Navigation Links
Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

A molecular "off" switch packaged in a tiny sphere penetrates deeply into ovarian cancer tumor cells, stifling a troublesome protein and drastically reducing the size of tumors, researchers at The University of Texas M. D. Anderson Cancer Center report in the Aug. 15 edition of Clinical Cancer Research.

The mouse model experiment, featured on the cover of the journal, demonstrates a potent delivery system for short interfering RNA (siRNA) to attack cancer, says senior author Anil Sood, M.D., associate professor in the Departments of Gynecologic Oncology and Cancer Biology at M. D. Anderson.

"Short interfering RNA is a great technology we can use to silence genes, shutting down production of harmful proteins," Sood says. "It works well in the lab, but the question has been how to get it into tumors." Short pieces of RNA don't make it to a tumor without being injected directly, and injection methods used in the lab are not practical for clinical use.

The research team took siRNA that targets a protein that helps ovarian cancer cells survive and spread and rolled it into a liposome -- a lipid ball so small that its dimensions are measured in nanometers (billionths of a meter).

Getting the siRNA inside tumor cells is important, Sood said, because the targeted protein, focal adhesion kinase (FAK), is inside the cell, rather than on the cell surface where most proteins targeted by cancer drugs are found. "Targets like FAK, which are difficult to target with a drug, can be attacked with this liposomal siRNA approach, which penetrates deeply into the tumor," Sood said.

Mice infected with three human ovarian cancer cell lines derived from women with advanced cancer were treated for 3-5 weeks. They received liposomes that contained either the FAK siRNA, a control siRNA, or were empty. Some mice received siRNA liposomes plus the chemotherapy docetaxel.

Mice receiving the FAK-silencing liposome had reductions in mean
'"/>

Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. Fatty fish protects against cancer
2. Nanospheres that block pain of sensitive teeth
3. Engineer ramps up protein production, develops versatile viral spheres
4. Penn researchers show how nanocylinders deliver medicine better than nanospheres
5. Biodegradable microspheres deliver time release vaccines, stimulate different immune response
6. MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools
7. Mice brains shrink during winter, impairing some learning and memory
8. Investigating brain shrinkage in alcoholics
9. Ultrasounds show mothers drinking shrinks fetal brain
10. Bird brains shrink from exposure to contaminants
11. Overfishing large sharks impacts entire marine ecosystem, shrinks shellfish supply
Post Your Comments:
(Date:7/23/2015)... July 23, 2015 Research and Markets ... the "Global Outlook of the Biometrics Industry ... The global biometrics market is likely ... commercial applications owing to the uptake of multiple ... transformation that enhances the growth of biometrics in ...
(Date:7/21/2015)... 21, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market ... that it has filed provisional patent 62/192218 for ... This invention highlights next generation payment ... account, but also the user using unique personal ...
(Date:7/20/2015)... 20, 2015  Acuity Market Intelligence,s latest research ... of Commerce and Privacy" forecasts that between 2014 ... will be downloaded to smart mobile devices by ... market is projected to generate more than $67.9 ... seven-year forecast period.    "Biometrics is ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2
... the molecular process that can shut down a marauding, ... who suffer battlefield casualties, heart attacks, strokes, automobile accidents ... the January edition of Molecular Immunology. , The ... of a reaction first observed in the lab by ...
... on a diet, while others have expanding waistlines. , ... due to global climate change, speculates Prof. Yoram Yom-Tov ... been measuring the evolving body sizes of birds and ... , Changes are happening primarily in higher latitudes, where ...
... mutations cause disease. What are largely unknown are the ... molecular level, giving rise to clinically observable symptoms in ... by scientists at the Buck Institute for Age Research, ... many inherited genetic diseases. These predictions involve tens of ...
Cached Biology News:Research could lead to way to halt deadly immune response 2Research could lead to way to halt deadly immune response 3Animals cope with climate change at the dinner table 2Comprehensive study using bioinformatics predicts the molecular causes of many genetic diseases 2Comprehensive study using bioinformatics predicts the molecular causes of many genetic diseases 3
(Date:7/29/2015)... , July 29, 2015  AsureQuality and Ubiquitome ... testing for applications in food and primary production ... powered real-time PCR device, the Freedom4. ... through to the supermarket shelf for producers, processors ... involvement in animal disease control and pest management ...
(Date:7/29/2015)... ... July 29, 2015 , ... Brady (NYSE:BRC), a global leader ... . To align chemical container labeling with OSHA’s updated Hazard Communication (HazCom) Standard ... an example of an accurate label, and pictogram uses and meanings. , “With ...
(Date:7/29/2015)... -- Pfenex Inc. (NYSE MKT: PFNX) announced today that its ... Thursday, August 13, 2015, before the open of market.  ... a conference call to discuss the financial results and ... financial results and business update will be publicly distributed ... (US) or 1-412-542-4131 (international) and reference Pfenex to access ...
(Date:7/29/2015)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... announce that the final design specifications of its ... for industrial and regulatory testing will now be ... mark clearance to market the injector in ... (Photo: http://photos.prnewswire.com/prnh/20150729/248373 )  The RCI-02 ...
Breaking Biology Technology:AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2Brady Announces a New GHS Label Guide 2Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5
... Weikang Bio-Technology Group Co., Inc. (OTC QB: WKBT) ... marketer of Traditional Chinese Medicine (TCM), Western prescription and ... the People,s Republic of China, today announced its financial ... Fiscal 2010 Financial Highlights ...
... BELLEVUE, Wash., March 21, 2011 Coinstar, Inc. ... will invest in SoloHealth, a consumer-driven healthcare technology ... information kiosks, including its award-winning EyeSite® product and ... disclosed. "As a leader in ...
... DeComo, Chairman of the Board of Directors of the ... investments and customized company formation and business growth services ... W. Manzetti and the Pittsburgh Life Sciences Greenhouse for ... category winner at the 2011 Pennsylvania Technology Awards ...
Cached Biology Technology:Weikang Bio-Technology Announces Fiscal 2010 Financial Results 2Weikang Bio-Technology Announces Fiscal 2010 Financial Results 3Weikang Bio-Technology Announces Fiscal 2010 Financial Results 4Weikang Bio-Technology Announces Fiscal 2010 Financial Results 5Weikang Bio-Technology Announces Fiscal 2010 Financial Results 6Weikang Bio-Technology Announces Fiscal 2010 Financial Results 7Coinstar to Invest in SoloHealth 2Coinstar to Invest in SoloHealth 3John W. Manzetti and the Pittsburgh Life Sciences Greenhouse Recognized as 2011 Outstanding Leader in Technology 2
Human HVEM/TNFRSF14 Allophycocyanin MAb (Clone 94801)...
LAL Chromogenic Endpoint assay...
RayBio Human Atherosclerosis Antibody Array 1.1 (4) with Accessory, detects 40 inflammatory factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Request Info...
Biology Products: