Western blotting 2Detection and quantitation of low-abundant proteins with ECL Plex fluorescent Western blotting 3Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 2Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 3Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 4Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 5Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 6
This kit only detects beta-galactosidase activity at pH 6 in cultured cells andtissue sections. Beta-galactosidase activity at pH 6 ispresent only in senescent cells, and is not found inpresenescent...
2,4,6, Trinitrophenyl hapten is conjugated to lipopolysaccharide (LPS)....
... need to make your strain of cells competent ... for preparing competent cells are comprehensive and customized ... service offers: High transformation efficiencies ... Quality control performance testing Great ...
... petroleum-based applications. Multiple solvents can be used, such as water, benzene, formamide, nitrobenzene, cyclohexane, 1,4-dioxane, ... * Range: ... ... ...
Biology Products: