Navigation Links
Federal grant funds research on novel HIV therapy

of agents called neurokinin-1 receptor antagonists, may represent a new type of anti-HIV therapy, due to its ability to block HIV replication. The new program project grant will allow researchers to explore the potential of neurokinin-1 receptor (NK-1R) antagonists in a variety of ways.

In addition to studying direct antiviral action, the researchers will also look for effects on behavior. Because NK-1R antagonists are known to have antidepressant properties, any evidence of reduced anxiety-related behavior in animals may suggest potential important benefits for human HIV patients as well.

The grant includes four separate projects. Projects 1 and 2, led by virologist Wen-Zhe Ho, M.D., of Children's Hospital, and Dr. Douglas, respectively, aim to better understand the underlying mechanisms behind anti-HIV activity of NK-1R antagonists. The basic science research will particularly examine how these agents affect HIV-infected immune cells and how they also might protect the brain. "We know that substance P plays an important role in both the immune system and the central nervous system," said Dr. Douglas, "and we are testing the hypothesis that interfering with substance P receptors may reduce neurological injury from HIV infection."

Project 3, led by Andrew A. Lackner, Ph.D., D.V.M., director of the Tulane National Primate Research Center, will test whether NK-1R antagonists are safe in animals infected with simian immunodeficiency virus (SIV), which is analogous to HIV. This study aims to provide proof of concept for human trials under Project 4.

Project 4, led by Pablo Tebas, M.D., of the Department of Medicine at the University of Pennsylvania Medical School, will be a phase 1 (safety) trial of the NK-1R antagonist aprepitant (trade name Emend) in adults with HIV infection. Aprepitant is currently used to control nausea caused by chemotherapy; this project will determine whether the antagonist may also attack HIV infection in pati
'"/>

Source:Children's Hospital of Philadelphia


Page: 1 2 3

Related biology news :

1. Federal testing for mad cow disease a failure, law review editor says
2. Researcher gets NSF grant to create mutant maize lines
3. MSU researchers receive $4 million grant to uncover gene functions
4. Virulizin granted orphan drug status in Europe
5. New NIAID grants strengthen national biodefense and emerging infectious diseases research network
6. Asian immigrants in NYC not receiving HIV education at religious institutions
7. Boston University biomedical engineers win major grant for pursuit of the $1,000 Genome
8. Scientists win grants to develop $1,000 genome sequencing technology
9. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
10. W.M. Keck Foundation funds study of friendly microbes
11. WHO suspends Marburg work, appeals for new funds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Federal grant funds research novel HIV therapy

(Date:4/13/2015)... , April 13, 2015  higi, a leading cloud-based ... to more fully engage with their communities around health ... privacy protected and secure API.  ... the most accessible, affordable, and convenient vehicle to receive ... The API will allow higi,s ...
(Date:4/6/2015)... 6, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, ... 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND ... NXT-ID introduces a new revolutionary method and ... the use of miniature antenna modules for multiple ...
(Date:4/2/2015)... Fingerprint Cards (FPC) has received ... the distributor World Peace Industrial Group (WPI), part of ... the major part of the shipments will take place ... smartphone manufacturers in China . The ... communicated revenue guidance of + 1 000 MSEK for 2015.  ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... denominator of many chronic age-related diseases such as arthritis, gout, ... Medicine study, even in the absence of a disease, inflammation ... reducing healthspan that portion of our lives spent relatively ... the cover article in the October issue of Cell ...
... The Institute of Medicine (IOM) today announced the names ... 43rd annual meeting. Election to the IOM is considered ... and medicine and recognizes individuals who have demonstrated outstanding professional ... is an honor to welcome our highly distinguished colleagues to ...
... GREECE -- Green roofs, rooftops covered with vegetation, provide ... increasing in popularity worldwide. As more cities invest in ... can thrive in shallow planting conditions and with minimal ... recommendations for the use of turfgrass in green roof ...
Cached Biology News:Controlling the triggers of age-related inflammation could extend 'healthspan' 2Institute of Medicine Elects 70 New Members, 10 Foreign Associates 2Institute of Medicine Elects 70 New Members, 10 Foreign Associates 3Institute of Medicine Elects 70 New Members, 10 Foreign Associates 4Institute of Medicine Elects 70 New Members, 10 Foreign Associates 5Institute of Medicine Elects 70 New Members, 10 Foreign Associates 6Institute of Medicine Elects 70 New Members, 10 Foreign Associates 7Institute of Medicine Elects 70 New Members, 10 Foreign Associates 8Institute of Medicine Elects 70 New Members, 10 Foreign Associates 9Turfgrass tested in shallow green roof substrates 2
(Date:5/5/2015)... 5, 2015 Roka Bioscience, Inc. (NASDAQ: ROKA ... solutions for the detection of foodborne pathogens,  today announced that ... of America Merrill Lynch 2015 Health Care Conference on May ... Encore at the Wynn, Las Vegas NV. ... will be available through the investor relations section of Roka ...
(Date:5/5/2015)... Poway, CA (PRWEB) May 05, 2015 ... Pall Life Science Animal Health, Jeffrey Schaffer, DVM, ... , “With over 15 years of experience in ... be a great addition to our veterinarian lead ... Commercial Officer, explains. “Dr. Schaffer will be responsible ...
(Date:5/5/2015)... , May 05, 2015 Research ... has announced the addition of the ... to their offering. Macromolecules which ... undergo separation or are broken into smaller ... products. This separation requires various advanced systems ...
(Date:5/5/2015)... , May 5, 2015  Tikcro Technologies ... was approved to continue trading on OTCQB  Marketplace, ... OTCQB Marketplace allows for a continuous public ... Investors can have real-time quotes and market information ... The OTCQB Marketplace includes U.S. and international ...
Breaking Biology Technology:Leading Regenerative Veterinary Medicine Company, VetStem Biopharma announces the addition of Dr Jeffrey Schaffer as the Director of Veterinary Professional Services. 2Global Separation Systems Market in Biotechnology 2015-2019 - Trends and Forecasts for the $28 Billion Market 2Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2
... CBM ) announced that it will release fourth quarter and,full ... (Logo: http://www.newscom.com/cgi-bin/prnh/20000613/CAMBREXLOGO ), The Company will host ... financial results., ... and Full Year 2007 Earnings Conference Call, When: ...
... Enterprise,Forum will celebrate its 22nd year as a resource ... The event takes place,at 5:00 p.m. on Thursday, February ... Road in Ann Arbor, Michigan., At the event, ... Best New Product, Best Business Strategy, and Best,Presentation. In ...
... Directors, NEW YORK, Feb. 12 PeriCor Therapeutics ... director of the Company,s Board,of Directors effective February 7, ... analyst and the sole proprietor of the,consulting firm Above ... 1, 2008, Larry G. Pickering resigned as a director ...
Cached Biology Technology:New Enterprise Forum Celebrates 22nd Anniversary, Presents Annual Entrepreneur Awards to Randal Charlton & Others 2PeriCor Therapeutics Appoints K. Tucker Andersen to Board of Directors 2
... supplies, for 10 chips, provides the ... protein analysis with 10 chips on ... are 3 x 520 microliters Pro260 ... microliters Pro260 ladder (10-260 kD), 400 ...
...
... System to achieve high experimental throughput, ... information output 4 up to ... small-scale requirements provides users with proven ... Pichia pastoris, yeast, fungi or any ...
... preactivated with carbonyl diimidazole chemistry that covalently ... PS10 array contains the same binding chemistry ... an updated hydrophobic barrier coating. These arrays ... diameter spots spatially compatible with one column ...
Biology Products: