Navigation Links
Fast and slow -- How the spinal cord controls the speed of movement

Using a state-of-the-art technique to map neurons in the spinal cord of a larval zebrafish, Cornell University scientists have found a surprising pattern of activity that regulates the speed of the fish’s movement. The research may have long-term implications for treating injured human spinal cords and Parkinson’s disease, where movements slow down and become erratic.

The study, "A Topographic Map of Recruitment in Spinal Cord," published in the March 1 issue of the journal Nature, maps how neurons in the bottom of the fish’s spinal cord become active during slow movements, while cells further up the spinal cord activate as movements speed up.

By removing specific neurons in the lower spinal cord with laser beams, the researchers rendered the fish incapable of slow movements. By removing nerves further up the backbone, the fish had difficulty moving fast.

"No one had any idea that organization like this existed in a spinal cord," said Joseph Fetcho, a Cornell professor of neurobiology and behavior and an author of the study. "Now that we know the pattern, we can begin to ask how that changes in disease states."

David McLean, Cornell postdoctoral researcher in Fetcho’s laboratory, was the first person to discover the pattern of neural activation and how it was associated with speed of movement. He is the lead author on the study.

The researchers worked with 4 millimeter-long larval zebrafish (Danio rerio) because they are transparent and researchers can see their cells. Fetcho and his colleagues injected the fishes?spinal cords with a fluorescent dye, which then lit up when calcium ions flooded in as the nerve cells activated. A confocal microscope with lasers allowed the researchers to image the cells at very high resolutions. Using this set up, they watched nerve cells light up as the animals moved at different speeds.

While no one knows how this pattern relates to other vertebrates, the research opens a door toward basic understanding of the architecture and function of nerves in spinal cords. With regard to regeneration of spinal cords following injury, for example, medical researchers need a template for a normal spinal cord in order to know if nerves are re-growing normally, Fetcho said.

In Parkinson’s disease, researchers believe that a neurotransmitter released by brain cells may contribute to activating a system of nerves and muscles that allow for faster movement. They suspect that damage to these brain cells may disrupt the release of dopamine, further complicating free movement. Fetcho and his group are building a transgenic line of fish with those brain cells labeled so they may be targeted and removed with lasers.
'"/>

Source:Cornell University News Service


Related biology news :

1. Stem cell treatment improves mobility after spinal cord injury
2. Combination therapy leads to partial recovery from spinal cord injury in rats
3. Purdue scientists may have found key to halting spinal cord damage
4. Researchers find molecule that inhibits regrowth of spinal nerve cells
5. Gradient guides nerve growth down spinal cord
6. One small step means giant leap for spinal cord research
7. New study identifies key gene in development of connections between brain and spinal cord
8. Protein fingerprint in spinal fluid could spot Alzheimers disease
9. Thinking with the spinal cord?
10. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find
11. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
(Date:3/24/2017)... , March 24, 2017 The Controller General ... Controller Mr. Abdulla Algeen have received the prestigious international IAIR ... Continue Reading ... ... picture) and Deputy Controller Abdulla Algeen (small picture on the right) have ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... September 20, 2017 , ... ... leading global provider of engineering, architecture, project controls, construction management, commissioning and ... today announced the unveiling of the iCON™ brand which represents the collective ...
(Date:9/20/2017)... ... September 20, 2017 , ... RoviSys, a leading independent provider ... opening of an office in Taipei, Taiwan. This new location allows RoviSys to ... new relationships in the region. Located in the Neihu area of Taipei, the ...
(Date:9/19/2017)... Vernon HIlls, IL (PRWEB) , ... September 19, 2017 , ... ... use, harsh environments and time. The pocket testers even stand upright with a new ... in the lab or out in the field who need to test water quality. ...
(Date:9/19/2017)... (PRWEB) , ... September 19, ... ... York State Department of Financial Services (NYS DFS) cybersecurity regulations have ... banking, finance and insurance organizations operating in the state (“Covered Entities”) to ...
Breaking Biology Technology: