Navigation Links
Findings have implications for tracking disease, drugs at the molecular level

Researchers in the laboratory of Boston College Chemistry Professor John T. Fourkas have demonstrated that gold particles comparable in size to a molecule can be induced to emit light so strongly that it is readily possible to observe a single nanoparticle. Fourkas, in collaboration with postdoctoral researcher Richard Farrer and BC undergraduates Francis Butterfield and Vincent Chen, coaxed the particles into strong emission of visible light using a technique called multiphoton absorption induced luminescence (MAIL).

The most efficient gold nanoparticles could be observed at laser intensities lower than those commonly used for multiphoton imaging, in which specific tissues or cells -- cancer cells, for example -- are fluorescently-labeled using special stains that enable them to be studied.

"One of the most exciting aspects of this technique is that it paves the way for being able to observe behavior in living tissues at the single molecule level," said Fourkas. "The fluorescent molecules commonly used in multiphoton imaging give out only a limited amount of light, 'burn out' quickly under continuous observation, and are prone to blinking on and off.

"The gold particles, however, do not blink or burn out, even after hours of observation, and the brightest ones emit much more light than do molecules," he said. "We now have the ability to see single nanoparticles under conditions where people usually look at thousands or millions of stain molecules. This could allow us, for instance, to track a single molecule of a drug in a cell or other biological sample."

Other advantages of the technique are that the gold particles can be prepared easily, have very low toxicity, and can readily be attached to molecules of biological interest, said Fourkas. In addition, the laser light used to visualize the particles is at a wavelength range that causes only minimal damage to most biological tissue.

The findings will be published in the June issue of Nano Letters.


'"/>

Source:Eurekalert


Related biology news :

1. Findings advance use of adult stem cells for replacement bone
2. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
3. Science study holds implications for gene therapy and stem cell biology
4. Muscle repair: Making a good system better, faster; implications for aging, disease
5. New classification of eukaryotes has implications for AIDS treatment, agriculture and beyond
6. Inside rocks, implications for finding life on Mars
7. How mammals fuel milk production may have implications for cancer
8. Radio-tracking associated with dramatic shift in water vole sex ratio
9. UQ researcher tracking key to healing the brain
10. Concern over fast tracking of new drugs
11. How satellite tracking revealed the migratory mysteries of endangered Atlantic loggerhead turtles
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/14/2016)... BioCatch ™, the global ... the appointment of Eyal Goldwerger as CEO. ... Goldwerger,s leadership appointment comes at a time of significant ... of its platform at several of the world,s largest ... unique cognitive and physiological factors, is a winner of ...
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... May 24, 2016 , ... Cell therapies for a range ... by research at Worcester Polytechnic Institute (WPI) that yielded a newly patented method ... , The novel method, developed by WPI faculty members Raymond Page, PhD, professor ...
(Date:5/23/2016)... ... 2016 , ... The need for blood donations in South Texas and across the nation is ... & Tissue Center, blood donations are on the decline. In fact, donations across the country ... percent in South Texas in the last four years alone. , There is no substitute ...
(Date:5/23/2016)... , May 23, 2016 - Leading ... 40% - Frontage Implement a Single Platform to Manage ... and Traceability Within the Bioanalytical lab Frontage Laboratories, a ... United States and China , has ... laboratory facilities. In addition to serving as the global electronic lab ...
(Date:5/20/2016)... ... 20, 2016 , ... The leading Regenerative Veterinary Medicine Company, VetStem Biopharma ... treated over 100 of their own patients with the VetStem Cell Therapy. Each of ... care for their patients. , The veterinarians are Dr Ross Rich former owner ...
Breaking Biology Technology: