Navigation Links
Finding paves way for better treatment of autoimmune disease

A signaling molecule with an affinity for alcohol has yielded a rapid, inexpensive way to make large numbers of immune cells that work like beat cops keeping misguided cells from attacking the body.

The ability to easily make large numbers of these cells opens the door to improved treatment and a better understanding of autoimmune diseases such as type 1 diabetes and arthritis, Medical College of Georgia researchers say.

T cells are components of the immune system designed to attack invaders such as bacteria and viruses; regulatory T cells are a small subset that prevents the cells from also attacking body tissue.

Research published in the August issue of Nature Methods shows that, given the option, phospholipase D, which typically mixes with water, prefers alcohol. It's an apparently lethal choice for the signaling molecule that, in turn, also kills T cells that need phospholipase D to survive. Previously, it was unknown whether regulatory T cells required the molecule.

"What we have found is that if you block this enzyme, almost all T cells die after three days but the regulatory T cells can survive," says Dr. Makio Iwashima, MCG immunologist and the study's corresponding author. "After three days, we give them some food to grow and, in one week, you get about 90 percent pure regulatory cells."

The approach worked with laboratory-grade alcohol, called butanol, as well as beverage-grade ethanol.

Normally, regulatory T cells constitute about 5 percent of the T cell compartment, Dr. Iwashima says. Isolating them is doable but a long, expensive process.

When researchers gave some of the regulatory T cells to a mouse model of inflammatory bowel disease, the symptoms, including dramatic weight loss, went away. Animals showed no classic signs of inflammation, just a significant increase in regulatory cells.

MCG researchers have obtained funding from the Arthritis Foundation and the Juvenil
'"/>

Source:Medical College of Georgia


Page: 1 2

Related biology news :

1. Finding Cures For Tropical Diseases: Is Open Source An Answer?
2. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
3. Findings have implications for tracking disease, drugs at the molecular level
4. Finding hidden invaders in a Hawaiian rain forest
5. New Finding May Aid Adult Stem Cell Collection
6. Finding rewrites the evolutionary history of the origin of potatoes
7. Finding the minds eye
8. Findings advance use of adult stem cells for replacement bone
9. Finding a virus is not all bad news
10. Finding a better way to make biodiesel
11. Finding the right mix: A biomaterial blend library
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Finding paves way for better treatment autoimmune disease

(Date:11/21/2014)... DALLAS , November 18, 2014 ... Security Systems Market by Systems (Video, RFID, Access Control, ... (SEZ, Factories, Hotels, Banks, Government), Component Service Geography - ... Security Systems Market is projected to be around $25 ... Billion by 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... REDMOND, Wash. , Nov. 20, 2014 ... access for the Internet of Things (IoT), today announced ... position of chief operating officer. Previously a strategic advisor ... marketing, finance, and operations. Mr. Traynor is based out ... . He reports to Chris Muench , ...
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... have maintained their roles for millions of years and ... widely from territorial fighting to setting up social hierarchies, ... and Grand Valley State University. , If these "mean ... different contexts, then perhaps model organisms -- such as ...
... of chemists and engineers at Penn State University have ... them with ultrasonic waves and steered them magnetically. It,s ... which are rocket-shaped metal particles, move around inside the ... "As these nanomotors move around and bump into structures ...
... devices that electrically stimulate the auditory nerve have ... of people worldwide who otherwise would be totally deaf. ... disk-shaped transmitter about an inch in diameter be affixed ... a joint microphone and power source that looks like ...
Cached Biology News:Wasps use ancient aggression genes to create social groups 2Wasps use ancient aggression genes to create social groups 3Nanomotors are controlled, for the first time, inside living cells 2Cochlear implants -- with no exterior hardware 2Cochlear implants -- with no exterior hardware 3
(Date:12/17/2014)... 16, 2014 The Activated Carbon ... which is why IBISWorld updated its original industry research ... benefit from an intensified focus on environmental policy. Over ... emission standards for power plants and a range of ... IBISWorld Industry Analyst Sarah Kahn, “a range of downstream ...
(Date:12/17/2014)... Once more, EMAAR has selected ... waste water treatment plant to phase one of BayLaSun, ... Two years ago Bioshaft successfully supplied and operated a ... residential towers with an occupancy of 900 residences. ... gallons per day and was signed on September 16th, ...
(Date:12/17/2014)... 2014  Vermillion, Inc. (NASDAQ: VRML ), ... announced the next step in its expanded strategy to ... with the naming of current Chief Operating Officer, ... while current Chairman of the Board and CEO ... These changes are effective January 1, 2015. ...
(Date:12/15/2014)... METTLER TOLEDO is pleased to announce ... V19 with PVM technology , is now available. ... measurement tool continuously captures high-resolution images under a ... automatically prepares a report pairing the most relevant ... changes. This compelling blend of high resolution images ...
Breaking Biology Technology:Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... University researchers have taken another step towards realizing ... enzyme mimics, opening the door for the development ... beyond nucleic acid targets. The blueprint for ... presence of targets such as small molecule medical ...
... Precision Therapeutics announced today that its President ... as CEO of the Year by the Pittsburgh ... ) (Photo: http://www.newscom.com/cgi-bin/prnh/20101015/NE83126 ... the accomplishments of 50 of southwestern Pennsylvania,s most ...
... Partners, Inc , the global entity resulting from the ... of this year, has launched a full suite of ... relates to Dual Energy X-Ray Absorptiometry ( DXA ). ... have formally launched state-of-the-art imaging solutions to address the ...
Cached Biology Technology:Catalyst sandwich 2Precision Therapeutics President and CEO Sean McDonald Recognized as Pittsburgh Technology Council Tech 50 CEO of the Year 2CoreLab Partners Launches New DXA Imaging Service Offerings 2
... compatible with ABI thermal cyclers, QPCR instruments ... characteristics can be sealed with heat ... Certified free of DNase, RNase and human ... Fisher Scientific, the world leader in serving ...
AVOID FREEZE/THAW CYCLES. Recognizes the ~32 kDa DNase IIα chain and the ~40 kDa proenzyme. DNase II causes both DNA condensation and DNA fragmentation. ...
BD BioCoat Vented Caps for 175 cm2 Flasks...
...
Biology Products: