Navigation Links
Findings have implications for tracking disease, drugs at the molecular level

Researchers in the laboratory of Boston College Chemistry Professor John T. Fourkas have demonstrated that gold particles comparable in size to a molecule can be induced to emit light so strongly that it is readily possible to observe a single nanoparticle. Fourkas, in collaboration with postdoctoral researcher Richard Farrer and BC undergraduates Francis Butterfield and Vincent Chen, coaxed the particles into strong emission of visible light using a technique called multiphoton absorption induced luminescence (MAIL).

The most efficient gold nanoparticles could be observed at laser intensities lower than those commonly used for multiphoton imaging, in which specific tissues or cells -- cancer cells, for example -- are fluorescently-labeled using special stains that enable them to be studied.

"One of the most exciting aspects of this technique is that it paves the way for being able to observe behavior in living tissues at the single molecule level," said Fourkas. "The fluorescent molecules commonly used in multiphoton imaging give out only a limited amount of light, 'burn out' quickly under continuous observation, and are prone to blinking on and off.

"The gold particles, however, do not blink or burn out, even after hours of observation, and the brightest ones emit much more light than do molecules," he said. "We now have the ability to see single nanoparticles under conditions where people usually look at thousands or millions of stain molecules. This could allow us, for instance, to track a single molecule of a drug in a cell or other biological sample."

Other advantages of the technique are that the gold particles can be prepared easily, have very low toxicity, and can readily be attached to molecules of biological interest, said Fourkas. In addition, the laser light used to visualize the particles is at a wavelength range that causes only minimal damage to most biological tissue.

The findings will be published in the June issue of Nano Letters.


'"/>

Source:Eurekalert


Related biology news :

1. Findings advance use of adult stem cells for replacement bone
2. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
3. Science study holds implications for gene therapy and stem cell biology
4. Muscle repair: Making a good system better, faster; implications for aging, disease
5. New classification of eukaryotes has implications for AIDS treatment, agriculture and beyond
6. Inside rocks, implications for finding life on Mars
7. How mammals fuel milk production may have implications for cancer
8. Radio-tracking associated with dramatic shift in water vole sex ratio
9. UQ researcher tracking key to healing the brain
10. Concern over fast tracking of new drugs
11. How satellite tracking revealed the migratory mysteries of endangered Atlantic loggerhead turtles
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the Company") announces ... Clean Technology Fund I, LP and Clean Technology Fund ... venture capital funds which together hold approximately 59% of ... as converted basis), that they have entered into an ... in Biorem to TUS Holdings Co. Ltd. ("TUS") (en.tusholdings.com) ...
(Date:6/27/2016)... N.C. (PRWEB) , ... June 27, 2016 , ... ... commercial operations for Amgen, will join the faculty of the University of ... as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
Breaking Biology Technology: