Navigation Links
Findings advance use of adult stem cells for replacement bone

In a significant advance for regenerative medicine, researchers at Rice University have discovered a new way to culture adult stem cells from bone marrow such that the cells themselves produce a growth matrix that is rich in important biochemical growth factors.

The research, which appears online this week in the Proceedings of the National Academy of Sciences, is notable not just because of the science ?researchers found they could coax bone cells into produce up to 75 times more calcium ?but also because the study was conducted by an undergraduate bioengineering senior, Néha Datta.

"These results are important, not just because they hold great promise for regenerating healthy bone but also because they may be applicable to other tissues," said researcher Antonios Mikos, the John W. Cox Professor of Bioengineering and Director of Rice's Center for Excellence in Tissue Engineering. "This is also a notable personal achievement for Néha, because PNAS is one of the top scientific journals in the country and because this is the third peer-reviewed paper ?and the second first-authored paper -- that she's produced in the past year."

Tissue engineering, also known as regenerative medicine, involves harvesting stem cells from a patient's body and using them to grow new tissues that can be transplanted back into the patient without risk of rejection. Most tissue engineering approaches involve three components: the harvested adult stem cells, growth factors that cause the stem cells to differentiate into the right kind of tissue cells ?like skin or bone ?and a porous scaffold, or template, that allows the tissue to grow into the correct shape.

"Finding the right combination of growth factors is always a challenge," Mikos said. "It's not unusual for adult stem cells to progress through a half-dozen or more stages of differentiation on their way to becoming the right tissue ?and any missed cue will derail the process. In most cases, engineers have little choice but to take a trial-and-error approach to designing a growth-factor regime."

In the study, Mikos's team hit upon the idea of having the stem cells create the proper growth medium themselves. The group, which included graduate student Quynh Pham and postdoctoral research associate Upma Sharma, accomplished this by seeding discs of titanium mesh with stem cells and encouraging them to form extracellular matrix, or ECM, the boney, calcified deposit that gives bone its structural strength.

A comparison was then run on these pre-generated ECM constructs and on non-treated titanium scaffolds. The pre-treated surfaces encouraged calcification at a much faster rate. The researchers also found up to 75 times more calcium in the bone created by tissues in the pre-treated cultures.

"To me, the most important element of the research is that it may one day contribute to new treatment options for patients," said Datta, who is planning to enter medical school in the fall. "One of the reasons I want to become a surgeon is so I can help bring cutting-edge work from the laboratory into clinical practice."

Datta said one of the main reasons she chose to attend Rice was because of the tremendous opportunities available through Rice's Century Scholars Program. The program included funding for tuition as well as a chance to begin research in Mikos's lab during her freshman year.

"My research experience at Rice has been life-changing in ways I could never have imagined four years ago," Datta said. "I never anticipated I would be traveling to international conferences, for example, but from the very beginning Dr. Mikos treated me as a valuable member of his research team. He provided encouragement. He let me follow my ideas. In short, he is the perfect mentor."


'"/>

Source:Rice University


Related biology news :

1. Findings have implications for tracking disease, drugs at the molecular level
2. Research advances quest for HIV-1 vaccine
3. Inexpensive, mass-produced genes core of synthetic biology advances at UH
4. Study of genomic DNA leads to new advances in cancer diagnostics
5. Molecular models advance the fight against malaria
6. Researchers test new therapy for advanced melanoma
7. Agilent Technologies introduces advanced zebrafish, mouse microarrays for stem cell and developmental biology research
8. Major advance made on DNA structure
9. Wild grasses and man-made wheats advance research capabilities
10. Gene therapy advance treats hemophilia in mouse models
11. Scientists create digital bacteria to forge advances in biomedical research
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2016)... , Nov 15, 2016 Research and ... Global Forecast to 2021" report to their offering. ... ... USD 16.18 Billion by 2021 from USD 6.21 Billion in 2016, ... Growth of the bioinformatics market is driven by the ...
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/15/2016)... York , June 15, 2016 ... new market report titled "Gesture Recognition Market by Application ... Forecast, 2016 - 2024". According to the report, the  ... 11.60 billion in 2015 and is estimated to ... USD 48.56 billion by 2024.  Increasing ...
Breaking Biology News(10 mins):
(Date:12/5/2016)...  Renova™ Therapeutics, a biotechnology company developing gene ... chronic diseases, announced that Catherine Bovenizer , ... Officer (CFO), effective today. Ms. Bovenizer ... in financial management for a variety of public ... recently, Ms. Bovenizer was the Vice President of ...
(Date:12/5/2016)... , Dec 5, 2016 Research and ... "DNA Sequencing - Technologies, Markets and Companies" to ... , ... briefly reviews basics of human genome variations, development of sequencing ... described as well as companies developing them. Various applications of ...
(Date:12/4/2016)... , Dec. 3, 2016  In five studies ... Hematology (ASH) Annual Meeting and Exposition in ... engineering methods to improve the delivery of life-saving treatments ... new methods are designed to carry therapies directly to ... most, which could provide a substantial advantage over traditional, ...
(Date:12/2/2016)... -- The Multiple Myeloma Research Foundation (MMRF) today announced that ... —the largest and most comprehensive study driving new genomic ... presented at the 58 th American Society of ... San Diego from December 3-6. The new ... as identify pathways and targets for new drug development. ...
Breaking Biology Technology: