Navigation Links
Finnish scientists discovered a new approach to treat virus-induced lymphomas

against the aggressive KSHV-induced PEL. KSHV displays two patterns of infection: latent and lytic phase. During latency, only a restricted set of viral genes is expressed. The KSHV genome encodes several homologues of cellular proteins, which engage cellular signaling pathways, govern cell proliferation and modulate apoptosis.

Majority of the PELs appear to have an intact TP53 gene suggesting that genetic alterations are not selected for during PEL tumorigenesis. The results of this study demonstrate binding of the KSHV latency associated antigen LANA to both p53 and MDM2, and that the MDM2 inhibitor Nutlin-3a disrupts the p53-MDM2-LANA complex and selectively induces massive apoptosis in PEL cells. The cytotoxic effect of Nutlin-3a was specific for the KSHV-infected cells since Nutlin-3a did not induce apoptosis in lymphoblastoid cell lines transformed with another human tumor virus, the Epstein-Barr virus, despite of their wt p53 status.

Moreover, the researchers show that Nutlin-3a has striking anti-tumor activity in vivo in a mouse xenograft model for the PEL. Nutlin-3a treatment resulted in a marked regression of all tumors in the treated animals in two weeks. These results demonstrate that p53 reactivation via Nutlin-3a is an efficient treatment for KSHV-lymphomas in mice and suggest a novel therapeutic strategy for treatment of these fatal virus-induced malignancies also in humans.
'"/>

Source:University of Helsinki


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
(Date:5/22/2013)... cell powered buses, including a team from Simon ... processes and bus membrane durability. , The team ... in the operating cycle of the bus on ... study, led by SFU graduate student Natalia MaCauley, ... Burnaby-based Ballard Power Systems and funded by Automotive ...
(Date:5/22/2013)... potential environmental and human health effects from disposal ... has led scientists to recommend stronger government policies ... (Li-ion) battery materials. That,s the conclusion of a ... Science & Technology . , Oladele A. Ogunseitan ... become mainstays for powering everything from smart phones ...
(Date:5/22/2013)... Declines in the biodiversity of pollinating insects and wild ... new study. , Researchers led by the University of ... found evidence of dramatic reductions in the diversity ... the 1950s and 1980s. , But the picture brightened ... national biodiversity losses among bees, hoverflies and wild plants. ...
Breaking Biology News(10 mins):Tests lead to doubling of fuel cell life 2Encouraging signs for bee biodiversity 2Encouraging signs for bee biodiversity 3
... One in eight women will be diagnosed with breast ... the better the chance of successful treatment and long-term ... testing by mammography remains cumbersome, costly, and in many ... stage. A team based in the Dept. of Biomedical ...
... similarity to humans, mice have long been used to learn ... shine a light on the genetic factors that cause disease ... options to protect the human population. But this process, ... more challenging by the 5% difference between the humans and ...
... shown that a dramatic sea-level rise occurred at the onset ... as the Blling warming, approximately 14,600 years ago. This event, ... rapid collapse of massive ice sheets 14,600 years ago and ... are published in the 29 March 2012 issue of the ...
Cached Biology News:Detecting breast cancer's fingerprint in a droplet of blood 2New lab mice cut search for genetic links to disease by more than a decade 2New lab mice cut search for genetic links to disease by more than a decade 3Ice sheet collapse and sea-level rise at the Boelling warming 14,600 years ago 2
(Date:5/22/2013)... 22, 2013 A recent study from ... athletes to find that those who took probiotics were able ... from the study showed that in extreme heat conditions, probiotics ... their adult acne treatment explains what this new ... may help their skin condition. , While researchers tote ...
(Date:5/22/2013)... , May 22, 2013  Moderna Therapeutics, the ... treatment modality to enable the in vivo ... John Reynders will join Moderna in early ... Reynders is a proven leader in the design ... drug development, from discovery to translation, clinical operations and ...
(Date:5/21/2013)... May 21, 2013  On May 9, 2013, ... the global business advisory firm dedicated to helping ... "Company"), announced that it has combined the healthcare ... included within the Corporate Finance/Restructuring segment with those ... form a single integrated practice whose financial results ...
(Date:5/21/2013)... 2013 Custom Learning Designs, Inc.(CLD) ... solution using Tin Can API combined with its ... is a leading developer of training content and ... worldwide. , Tin Can API is a ... and trainers more accurately measure the Return on ...
Breaking Biology Technology:Adult Acne Treatment, Probiotic Action Shares Insight on New Findings Between Probiotics and Heat Tolerance, and What It Means for Acne Sufferers 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 3FTI Consulting Releases Realigned Segment Information Reflecting Newly Combined Health Solutions Practice 2CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 2CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 3
... Insect, Plant, Bacteria, and Yeast Cells , ... , New Brunswick Scientific Co. ... 1-800-631-5417 or 1-732-287-1200; bioinfo@nbsc.com, www.nbsc.com/bi5.htm ... bottles have,become the lab standard in most fermentation and cell,culture research labs, lack of ...
... , , ... , ... for culturing cells in a BioFlo ,110 benchtop fermentor/bioreactor system. ... and control modules to,enable growth of a wide variety of cultures, ...
... Joseph Fox 1 , Joanne B. Connolly 2 , Matthew E. ... 1 Shimadzu Scientifi c Inc., Columbia, US; 2 Shimadzu Biotech/Kratos, UK ... Introduction , ... the analysis of complex peptide mixtures. These include (i) concentration and separation of ...
Cached Biology Technology:An Easy-to-Use Research Fermentor/Bioreactor 2An Easy-to-Use Research Fermentor/Bioreactor 3CHO Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 2CHO Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 3CHO Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 4LC-MALDI and MALDI-MS/MS for the Analysis of Complex Peptide Mixtures 2LC-MALDI and MALDI-MS/MS for the Analysis of Complex Peptide Mixtures 3LC-MALDI and MALDI-MS/MS for the Analysis of Complex Peptide Mixtures 4
MSE ANTI CAN. CD3:FITC/RAT ANTI CD4:RPE...
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
Edited by D. Patel (1994) Comprehensive data on gel electrophoresis of proteins, nucleic acids, nucleoproteins and carbohydrates....
Biology Products: