Navigation Links
Feeling old?

Muscle in adults is constantly being built and broken down. As young adults we keep the two processes in balance, but when we age breakdown starts to win. However, adding the amino acid leucine to the diet of old individuals can set things straight again. This is the finding of research performed by Lydie Combaret, Dominique Dardevet and colleagues at the Human Nutrition Research Centre of Auvergne, INRA, Clermont-Ferrand, France.

After the age of 40, humans start loosing muscle at around 0.5?% per year. Immediately after a meal degradation of protein slows down and synthesis doubles. This process is triggered by the arrival of a plentiful supply of amino acids. In older animals this stimulus is less effective; synthesis slows down, and previous work also suggests that breakdown may be affected. While adding leucine to the diet restores protein building there was no knowledge about this supplement's effect on breakdown.

To address this, researchers compared protein breakdown in young (8-month) and old (22-month) rats. They discovered that the slow down in degradation that normally follows a meal does not occur in old animals, so there is excessive breakdown. But adding leucine to the diet restored a balanced metabolism.

The team of researchers believe that the age-related problem results from defective inhibition of ubiquitin-proteasome dependent proteoloysis, a complex degradative machinery that breaks down contractile muscle protein, and that leucine supplementation can fully restore correct function.

"Preventing muscle wasting is a major socio-economic and public health issue, that we may be able to combat with a leucine-rich diet," says senior co-author Didier Attaix.

Commenting on the work Michael Rennie from the University of Nottingham Medical School at Derby says: "This is exciting because it strengthens the idea of a co-ordinated linkage between the meal-related stimulation of protein synthesis and the inhibition of br eakdown."


'"/>

Source:Blackwell Publishing Ltd.


Related biology news :

1. Hope I die before I get old?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... , Dec. 1, 2016   SoftServe ... announced BioLock , an electrocardiogram (ECG) biosensor ... monitoring, a key IoT asset. The smart system ... a vehicle,s steering wheel and mobile devices to ... touch. As vehicle technology advances, so ...
(Date:11/29/2016)... 2016 BioDirection, a privately held medical device ... objective detection of concussion and other traumatic brain injury ... a meeting with the U.S. Food and Drug Administration ... Package. During the meeting company representatives reviewed plans for ... to commencement of a planned pilot trial. ...
(Date:11/28/2016)... Nov. 28, 2016 "The ... of 16.79%" The biometric system market is in ... in the near future. The biometric system market is ... 2022, at a CAGR of 16.79% between 2016 and ... of biometric technology in smartphones, rising use of biometric ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... 2016 CytRx Corporation (NASDAQ: CYTR ... oncology, today announced the appointment of Earl Warren ... and private healthcare investor, to its Board of Directors. ... clinical and strategic experience at the highest level," said ... "As one of the world,s leading orthopedic surgeons, Dr. ...
(Date:12/2/2016)... ... December 01, 2016 , ... PhUSE will build on the ... US Single Day Events (SDE) to organize a multiple-day US conference. The first ... Topics of the pharmaceutical and life sciences industry will cover industry standards, data ...
(Date:12/2/2016)... ... ... Robots will storm the Prudential Center in Boston, MA during the ... held on the United Nations International Day of Persons with Disabilities, will highlight the ... Technologies is partnering with NTI to showcase how technology can help individuals with severe ...
(Date:11/30/2016)... CLEVELAND , Nov. 30, 2016  GenomOncology today announced ... Vice President of Medical Affairs.  Dr. Coleman ... enhancing the company,s proprietary knowledge-enabled platform. The GenomOncology software suite ... of genetic sequencing data and clinical decision support, from quality ... , ...
Breaking Biology Technology: