Navigation Links
Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool

The largest-ever experimental analysis of duplicated genes provides insight into mechanisms of evolution

When Mother Nature creates an identical copy of a gene in an organism's genome, the duplicated copy is usually deleted, inactivated, or otherwise rendered nonfunctional in order to prevent genetic redundancy and to preserve biological homeostasis. In some cases, however, gene duplicates are maintained in a functional state. Until now, the biological and evolutionary forces behind the maintenance of these duplicates as functional components of the genome have remained unclear.

To determine the basis for the persistence of functional gene duplicates in the genome, three scientists at the Institute of Molecular Systems Biology at the Swiss Federal Institute of Technology in Zurich have collaborated on the largest systematic analysis of duplicated gene function to date. Using an integrative combination of computational and experimental approaches, they classified duplicate pairs of genes involved in yeast metabolism into four functional categories: (1) back-up, where a duplicate gene copy has acquired the ability to compensate in the absence of the other copy, (2) subfunctionalization, where a duplicate copy has evolved a completely new, non-overlapping function, (3) regulation, where the differential regulation of duplicates fine-tunes pathway usage, and (4) gene dosage, where the increased expression provided by the duplicate gene copy augments production of the corresponding protein.

Their results, which appear in the October issue of the journal Genome Research, indicate that no single role prevails but that all four of the mechanisms play a substantial role in maintaining duplicate genes in the genome.

"Our results contradict other recent publications that have focused on a single selective pressure as the basis for the retention of gene duplicates," explains Dr. Uwe Sauer, principal investigator on the project and Pro fessor at the Institute of Molecular Systems Biology at the Swiss Federal Institute of Technology in Zurich. "We show that, at least for yeast metabolism, the persistence of the duplicated fraction of the genome can be better explained with an array of different, often overlapping functional roles."

Yeast metabolism provides an ideal model for investigating the functional basis for gene duplication because a large proportion of genes involved in this biological process have been duplicated. Of the 672 genes involved in yeast metabolism, 295 genes can be classified into 105 families of duplicates. To put this into perspective, the yeast genome has an estimated total of 6,000 genes, 1,500 of which are considered to be duplicates. An ancient whole-genome duplication event is thought to be responsible for the formation of many of these duplicate copies.

Sauer's group demonstrated that of the 105 families of duplicated gene families involved in yeast metabolism, 34 demonstrated back-up function, 19 were involved in increased gene dosage, 18 exhibited regulatory functions, and 18 had evolved new, more specialized functions. Therefore, each of these mechanisms plays a substantial and important role in the maintenance of functional duplicates in the gene pool.


'"/>

Source:Cold Spring Harbor Laboratory


Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly Discovered Compound Blocks Known Cancer-Causing Protein
4. Newly discovered pathway might help in design of cancer drugs
5. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
6. Newly discovered protein an important tool for sleeping sickness research
7. Newly discovered genetic disease sheds light on bodys water balance
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
11. Newly identified mechanism helps explain why people of African descent are more vulnerable to TB
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2018)... ... 2018 , ... Nurse practitioners and physician ... healthcare careers in the past year, according to the second annual survey of ... with a wide variety of career- and employment-related resources including physician/candidate database, job ...
(Date:8/2/2018)... ... August 02, 2018 , ... ... our Austin office, has been named Practice Group Chair for the Pharmaceuticals and ... help continue growing Dickinson Wright’s healthcare and life sciences initiatives, and appreciate the ...
(Date:8/1/2018)... ... July 31, 2018 , ... Prominent ... Global Conference , Awards honor late founder of Wisdom National Brands® makers of ... presented prestigious stevia awards to a renowned German professor and a prominent Belgian ...
Breaking Biology News(10 mins):
(Date:8/11/2018)... ... ... Researchers performing pressurized NMR or EPR experiments face a danger of the tube ... & EPR by Wilmad-LabGlass – SP Scienceware shields researchers from flying debris and ... significantly grown in popularity over the last several years. As a result, the risk ...
(Date:8/9/2018)... ... 2018 , ... Since their establishment in 2012, ambitions have been high at ... its’ size from last year, the company is thrilled to announce the release of ... crowds at a private product launch event during the annual Protein Society Symposium in ...
(Date:8/7/2018)... ... August 06, 2018 , ... ... diagnostics companies, announces the placement of Dr. Paul Harney as President, North America ... America growth strategy and enhancing client satisfaction. He was also named to Prescient’s ...
(Date:7/31/2018)... ... July 31, 2018 , ... ZeptoMetrix™ ... quality controls to its expanding CE/IVD product inventory. , “We are pleased today ... QC offerings. ZeptoMetrix remains entirely committed to fully support and provide our diagnostics ...
Breaking Biology Technology: