( Researchers at the University of Minnes...)Fish and chips: A fast track to understanding blood development

Every day, blood stem cells divide and differentiate to generate approximately 200 billion new blood cells in the bone marrow of adults. To maintain their numbers over time, blood stem cells also can divide and give rise to new blood stem cells through a process called self-renewal. What was not fully understood is which genes control the self-renewal and differentiation processes, and how these genes could be used to influence, or regulate, these processes.

The research will be published in the July issue of the journal of Public Library of Science Biology.

"If we can find a way to coax blood stem cells to self-renew and thus expand in the laboratory, doctors will have more options in treating diseases such as blood disorders, leukemias, and lymphomas," said Catherine Verfaillie, M.D., director of the University's Stem Cell Institute.

For example, researchers at the University already perform umbilical cord blood transplants to treat disease. But there are often not enough blood stem cells harvested from a single collection of umbilical cord blood to effectively treat adults and older children. This research provides insight into understanding how to stimulate blood stem cells to multiply so that scientists could generate enough cells from a single umbilical cord to treat more patients.

Importantly, the researchers developed a rapid way to identify genes that regulate the functions of stem cells that give rise to blood cells. They first developed a list of 277 genes that may regulate stem cells that make blood. They then focused on a group of 61 of these genes that had unknown roles in the function of blood stem cells.

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Source:University of Minnesota