Navigation Links
Finding the right mix: A biomaterial blend library

From dental implants to hip replacements, biomaterials have become big business. But scientists pursuing this modern medical revolution share a basic challenge: biocompatibility. How will a biomaterial on the lab bench actually work inside the human body? Will a patient accept the new material or suffer an inflammatory response? And can that material survive in a human's complex system?

To tackle such questions, researchers at the National Institute of Standards and Technology (NIST) and the New Jersey Center for Biomaterials (NJCB) at Rutgers University have developed new methods to analyze the interactions between cells and biomaterials. Their work could lead to inexpensive techniques for building better biomaterials.

Polymers derived from the amino acid tyrosine make up a broad class of degradable biomaterials under investigation. Such materials provide a temporary scaffold for cells to grow and tissue to regenerate. In a 2006 study* presented at the national meeting of the American Chemical Society in September, the researchers analyzed how two types of model cells--immune cells known as macrophages and bone cells known as osteoblasts--responded to changes in the composition of thin films made of these tyrosine-derived polymers. In practice, many biomaterials are made from blends of polymers to achieve specific material properties. Optimizing the blend composition is often a difficult and time-consuming task. As the blends gained a higher or lower proportion of a respective material, the cells around them react by changing shape, ultimately increasing or decreasing contact with the films. In the body, such cell-material dynamics are critically important to the outcome--determining whether a biomaterial leads to inflammation or abnormal cell growth, for example.

The new study represents an innovative line of research. Working with NJCB, NIST scientists have developed a method for constructing "scaffold libraries" --collections of bioma terial scaffolds made from controlled polymer blend compositions. The library currently contains scaffolds made from blends of poly(DTE carbonate) and poly(DTO carbonate). Ultimately, Becker says, the goal is to develop rapid, inexpensive methods to predict the behavior in the body of any of thousands of possible tyrosine-derived blends.
'"/>

Source:National Institute of Standards and Technology (NIST)


Related biology news :

1. Finding Cures For Tropical Diseases: Is Open Source An Answer?
2. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
3. Findings have implications for tracking disease, drugs at the molecular level
4. Finding hidden invaders in a Hawaiian rain forest
5. New Finding May Aid Adult Stem Cell Collection
6. Finding rewrites the evolutionary history of the origin of potatoes
7. Finding the minds eye
8. Findings advance use of adult stem cells for replacement bone
9. Finding a virus is not all bad news
10. Finding a better way to make biodiesel
11. Finding paves way for better treatment of autoimmune disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... ... 11, 2020 , ... Both Roche, based in Basel, Switzerland, ... agreements with Housey Pharma’s HMI subsidiary to gain access to its core-enabling technology ... and Development spending in excess of US $10 billion. , Scientists at Housey ...
(Date:8/7/2020)... ... August 06, 2020 , ... Nine ... prestigious National STEM Scholar Program, a unique professional development program that provides advanced ... for middle school science teachers nationwide. , Created in partnership between the National ...
(Date:7/31/2020)... FREDERICK, Md. (PRWEB) , ... July 30, 2020 ... ... Business Innovation Research (SBIR) Phase II contract awarded by the Joint Science & ... goal of this project is to develop, optimize, and scale-up a highly efficient ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the solution ... history of eSource, the reasons it did not take off as quickly as people ... the industry is moving towards capturing data electronically for clinical trials and then repurposing ...
(Date:7/18/2020)... MILWAUKEE (PRWEB) , ... July 16, 2020 , ... “We ... at Third Wave Bioactives. “It’s the only technology of its kind on the market ... flavor of onions with the protective capacity of traditional cultured ingredients, creating a natural ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency ... led by Dr MA has been using the zebrafish model to investigate the ...
(Date:7/1/2020)... GREEN, Ohio (PRWEB) , ... June 29, 2020 ... ... that offers access to competitively procured purchasing contracts to its membership, recently named ... to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, ...
Breaking Biology Technology: