Navigation Links
Fat screen delivers plant-derived chemical with antidiabetic effects

After screening hundreds of compounds for their effects on fat development, researchers have discovered that an ingredient found in some plants fights diabetes in mice without some of the side effects attributed to other antidiabetes drugs. The chemical they pinpointed, known as harmine, was first isolated more than 150 years ago from plants traditionally included in ritual and medicinal preparations around the world, the team reports in the May issue of the journal Cell Metabolism, published by Cell Press.

The work suggests a new approach for treating insulin resistance that might complement the use of preexisting drugs and, more generally, provides validation for fat cell screens as a promising strategy for identifying new metabolic drugs, according to the researchers.

While harmine itself has effects on the central nervous system that may preclude its use, "it may eventually be possible to separate the nervous system and metabolic effects of harmine through optimization of the chemical structure," said Peter Tontonoz, a Howard Hughes Medical Institute investigator at the University of California, Los Angeles. Harmine has been known to induce hallucinations, convulsions, and tremors.

The principal class of drugs prescribed for obesity-related diabetes, called thiazolidinediones or TZDs, work through a counterintuitive mechanism: they restore insulin sensitivity by activating a central promoter of fat tissue production called peroxisome proliferator-activated receptor ã (PPARã).

"The current explanation for this paradoxical mode of action is the idea that the body needs a place to store lipids," Tontonoz said. "If the body becomes less able to store lipids in fat, it may deposit in other tissues," where it can spur disease.

Despite their efficacy, the development and clinical use of TZDs is limited by adverse effects such as fluid retention, weight gain, congestive heart failure, liver toxicity, and potential cancer ri sks, the researchers said. Therefore, alternative approaches to treating insulin resistance are needed.

The researchers speculated that other small molecules that promote fat tissue by distinct mechanisms could be candidates for novel insulin sensitizers. By running a technologically advanced screen of more than 500 bioactive compounds, the researchers found that harmine has such a positive effect on fat. The fat cells under examination were manipulated such that they literally lit up when fat-boosting PPARã became active.

Further study of harmine's effects in diabetic mice found that the chemical increases insulin sensitivity in a manner similar to, though more roundabout than, the predominant antidiabetes drugs. Rather than triggering PPARã directly, the chemical blocks a pathway that normally inhibits fat cells' production. "Harmine inhibits an inhibitor for a net positive effect on fat" that ultimately appears to restore insulin response without some of the side effects attributed to TZDs, Tontonoz said.

The findings provide "a second example of a small molecule that both promotes fat cell differentiation in vitro and improves glucose tolerance in vivo," Tontonoz's team concluded. The biological activities of harmine and TZDs underscore the fact that links between fat tissue and insulin resistance are complex and are likely to involve not only changes in fat tissue differentiation and cell number but also changes in the fat cells' function, they said.


'"/>

Source:Cell Press


Related biology news :

1. MetaChip provides quick, efficient toxicity screening of potential drugs
2. Boosting HIV screening can increase survival and is cost effective
3. Researchers develop assay that could be applied to drug screening
4. Aptamer-based Biosensor screens Air Force personnel and equipment
5. NIH creates nationwide network of molecular libraries screening centers
6. UT Southwestern researchers develop screening test for cells that activate immune system
7. Gene screen for breast cancer better than pathologists eye
8. Newborn screening can cause unnecessary parental stress
9. Handling HPV vaccines and screening: The views of 100 authors
10. Pesticides need sunscreen to beat the heat
11. New sunscreen ingredient to heal sunburn and help prevent skin cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... , April 28, 2016 First quarter ... (139.9), up 966% compared with the first quarter of 2015 ... totaled SEK 589.1 M (loss: 18.8) and the operating margin was ... (loss: 0.32) Cash flow from operations was SEK 249.9 ... 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. The ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... Mich. , May 26, 2016  Agriculture nutrients ... Des Moines, Iowa is running their ... Lake Erie and coastal regions ... key to preventing this widespread issue. NECi ... Upper Peninsula, developed a new, easy to ...
(Date:5/26/2016)... YORK , May 26, 2016 ... today that it will be a featured presenter at the ... in New York City at the ... Denis Corin , Q BioMed Inc. CEO, is scheduled to ... will cover the company,s business strategy, recent developments and outline ...
(Date:5/26/2016)... ... May 26, 2016 , ... After several promising ... at the City of Knowledge in Panama, a 6 year-old Duchenne’s muscular ... US earlier this year following FDA approval of a second application for a ...
(Date:5/26/2016)... ... May 26, 2016 , ... FireflySci has been manufacturing ... laboratories all over the globe. Their cute firefly logo has been spreading to ... FireflySci makes spectrophotometer calibration standards that never require recalibration. These revolutionary standards ...
Breaking Biology Technology: