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First link of oral bacteria and preterm birth found in human

bacteria of Fusobacterium nucleatum into the blood of pregnant mice. It resulted in premature delivery for the mouse mothers and fetal death for some of their fetuses.

The pilot study is one of the first studies done on humans.

The mother, who had the presence of Bergeyella, regularly visits the dentist and showed no signs of post-partum periodontal disease--a suspected facilitating condition for bacteria to enter the bloodstream.

"If periodontal disease is not present, then this raises more questions about how the bacteria got into the amniotic fluid," said Han.

Bergeyella is one of the 700 bacteria found in the mouth. It is also one of approximately 60% of the bacteria that cannot be grown in a culture, and until now, could not be studied. Since new techniques like PCR (polymerase chain reaction) became available to track the DNA of the bacteria, it now allows for the study of those other bacteria.

Now that a link was found, Han plans to more research to answer questions that have arisen from this finding.


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Source:Case Western Reserve University


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