Navigation Links
Faults in newly discovered breast stem cells may lead to tumours

Victorian Breast Cancer Research Consortium scientists from The Walter and Eliza Hall Institute, using a mouse model, have discovered the rare stem cell that drives the formation of all breast tissue. This discovery lays an important foundation for understanding how normal breast tissue develops. The identification of the breast stem cell is also likely to provide clues about how breast cancer develops and how rogue cells evade current therapies.

Under normal circumstances, the newly identified breast stem cell will produce healthy tissue. But it is believed that an accumulation of genetic errors, perhaps combined with external influences and a family predisposition, could cause the breast stem cell or a "daughter" cell to produce faulty cells. In effect, the errant breast cell can become a tumour factory.

For many years, scientists and clinicians have been puzzled by the fact that women whose breast cancer cells have been apparently eliminated by chemotherapy sometimes experience a recurrence of their cancer. A cancerous stem cell could provide one possible explanation for such a recurrence.

Chemotherapy works by targeting cells that are dividing rapidly, which is typical behaviour of cancer cells. But an errant stem-like cell may be more resistant to chemotherapy because it divides more slowly. So while chemotherapy can eliminate the bulk of cancer cells, the tumour factory itself ?a breast cancer stem cell ?may survive months or years later.

In the context of international breast cancer research, the discovery of the breast stem cell is quite profound and will most likely form the basis of research in the area for years to come.

The ultimate objective is to create a drug that will, in effect, switch off breast cancer cells. To do this, the exact makeup of genes expressed by normal and rogue stem cells will need to be determined. Then a drug will be designed to engage with and neutralize the faulty feature of the stem ce ll.

Further research is now under way on excised human breast tumours to confirm the findings derived from the mouse model. The research team is from the WEHI Group of the Victorian Breast Cancer Research Consortium, which is funded by the Victorian state government through the Cancer Council Victoria.


'"/>

Source:Research Australia


Related biology news :

1. U of M researcher examines newly emerging deadly disease
2. Enzymes newly discovered role may make it target for arthritis treatment
3. Most common lung cancers may begin in newly discovered cells
4. Shorter colds, milder flu may follow from newly revealed immune mechanism
5. Hepatitis C therapy: Inhibiting newly discovered microDNA molecule
6. Drug discovery team to explore newly discovered deep-sea reefs
7. Study shows enzyme builds neurotransmitters via newly discovered pathway
8. Newly-discovered class of genes determines ?and restricts ?stem cell fate
9. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
10. New protein discovered by Hebrew University researchers
11. New RNA polymerase discovered in plants
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2017)... BLOOMINGTON, Ill. , Oct. 4, 2017  GCE Solutions, a ... powerful new data and document anonymization solution on October 4, 2017. ... the pharmaceutical field to comply with policy 0070 of the European ... documents and data. ... Innovation by GCE Solutions ...
(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use ... Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington ... Delta,s biometric boarding pass experience that ... integrated into the boarding process to allow eligible Delta SkyMiles Members who ...
(Date:6/14/2017)... June 15, 2017  IBM (NYSE: IBM ) is introducing ... event dedicated to developing collaboration between startups and global businesses, ... 15-17. During the event, nine startups will showcase the solutions ... various industries. France ... market, with a 30 percent increase in the number of ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading provider ... nationwide oncology Clinical Nurse Educator (CNE) network, which will launch ... for communication among health care professionals to enhance the patient ... office staff, and other health care professionals to help women ... cancer. ...
(Date:10/11/2017)... ... 11, 2017 , ... Singh Biotechnology today announced that the ... its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 single ... the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation of ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Club. The event entitled “Stem Cells and Their Regenerative Powers,” was ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., ...
(Date:10/10/2017)... PA (PRWEB) , ... October 10, 2017 , ... ... year’s recipients of 13 prestigious awards honoring scientists who have ... presented in a scheduled symposium during Pittcon 2018, the world’s leading conference and ...
Breaking Biology Technology: