Navigation Links
Feeling old?

Muscle in adults is constantly being built and broken down. As young adults we keep the two processes in balance, but when we age breakdown starts to win. However, adding the amino acid leucine to the diet of old individuals can set things straight again. This is the finding of research performed by Lydie Combaret, Dominique Dardevet and colleagues at the Human Nutrition Research Centre of Auvergne, INRA, Clermont-Ferrand, France.

After the age of 40, humans start loosing muscle at around 0.5?% per year. Immediately after a meal degradation of protein slows down and synthesis doubles. This process is triggered by the arrival of a plentiful supply of amino acids. In older animals this stimulus is less effective; synthesis slows down, and previous work also suggests that breakdown may be affected. While adding leucine to the diet restores protein building there was no knowledge about this supplement's effect on breakdown.

To address this, researchers compared protein breakdown in young (8-month) and old (22-month) rats. They discovered that the slow down in degradation that normally follows a meal does not occur in old animals, so there is excessive breakdown. But adding leucine to the diet restored a balanced metabolism.

The team of researchers believe that the age-related problem results from defective inhibition of ubiquitin-proteasome dependent proteoloysis, a complex degradative machinery that breaks down contractile muscle protein, and that leucine supplementation can fully restore correct function.

"Preventing muscle wasting is a major socio-economic and public health issue, that we may be able to combat with a leucine-rich diet," says senior co-author Didier Attaix.

Commenting on the work Michael Rennie from the University of Nottingham Medical School at Derby says: "This is exciting because it strengthens the idea of a co-ordinated linkage between the meal-related stimulation of protein synthesis and the inhibition of br eakdown."


'"/>

Source:Blackwell Publishing Ltd.


Related biology news :

1. Hope I die before I get old?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/26/2016)... DUBLIN , April 27, 2016 ... of the  "Global Multi-modal Biometrics Market 2016-2020"  report ... ) , The analysts forecast ... a CAGR of 15.49% during the period 2016-2020.  ... a number of sectors such as the healthcare, ...
(Date:4/15/2016)... April 15, 2016 Research ... Gait Biometrics Market 2016-2020,"  report to their offering.  ... ) , ,The global gait biometrics market is ... during the period 2016-2020. Gait analysis ... can be used to compute factors that are ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... San Diego, CA (PRWEB) , ... June 27, 2016 , ... ... mClinical solutions for clinical trials, announced today the Clinical Reach Virtual Patient ... and their care circle with the physician and clinical trial team. , Using the ...
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, ... second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical ... eBook by providing practical tips, tools, and strategies for clinical researchers. , “The ...
Breaking Biology Technology: