Navigation Links
Faults in newly discovered breast stem cells may lead to tumours

Victorian Breast Cancer Research Consortium scientists from The Walter and Eliza Hall Institute, using a mouse model, have discovered the rare stem cell that drives the formation of all breast tissue. This discovery lays an important foundation for understanding how normal breast tissue develops. The identification of the breast stem cell is also likely to provide clues about how breast cancer develops and how rogue cells evade current therapies.

Under normal circumstances, the newly identified breast stem cell will produce healthy tissue. But it is believed that an accumulation of genetic errors, perhaps combined with external influences and a family predisposition, could cause the breast stem cell or a "daughter" cell to produce faulty cells. In effect, the errant breast cell can become a tumour factory.

For many years, scientists and clinicians have been puzzled by the fact that women whose breast cancer cells have been apparently eliminated by chemotherapy sometimes experience a recurrence of their cancer. A cancerous stem cell could provide one possible explanation for such a recurrence.

Chemotherapy works by targeting cells that are dividing rapidly, which is typical behaviour of cancer cells. But an errant stem-like cell may be more resistant to chemotherapy because it divides more slowly. So while chemotherapy can eliminate the bulk of cancer cells, the tumour factory itself ?a breast cancer stem cell ?may survive months or years later.

In the context of international breast cancer research, the discovery of the breast stem cell is quite profound and will most likely form the basis of research in the area for years to come.

The ultimate objective is to create a drug that will, in effect, switch off breast cancer cells. To do this, the exact makeup of genes expressed by normal and rogue stem cells will need to be determined. Then a drug will be designed to engage with and neutralize the faulty feature of the stem ce ll.

Further research is now under way on excised human breast tumours to confirm the findings derived from the mouse model. The research team is from the WEHI Group of the Victorian Breast Cancer Research Consortium, which is funded by the Victorian state government through the Cancer Council Victoria.


'"/>

Source:Research Australia


Related biology news :

1. U of M researcher examines newly emerging deadly disease
2. Enzymes newly discovered role may make it target for arthritis treatment
3. Most common lung cancers may begin in newly discovered cells
4. Shorter colds, milder flu may follow from newly revealed immune mechanism
5. Hepatitis C therapy: Inhibiting newly discovered microDNA molecule
6. Drug discovery team to explore newly discovered deep-sea reefs
7. Study shows enzyme builds neurotransmitters via newly discovered pathway
8. Newly-discovered class of genes determines ?and restricts ?stem cell fate
9. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
10. New protein discovered by Hebrew University researchers
11. New RNA polymerase discovered in plants
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... Pa. , April 26, 2017  Genisphere ... delivery platform, has signed a collaborative and sponsored ... Dr. Silvia Muro . The overall goal ... and pharmacodynamics of various 3DNA designs and formulations ... involve targeting diseases of the vasculature as well ...
(Date:4/25/2017)... CA (PRWEB) , ... April 25, 2017 , ... ... of L3 Healthcare, is pleased to announce the company is now a certified ... The iMedNet software certification enables the company’s clinical research team to build, ...
(Date:4/25/2017)... Gatos, California (PRWEB) , ... April 25, 2017 ... ... business, Analytical Services and Metrology Partners.     , Covalent’s Analytical Services unit ... Most samples can be measured within 24 hours of receipt. There are no ...
(Date:4/24/2017)... 2017  Dante Labs announced today the offer of whole ... $900). While American individuals have been able to access WGS ... access WGS below EUR 1,000. The sequencing includes ... information to make informed decisions about disease monitoring, prevention, nutrition, ... ...
Breaking Biology Technology: