Navigation Links
Fat fish put obesity on the hook

Everyone knows that eating lean fish helps slim waistlines, but researchers from the Center for the Study of Weight Regulation and Associated Disorders at Oregon Health and Science University in Portland, OR, have found a new way fish can help eliminate obesity. In a study to be published in the July 2007 print issue of The FASEB Journal, researchers describe the first genetic model of obesity in a fish. Having this model should greatly accelerate the development of new drugs to help people lose weight and keep it off.

According to corresponding author Roger Cone, “Being able to model human disorders like obesity in zebrafish allows scientists to understand the molecular basis of disease. This may ultimately increase the efficiency and power of the drug discovery process, thus bringing new medicines to the market faster and cheaper.”

In the study, researchers caused obesity in zebrafish by introducing the same type of genetic mutation that causes severe obesity in humans. The genetic change blocks the activity of a receptor, the melanocortin-4 receptor, which is at the heart of a “device” in our brains called the “adipostat.” The adipostat regulates body weight homeostatically, like the thermostat in a house, and works to keep long-term energy stores—a.k.a. body fat—constant. The adipostat is what makes it difficult for people to lose weight and keep it off.

“Americans—even children—are getting fat at an alarming rate,” said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, “and with this model, we are a step closer to temporarily turning off or diminishing the fat-storing mechanisms that were once crucial to the survival of our species. The zebrafish has become a model animal for the study of many diseases because it has a backbone and because its genetics have been well described. This is one more example of how basic experimental biology – zoology physiology and genetics in this case – can be brought to bear on human problems.”

According the U.S. Centers for Disease Control and Prevention, the prevalence of overweight and obesity have risen steadily over the past 30 years. Among adults aged 20–74 years the prevalence of obesity increased from 15.0% (1976–1980) to 32.9% (2003–2004). For children aged 2–5 years, the prevalence of overweight increased from 5.0% to 13.9%; for those aged 6–11 years, prevalence increased from 6.5% to 18.8%; and for those aged 12–19 years, prevalence increased from 5.0% to 17.4%. Being overweight or obese increases the risk of many diseases and health conditions, including, but not limited to: hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis, sleep apnea and respiratory problems, and some types of cancer.


'"/>

Source:Federation of American Societies for Experimental Biology


Related biology news :

1. Canadian youth 4th highest in international obesity study
2. Weight control protein may yield antiobesity drugs
3. Contagious obesity? Identifying the human adenoviruses that may make us fat
4. Study by Einstein researchers could lead to a novel strategy for treating obesity
5. Major obesity gene is lost in the shuffle
6. Sleep deprivation doubles risks of obesity in both children and adults
7. Higher levels of obesity associated with greater health risks
8. Dragonflys metabolic disease provides clues about human obesity
9. Major link in brain-obesity puzzle found
10. Magic Beans -- Anti-obesity soya could help prevent diabetes
11. Natural gut hormone offers hope for new obesity drug

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2017)... , March 9, 2017 4Dx has publicly ... Lung Imaging Workshop at the University of Pennsylvania. Founder ... to deliver the latest data to world leaders in ... brings together leaders at the forefront of the industry ... imaging. "The quality of the imaging ...
(Date:3/6/2017)... , March 6, 2017 ... sales technology, today announced Predictive Sales Coach TM ... infusing actionable sales intelligence into Salesforce. This unique ... enable their sales organizations with deep knowledge of ... allow for intelligent engagement. Predictive Sales Coach extends ...
(Date:3/2/2017)... 2017 Australian stem cell and regenerative medicine ... signed an agreement with the Monash Lung Biology Network, ... Institute and Department of Pharmacology at Monash University, ... study to support the use of Cymerus™ mesenchymal stem ... Asthma is a chronic, long term lung condition ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... ... March 30, 2017 , ... Accelovance, Inc., a global ... the hiring of Bruce Wakeman into the role of VP US Business Development ... Proposals & Marketing. , Bruce brings Accelovance over 20 years’ experience in CROs, ...
(Date:3/30/2017)... March 30, 2017 In today,s ... (NASDAQ: AGEN), Intrexon Corp. (NYSE: XON), Progenics Pharmaceuticals Inc. ... CXRX ). According an article on Barron,s, Credit Suisse upgraded ... on Tuesday, March 21 st , 2017. These stocks research ... free at: ...
(Date:3/29/2017)... OF PRUSSIA, Pa. , March 29, 2017 /PRNewswire/ ... to care, which is why CSL Behring awards Local ... work of rare disease patient groups. These groups tackle ... voices are heard on Capitol Hill and in statehouses ... funding cycle, the community-based grant was awarded to New ...
(Date:3/29/2017)... year,s petition to the White House signed by 120,000 ... generate awareness on the importance of new organic medicines and nutritional ... place. ... this month Health Advance (OTC PINK: HADV ), ... announced its endeavors on this generally recognized as safe ...
Breaking Biology Technology: