Navigation Links
Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

tumor weight ranging from 44 to 72 percent compared with mice in the control groups. Combining the FAK-silencing liposome with docetaxel boosted tumor weight reduction to the 94-98 percent range.

These results also held up in experiments with ovarian cancer cell lines resistant to docetaxel and to the chemotherapy drug cisplatin.

The FAK-silencing liposome and the liposome with chemotherapy also reduced the incidence of cancer by between 20 and 50 percent in all tested cancer lines.

In addition to its anti-tumor effect, the researchers found that the therapeutic liposome attacked the tumor's blood supply, especially when combined with chemotherapy. By inducing cell suicide (apoptosis) among blood vessel cells, the treatment steeply reduced the number of small blood vessels feeding the tumor, cut the percentage of proliferating tumor cells and increased cell suicide among cancer cells.

Sood and Professor of Molecular Therapeutics Gabriel Lopez-Berestein, M.D., an expert in liposomal therapeutics, cite at least two factors for the success of the anti-FAK liposome.

"This particle is so small, it has no problem getting through the tumor's vasculature and into the tumor," Lopez-Berestein says. The FAK-targeting liposome ranges between 65 and 125 nanometers in diameter. Blood vessels that serve tumors are more porous than normal blood vessels, with pores of 100 to 780 nanometers wide. Normal blood vessel pores are 2 nanometers or less in diameter.

Second, the liposome -- a commercially available version known as DOPC -- has no electrical charge. Its neutrality provides an advantage over positively or negatively charged liposomes when it comes to binding with and penetrating cells.

The next step for the FAK siRNA-DOPC liposome is toxicity testing. "So far it appears to be very well-tolerated," Sood says. "We hope to develop this approach for clinical use in the future."

In addition to
'"/>

Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. Fatty fish protects against cancer
2. Nanospheres that block pain of sensitive teeth
3. Engineer ramps up protein production, develops versatile viral spheres
4. Penn researchers show how nanocylinders deliver medicine better than nanospheres
5. Biodegradable microspheres deliver time release vaccines, stimulate different immune response
6. MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools
7. Mice brains shrink during winter, impairing some learning and memory
8. Investigating brain shrinkage in alcoholics
9. Ultrasounds show mothers drinking shrinks fetal brain
10. Bird brains shrink from exposure to contaminants
11. Overfishing large sharks impacts entire marine ecosystem, shrinks shellfish supply
Post Your Comments:
(Date:12/19/2014)... , Dec. 18, 2014 Research and ... the addition of the "iPhone 5S Fingerprint ... Report" report to their offering. ... the acquisition of AuthenTec in July 2012, Apple ... 5S. It is currently the only device of ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ... "Micro Market Monitor: North America Perimeter Security Systems ... http://photos.prnewswire.com/prnh/20130307/600769 The North American ... CAGR of 3.6% from 2014 to 2019. Although the ... Canada is expected to grow ...
(Date:12/19/2014)... Calif. , Dec. 18, 2014  23andMe, Inc., ... of a study that pinpoints fine-scale differences in genetic ... States . Since immigrants first arrived ... United States has served as a meeting ... how American history and the ongoing mixing of peoples ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 323andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... of Earth observation missions expanding, it makes sense ... mission control from a combined Dedicated Control Room. ... and generating improved economic returns. , Flight control ... out of a combined Earth Observation (EO) Dedicated ...
... today announced details of a membership agreement with BioMed ... by its researchers. Pfizer,s BioMed Central membership arrangement ... for any researcher employed or funded by Pfizer when ... Central,s 190+ peer-reviewed open access journals. By funding open ...
... down on a Honduran naval boat as it criss-crossed the ... Central Americas most important seaports. Aboard the vessel, Miguel ... the distant horizon with some hint of concern on his ... the last few readings were definitely off. Miguel, along ...
Cached Biology News:ESA's Earth observation missions: Sharing teams and facilities boosts efficiency 2ESA's Earth observation missions: Sharing teams and facilities boosts efficiency 3Searching for pollution in the Caribbean 2Searching for pollution in the Caribbean 3Searching for pollution in the Caribbean 4Searching for pollution in the Caribbean 5Searching for pollution in the Caribbean 6Searching for pollution in the Caribbean 7Searching for pollution in the Caribbean 8
(Date:12/19/2014)... and Hershey, PA (PRWEB) December 19, 2014 ... BJCT), a leading developer and manufacturer of needle-free ... into an agreement with Immunomic Therapeutics, Inc. (“ITI”) ... needle-free injection device with its LAMP™ vaccine platform. ... option for an exclusive Worldwide license to the ...
(Date:12/19/2014)... December 19, 2014 Charm Sciences is ... for the Detection of Aflatoxin M1 in raw commingled ... independent third party validation. The peer reviewed report of ... the Institute for Agricultural and Fisheries Research (ILVO-T&V) has ... , Aflatoxin B1, the most toxic aflatoxin and a ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the ... Maroulis, Pharm.D. to the newly created position of Vice ... position, Dr. Maroulis will continue to manage the entire ... multi-site pharmacies as the company expands. Dr. Maroulis has ... he has served in many different capacities in the ...
(Date:12/19/2014)... -- Naurex Inc., a biopharmaceutical company leveraging its unique ... central nervous system, today announced that Norbert Riedel ... at the 33 rd annual J.P. Morgan Healthcare ... p.m. PST on Tuesday, January 13, 2015, at the ... About Naurex Inc. ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... businesses will receive funding for their technology development projects through ... , , BioSystem Development LLC of Middleton, will receive ... protein analysis. The company will use this award to finish ... university spin-off, we have not had the benefit of ...
... David Redick knows something about venture capital, having received ... entrepreneur. , ,Now Redick, a longtime denizen of Silicon ... the other side of the aisle with Badger ... focused on providing early stage funding and management services ...
... voted late Tuesday night to amend a bill granting ... newly created human embryonic stem cells would be denied. ... firms that do any research involving the destruction of ... cells from them after August 9, 2001. It ...
Cached Biology Technology:New Madison VC firm Badger Ventures looks for next big IT entrepreneurs 2New Madison VC firm Badger Ventures looks for next big IT entrepreneurs 3Bill would deny tax credits to firms creating stem-cell cultures 2
Highly sensive assay for detecting apoptosis in living cells. See detailed descriptions above in K250-25....
... E. coli Transformation Buffer Set are convenient ... coli cells for simple and highly efficient ... the requirement for heat shocking and related ... performed by adding DNA to Z-Competent cells ...
... *SizeSep 400 Spun Columns: For rapid intermediate purification ... - *Prepacked ... containing 0.15% Kathon CG/IcP Biocide. *Remove all ... *Extremely useful in the construction of size-selected ...
... automated perfusion system. For real-time or ... biophysics, electrochemistry, or general liquid-handling research ... millisecond accuracy Run experiments automatically ... accuracy and flexibility Turnkey perfusion ...
Biology Products: