Navigation Links
First 'atlas' of key brain genes could speed research on cancer, neurological diseases

Researchers at Dana-Farber Cancer Institute have compiled the first atlas showing the locations of crucial gene regulators, or switches that determine how different parts of the brain develop ?and, in some cases, develop abnormally or malfunction. The scientists say the map will accelerate research on brain tumors and neurological diseases that result from mutations in these switch genes ?called “transcription factors.?When these genes are altered, the genes they control can go awry, causing abnormalities in the development or function of nerves and related structures. Although the gene regulators were pinpointed using mouse brains, the map applies to the human brain as well.

“This is the first systematic mapping of all of the major brain areas that shows what regulatory genes are expressed in those specific locations,?said Quifu Ma, PhD, of Dana-Farber’s Cancer Biology Department. He is senior author of a paper appearing in today’s online issue of the journal Science, along with Charles D. Stiles, PhD, also of Dana-Farber. Transcription factors are genes that control the expression, or activity, of “target?genes. These factors play a pivotal role in brain development by direction the formation of neurons and supporting cells called glia from uncommitted progenitor cells. Until now, brain transcription factors had not been systematically isolated and their locations within different parts of the brain pinned down. The map should tell scientists studying different parts of the brain, which transcription factor (TF) genes regulate the development of that brain region, and which of them to investigate as possible causes of brain tumors and other diseases. The Dana-Farber researchers already have homed in on specific TF genes regulating nerves involved in pain sensation, certain brain tumors, and speech problems caused by abnormally developing motor neurons that control muscles of the tongue. The map, known as the Mahoney Transcription Factor Atlas, has been pla
'"/>

Source:Dana-Farber Cancer Institute


Page: 1 2

Related biology news :

1. Timing is everything: First step in protein building revealed
2. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
3. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
4. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
5. First real-time view of developing neurons reveals surprises, say Stanford researchers
6. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
7. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
8. First frozen egg baby born in Canada
9. Human Cells Filmed Instantly Messaging for First Time
10. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
11. First technology to remove prions that cause vCJD from blood launched
Post Your Comments:
(Date:7/9/2015)... July 07, 2015 ... addition of the "Biometrics for Banking; Market ... report to their offering. The ... to this growth and the forecast is that ... revenue for companies involved in delivering biometric systems ...
(Date:7/9/2015)... SAN JOSE, Calif. , July 9, ... ), the leading developer of human interface ... authentication technology, the industry,s first fully hardware ... innovative Match-in-Sensor secure authentication technology is literally ... pattern storage and biometric matching within the ...
(Date:7/8/2015)... YORK , July 8, 2015  BD (Becton, ... BD & Guidepoint Mentor, a new program ... Guidepoint,s expert network services. BD is ... to improve healthcare delivery and outcomes and, with the ... entrepreneur will be able to directly engage with industry ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... , , , ... Frost & Sullivan European Border Security Product Innovation Award is ... Border Control systems. The award recognises the company,s expertise in ... value-added products to end users. , (Logo: ...
... GenWay Biotech, Inc. GenWay Clinical Laboratory, San Diego, ... College of American Pathologists (CAP), based on results ... The laboratory,s director was advised of this national ... services being provided." GenWay Biotech Inc. GenWay Clinical ...
... , This release is available in German ... limited use in predicting the future distribution of mammals. This ... of 140 indigenous European mammals. The researchers analysed data on ... the phylogenetic information of the species. Judging by the large ...
Cached Biology News:Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 2Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 3Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 4Species distribution models are of only limited value for predicting future mammal distributions 2
(Date:7/29/2015)... SAN DIEGO , July 29, 2015  Pfenex ... quarter 2015 financial results will be released on Thursday, ... 8:30 am Eastern Time, Pfenex management will host a ... a business update.  A press release outlining the financial ... to the call. Please call 1-866-376-8058 (US) ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - RepliCel Life ... stage regenerative medicine company, is pleased to announce that ... injector (RCI-02) have been locked.  Prototypes for industrial ... prepare for an application for CE mark clearance ... in 2016. (Photo: ...
(Date:7/29/2015)... ... July 29, 2015 , ... CSSi ... Silicon Valley-based CRO specializing in Clinical Trial Management. CSSi LifeSciences is specialized in ... core expertise of PRC Clinical is focused on Clinical Trial Management, Clinical Site ...
(Date:7/29/2015)... , ... July 29, 2015 , ... ... (BI) advanced cell culture products, announces the availability of BI’s line of human ... Biological Industries, these stem cell differentiation media offer a complete system for multipotency ...
Breaking Biology Technology:Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 2CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 3Rainbow Scientific, Inc. Announces Availability of Human Mesenchymal Stem Cell Differentiation Media 2Rainbow Scientific, Inc. Announces Availability of Human Mesenchymal Stem Cell Differentiation Media 3
... 29 Nektar Therapeutics (Nasdaq: NKTR ) will announce ... 2009 on Wednesday, November 4, 2009, after the close of ... will host a conference call to review the results beginning ... , The press release and a live audio-only Webcast ...
... Reportlinker.com announces that a new ... its catalogue. , Molecular ... Market , ... applications in the areas of oncology, ...
... Oct. 29 Dendreon Corporation (Nasdaq: DNDN ) today announced that management ... Merriman Investor Summit 2009, New York City, ... Credit Suisse 2009 Healthcare Conference, Phoenix, Arizona, ... Lazard Capital Markets 6th Annual Healthcare Conference, New York City, ...
Cached Biology Technology:Nektar to Announce Financial Results for the Third Quarter of 2009 on Wednesday, November 4, 2009, After Close of U.S.-Based Financial Markets 2Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 2Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 3Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 4Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 5Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 6
... MSD Security ChemStation is ... software application for data ... library searching and reporting, ... of data security, integrity, ...
... save space and organize gloves, ... other garb. They are the ... small parts used in labs, ... Open-slot design for easy cleaning. ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Soil Nematode microRNA Microarray ...
... Proteolytic degradation is critical to ... short-lived and regulatory proteins as important ... cellular metabolism, heat shock and stress ... surface receptors and ion channels, cell ...
Biology Products: