Navigation Links
Fertility hope as study shows eggs survive in older ovaries

In research that could have broad implications for women's fertility treatments, scientists have found that despite their age, female mice have a renewable egg supply in their ovaries.

The discovery, by Professor Jock Findlay from Prince Henry's Institute and Associate Professor Jeff Kerr from Monash's Department of Anatomy and Cell Biology, has sparked controversy among biologists and challenged the theory, held for more than 50 years, that female mammals are born with a finite number of oocytes (eggs).

Two years ago, international researchers speculated that mice could continue to produce eggs throughout puberty and adulthood. Although their speculation caused debate throughout the scientific community, the scientists could not produce evidence to confirm their idea. However, Professor Findlay and Dr Kerr's research gives support to the theory. Their findings have been published in the July issue of Reproduction.

In the mammalian ovary, reproductive cells called oocytes (eggs) develop within ovarian follicles. In humans, the eggs are believed to die off from late in foetal life, after birth and into adult life. When egg numbers decline towards zero females can no longer reproduce ?resulting in the condition we know as menopause.

Professor Findlay, Dr Kerr and their colleagues have found that the total number of eggs in young and normal healthy adult female mice do not decline over time and that overall egg number is maintained for longer than previously thought. Their research suggests that mice have a source of renewable oocytes, Professor Findlay said.

"The mechanism behind renewable oocytes is still unknown," he said. "Although other scientists have suggested that the new eggs come from stem cells in the bone marrow or the ovary, we really don't know and further experimentation is needed to find out."

Dr Kerr said the phenomenon of egg regeneration in mice did not necessarily mean the same happened in humans. " But the mechanism could provide direction for ovarian stem cell research and help women with fertility conditions," he said.

One in six Australian couples faces some form of infertility. Due to the limitations and sensitivity of human ovaries, few studies have been conducted into the factors that influence egg survival, growth or death in relation to fertility.


'"/>

Source:Research Australia


Related biology news :

1. Fertility drugs given all-clear in new study
2. Bioartificial kidney under study at MCG
3. W.M. Keck Foundation funds study of friendly microbes
4. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
5. Genome-wide mouse study yields link to human leukemia
6. Clam embryo study shows pollutant mixture adversely affects nerve cell development
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. Same mutation aided evolution in many fish species, Stanford study finds
9. Sequencing of marine bacterium will help study of cell communication
10. Genetically modified rice in China benefits farmers health, study finds
11. A new study examines how shared pathogens affect host populations
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)... , May 16, 2016   EyeLock LLC ... today announced the opening of an IoT Center of ... strengthen and expand the development of embedded iris biometric ... unprecedented level of convenience and security with unmatched biometric ... one,s identity aside from DNA. EyeLock,s platform uses video ...
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... provide their customers enhanced security to access and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® ... provides a free webinar on Performing Quality Investigations: Getting to Root ... CT at no charge. , Incomplete investigations are still a major concern to ...
(Date:6/22/2016)... , June 22, 2016 Cell ... will allow them to produce up to one ... one lot within one week. These high-quality, consistent ... laboriously preparing cells and spend more time doing ... through a proprietary, high-volume manufacturing process that produces ...
Breaking Biology Technology: