Navigation Links
First human study confirms that immune cells can be a primary cause of bone loss in gum disease

Researchers at The Forsyth Institute have confirmed in human gingival tissue that immune cells play a destructive role in periodontal disease. Although researchers had suspected the correlation between bone loss in periodontal (gum) disease and immune cells, this is the first time that this has been confirmed in human tissue samples. With this work, Forsyth scientists and colleagues hope to determine methods for intervening and halting bone loss and thus improving the health outcomes of the estimated 80 million Americans suffering from periodontal disease.

The study, led by Toshihisa Kawai, D.D.S., Ph.D., examined whether immune response to periodontal bacteria is protective or pathogenic in the context of gum disease. Periodontal disease is an infection of the teeth, and their supporting structures, which results in soft tissue and bone destruction, leading to tooth loss. Dr. Kawai and his colleagues had found that B cells (B and T lymphocytes are immune cells) can contribute to increased periodontal bone loss coordinating with activated T-cells. Both cell types had previously been found to manifest a host immune response to the bacteria causing bone loss in animal models, by his group.

"This research validates our hypothesis that immune cells are harmful in gum disease," said Dr. Kawai. "It's a groundbreaking discovery because it truly gives a new understanding of periodontal disease, while also raising interesting questions about immune cells. We hope this work will help us save people's teeth in the future."

Research Overview
RANKL is a protein that is a major factor in the regulation of osteoclasts (cells that destroy bone). Dr. Kawai's research examined the receptor activator of NF-kB ligand, (RANKL)-mediated osteoclastogeneis, and the pivotal role it plays in inflammatory bone resorption. The aim of this study, which will be published in the September issue of the American Journal of Pathology, was to identify the cellular s
'"/>

Source:Forsyth Institute


Page: 1 2

Related biology news :

1. Timing is everything: First step in protein building revealed
2. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
5. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
6. First real-time view of developing neurons reveals surprises, say Stanford researchers
7. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
8. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
9. First frozen egg baby born in Canada
10. Human Cells Filmed Instantly Messaging for First Time
11. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
Post Your Comments:
(Date:5/14/2015)... , May 14, 2015  Verificient ... identity verification and online remote proctoring, announced ... software-as-a-service (SaaS) company and creator of the ... of the two companies will benefit from ... Canvas. As a fully integrated ...
(Date:5/8/2015)... , May 8, 2015 Synaptics Inc. (NASDAQ: ... today announced that members of the executive management team will ... 43rd Annual Technology, Media and Telecom Conference Date: May ... in Boston, MA Cowen ... 2015 Time: 2:45pm ET Location: The New York Palace Hotel, ...
(Date:4/27/2015)... 27, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... customers the first week of May, 2015 and will ... May. Gino Pereira , Chief ... the company as Wocket® enters the consumer market. We ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Synaptics to Present at Upcoming Investor Conferences 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3
... study, scientists sampled the presence of 20 species of ... in the Adirondack Park. Calculating their occurrence at increasing ... are 36 percent more likely to occur near the ... that "human-sensitive" species were 26 percent less likely. Beyond ...
... of Nottingham has been used in a breakthrough study ... fully functioning fetal heart. The abdominal fetal ECG ... of Electrical and Electronic Engineering and on commercial sale ... company Monica Healthcare Ltd, has been used to observe ...
... to replace artificial preservatives in bread, making it tastier., ... mould fermented in sourdough bread, Michael Ganzle, professor and ... of Agricultural, Food and Nutritional Science and fellow researchers ... keep bread fresh without changing its flavour. Preservatives ...
Cached Biology News:WCS Adirondack Park study shows exurban residences impact bird communities up to 200 meters away 2WCS Adirondack Park study shows exurban residences impact bird communities up to 200 meters away 3Nottingham technology in heart development breakthrough 2Nottingham technology in heart development breakthrough 3Nottingham technology in heart development breakthrough 4
(Date:5/26/2015)... China , May 26, 2015 Tianyin ... company that specializes in the patented biopharmaceutical, modernized traditional ... (API), announced that the Company,s Annual Meeting of Shareholders ... scheduled to be held at the Company,s office located ... conference call, at 9:00 AM (local time in ...
(Date:5/26/2015)... May 26, 2015  A simple blood test developed ... to detect early Alzheimer,s disease is a step closer ... Detailed standardized guidelines that are needed before a blood ... in Alzheimer,s & Dementia . The guidelines establish ... working group that includes UNT Health Science Center. ...
(Date:5/26/2015)... Mr. Kevin Xu , President of MEBO International, on ... and President Bill Clinton for their sympathy and ... Rongxiang Xu , Kevin,s father. As a ... Dr. Xu,s commitment to the advancement of science and his ... be forgotten. As a renowned life scientist, Dr. Xu devoted ...
(Date:5/26/2015)... 26, 2015  AbbVie (NYSE: ABBV ), ... has completed the acquisition of Pharmacyclics, Inc. enhancing ... is a leader in the hematological oncology market ... treat hematological cancers, a $24 billion global market. ... AbbVie,s broad late-stage oncology pipeline, has the potential ...
Breaking Biology Technology:TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 2TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 3Guidelines bring UNT Health Science Center's blood test for Alzheimer's one step closer 2Dr. Rongxiang Xu, Beyond A Legend 2AbbVie Completes Acquisition of Pharmacyclics 2AbbVie Completes Acquisition of Pharmacyclics 3AbbVie Completes Acquisition of Pharmacyclics 4AbbVie Completes Acquisition of Pharmacyclics 5AbbVie Completes Acquisition of Pharmacyclics 6
... In its anniversary year joimax® presents numerous ... opening up the series of the big autumn congresses ... presents the now complete product range for endoscopic spinal ... new Multiuse-Set comprises instruments for endoscopic facet joint denervation ...
... -- Third ocular product partnered with ... Oxford BioMedica plc ("Oxford BioMedica" or "the Company") (LSE: ... the US Food and Drug Administration (FDA) has approved ... I/IIa clinical development of UshStat ® , a novel ...
... Sutro Biopharma, a biopharmaceutical company developing novel ... today announced that the company,s proprietary biochemical protein ... of novel protein therapeutics will be presented at ... Trevor Hallam, Ph.D., chief scientific officer of Sutro, ...
Cached Biology Technology:joimax® Launches Numerous Innovations at EuroSpine Milan From 19 To 21 October 2011 2Oxford BioMedica Announces US IND Approval for Novel Ocular Product in Usher Syndrome Type 1B 2Oxford BioMedica Announces US IND Approval for Novel Ocular Product in Usher Syndrome Type 1B 3Oxford BioMedica Announces US IND Approval for Novel Ocular Product in Usher Syndrome Type 1B 4Sutro Biopharma to Present its Biochemical Protein Synthesis Technology at BioProduction Conference 2011 in Berlin 2