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Faster, low cost sequencing technologies needed to drive era of personalized medicine

ze of a dust mite, by 2009.

The award to Zhang and his team was one of nine grants given by the NIH to achieve the $1,000 genome goal. Zhang's effort also joins two other ASU research teams, led by Stuart Lindsay and Peter Williams, who have more than $2 million in other DNA sequencing projects funded at ASU.

"There are currently only 36 grants in the entire NHGRI sequencing program, so it's quite remarkable that ASU has three of them, which is almost 10 percent of the program," Williams said.

Williams, professor of chemistry and biochemistry, is working on a $100,000 genome project, part of the five-year goal of the NHGRI to drop the current price to a hundredth of the cost. His goal is to selectively sequence genes known to be involved in disease in a matter of hours, and for a few hundred dollars.

Lindsay, who is director of the Biodesign Institute's Center for Single Molecule Biophysics, is engaged in a different separately funded $1,000 genome project. Lindsay is threading DNA through a molecular ring, in this case a sugar called cyclodextrin, that can read the DNA sequence by measuring the differences in friction as the molecule is pulled through the ring.
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Source:Arizona State University


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