Navigation Links
Firefly protein lets researchers monitor molecule linked to cancer

Scientists have used a glowing protein from fireflies to observe the activity of a molecule that is an important target for new drugs to treat cancer, autoimmune diseases and several other disorders.

The target molecule, known as IKK (for IKappa kinase), regulates processes that can trigger dramatic changes in cellular physiology. Scientists have linked these changes to many different disorders.

"Our new system allows researchers to monitor whether drugs for these conditions are hitting this exact molecular target in cell culture and laboratory animals," says senior investigator David Piwnica-Worms, M.D., Ph.D., professor of molecular biology and pharmacology and of radiology.

Piwnica-Worms and lead author Shimon Gross, Ph.D., a postdoctoral fellow, measured light from the firefly protein, luciferase, to monitor IKK activity in tumor cells and inflamed liver cells in live mice. They also showed that the technique can greatly reduce the costs of tests that establish the best dosages for drugs that target IKK. Their results appear in the August 2005 issue of Nature Methods.

IKK stands at a pivot point in the middle of an important set of linked chain reactions known as the NF-KappaB pathway. The pathway can start at many different receptors on cell surfaces; its finish changes the activity levels of varying genes. The result, according to Piwnica-Worms, is that the potential reaction patterns in the NF-KappaB pathway form an hourglass-like shape, fanning out among many options at the start, narrowing in the middle, and again fanning out among many options at the end.

"At the waist of that hourglass is IKK," he explains. "This appears to put it in a position to be the key regulator of the pathway, and that has made it a subject of great interest both from the perspective of understanding how this pathway works and from that of developing new drugs for conditions that involve this pathway. "

Piwnica-Worms' laboratory has pr
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
(Date:4/9/2015)... Synaptics Inc. (NASDAQ: SYNA ), a leading ... will report financial results for the third quarter of ... close of market. The company will host a corresponding ... PT (5:00 p.m. ET), during which management may discuss ... live call, analysts and investors should dial 888-438-5524 (conference ...
(Date:4/2/2015)... BETHESDA, Md. , April 2, 2015 ... Salt Lake City , the American ... election of five new directors to its Board.  Members ... for the ACMG and for forming and advancing its ... the medical genetics profession. "It,s an eventful ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... in Yemen, is threatening livelihoods, in a country where rearing ... a Ministerial delegation was at the IAEA in Vienna, Austria, ... fight the deadly pest. The menacing fly lays its ... animal. The maggots then feast off the living flesh, and ...
... May 5 bioMETRX Inc., (OTC,Bulletin Board: BMRX), ... today announced that it has closed an interim,round ... of previous angel,accredited investors., "We have tremendous ... company has demonstrated to us the ability to ...
... a plant produces is closely tied to its sexual ... the evolution of such intimate relationships between plants and ... its kind and published online in the British Ecological ... recent dramatic decline in certain bumblebee species found in ...
Cached Biology News:Screw worm outbreak in Yemen 2Screw worm outbreak in Yemen 3bioMETRX, Inc. Closes Angel Round of Funding 2Ecologists tease out private lives of plants and their pollinators 2
(Date:4/27/2015)... Cleveland, Ohio (PRWEB) April 27, 2015 ... execution of an agreement with Joslin Diabetes Center ... Phase 2b study of Diasome’s novel Hepatocyte Directed ... with Type 1 diabetes. , Located in ... research, clinical care and education organization dedicated to ...
(Date:4/27/2015)... , April 27, 2015 ... information products and services, and Qatar University Research Office   ... Scopus Awards. The awards ceremony, held last week ... , was attended by more than 40 guests representing ... awards were presented by Professor Sheikha Abdulla Al-Misnad , ...
(Date:4/24/2015)... Top student social innovators from the ... universities, including UCSD and SDSU, will pitch their impact ... national and nonprofit companies for an opportunity to win ... Social Innovation Challenge 2015 . , The 2015 Social ... addressing a diverse range of issues including poverty, education, ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Leading ... milestones in its allogeneic stem-cell product development program ... properly reflect the corporate strategic direction. , “I ... (donor) adipose stem cell development program has been ... our cGMP manufacturing facility and hiring of our ...
Breaking Biology Technology:Diasome Pharmaceuticals Announces Clinical Trial Design Collaboration 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 3Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 4Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 55th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 3Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2
... Sensus Healthcare is proud to announce ... South Beach Symposium™ in Miami Beach, FL ... a comprehensive session with three non-overlapping tracks in clinical ... superficial radiotherapy (SRT) with their SRT-100™ advanced platform as ...
... YORK, Feb. 17, 2011 Reportlinker.com announces that ... its catalogue: Targeted Therapeutics- Advancement ... Drive the Market http://www.reportlinker.com/p0397055/Targeted-Therapeutics--Advancement-in-Gene-Therapy-and-Stem-Cell-Therapy-will-Drive-the-Market.html ... Therapy and Stem Cell Therapy will Drive the ...
... someday become one of the most effective weapons to stop ... of lives in Haiti since the devastating earthquake last year. ... would allow relief workers to test water sources that could ... sugar dextran is coated onto iron oxide nanoparticles and then ...
Cached Biology Technology:Sensus Healthcare Announces Its Exhibitor Attendance at the 9th Annual South Beach Symposium™ 2Reportlinker Adds Targeted Therapeutics- Advancement in Gene Therapy and Stem Cell Therapy will Drive the Market 2Reportlinker Adds Targeted Therapeutics- Advancement in Gene Therapy and Stem Cell Therapy will Drive the Market 3Special sugar, nanoparticles combine to detect cholera toxin 2Special sugar, nanoparticles combine to detect cholera toxin 3
... Product Goat polyclonal to Cholesterol Oxidase ... Reactivity / Specificity Cross-reacts with bacteria. ... Background Information Cholesterol oxidases exist as ... and are implicated in bacterial pathogenesis. In ...
Phospho-PERK (Thr980) Antibody...
Goat polyclonal to BACE1 ( Abpromise for all tested applications). entrezGeneID: 23621 SwissProtID: P56817...
Sheep polyclonal to Staphylococcus DNase ( Abpromise for all tested applications). Antigen: Full length native protein (purified)....
Biology Products: