Navigation Links
First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown

In a paper being presented in two American Physiological Society sessions at Experimental Biology 2006, a joint Estonian-French team demonstrated "for the first time that mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear function."

The team, which has been collaborating for over 10 years, reported that it recently "found a very interesting and unexpected phenomenon: various substances which increase mitochondrial size, also increased contractile force of cardiac fibers," or myofibrils. This effect isn't related to the mitochondrial energy production, they noted, and so a hypothesis was developed that "there might be in cardiac cells some form of mechanical signaling between organelles."

Vladimir Veksler, a former Soviet scientist who maintained his contacts with Estonian researchers after moving to Paris, said their latest research "shows that substances increasing the mitochondria can also compress the nuclear organelles, ensuring storage and treatment of genetic information."

Taken together, the results indicate that "the existence of such mechanical signaling between mitochondria and myofibrils opens a new possibility to search for drugs capable of increasing cardiac contractility," Veksler said.

*Presentations: The paper, "Direct mechanical communication between mitochondria and nucleus in cardiac cells," was chosen to be part of the "Physiological Genomics of Skeletal Muscle Adaptation in Health and Disease" Featured Topic session 199, sponsored by the APS Muscle Biology Group. Sunday April 2 at 10:30 a.m. in the Convention Center, Room 130, Moscone North. The paper will be presented at 11:15 a.m.

The research also will be presented 12:30-3 p.m. Monday April 3, APS Physiology Signaling in muscle session 486.6/board #C732. Research was performed by Allen Kaasik, Department of Pharmacology, University of Tartu, Estonia, who collaborates with Renée Ventura-Cla pier and Vladimir Veksler of INSERM, University of Paris-Sud, France.

Health

Veksler said the team has been interested for many years in mechanisms of interaction between mitochondria and other organelles. They use "skinned cardiac fibers" whose outer membranes have been chemically removed which allows them to control the intracellular medium. They believed that in the tightly packed myocyte, that "mitochondria could push and compress nearby structures like myofibrils and modulate their functional properties."

This additional evidence of intracellular mechanical signaling "may have important physiological significance," Veksler said. He noted that a "number of studies indicate a sensitivity of nuclei to external mechanical forces and suggest that nuclear deformation could influence gene expression processes. Thus, we hypothesize that drugs or intracellular conditions inducing mitochrondrial swelling could by mechanical means influence gene expression.

"More studies are needed to explore this very intriguing and promising field of knowledge," he concluded.

In the experiment, the researchers found that in an artificial medium mimicking the cytosol, 10 micro-molar of valinomycin (a potassium ionophore that induces mitochondrial matrix swelling) decreased nuclear volume by a significant 12% ± 2%. And 150 micro-molar of diazoxide (a mitochondrial ATP-sensitive potassium channel opener) reduced nuclear volume a similar amount. "However, 150 micro-molar of 5-hydrooxydecanoate (thought to be a specific inhibitor of these channels), completely blocked the effect," according to the report, leading to the conclusion that: "mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear function."

Next steps

Veksler said one idea that needs to be checked out is: If this mechanical communication changes nuclear geometry, does it also impact nuclear functio n, namely transcription?

Indeed, he said one reason for presenting their findings at Experimental Biology is to find collaborators interested in studying the relevant transcriptional processes.


'"/>

Source:American Physiological Society


Related biology news :

1. Timing is everything: First step in protein building revealed
2. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
5. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
6. First real-time view of developing neurons reveals surprises, say Stanford researchers
7. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
8. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
9. First frozen egg baby born in Canada
10. Human Cells Filmed Instantly Messaging for First Time
11. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 21, 2017 , ... Beaker, ... executive talent in the life sciences industry, today announces a strategic partnership with ... partnership takes full advantage of Beaker’s expertise in executive recruitment solutions, providing Alcami ...
(Date:6/22/2017)... ... June 22, 2017 , ... For the ... has produced a Spotlight series on “Cell Therapy Regulation” for its ... leading experts on the unique regulatory challenges of stem cell medical research. , ...
(Date:6/20/2017)... ... June 20, 2017 , ... CTNext , Connecticut’s ... has formed a Higher Education Entrepreneurship Advisory Committee to implement the recommendations of ... other high-ranking representatives from 35 higher education institutions across the state over the ...
(Date:6/20/2017)... ... , ... Do More with OHAUS , With the launch of the new ... weighing industry, to extending its expertise across the entire laboratory to a range of ... allowing for its customers to 'Do More' in the lab. , Efficiency ...
Breaking Biology Technology: