Navigation Links
Fantastic Voyage: A new nanoscale view of the biological world

Echoing the journey through the human body in Fantastic Voyage, doctors might soon be able to track individual donor cells after a transplant, or to find where and how much of a cancer treatment drug there is within a cell. New technology described in a study published today in the open access journal Journal of Biology makes it possible to image and quantify molecules within individual mammalian or bacterial cells. Claude Lechene and colleagues describe the development of multi-isotope imaging mass spectrometry (MIMS), which has applications in all fields of biology and biomedical research.

"This method allows us to see what has never been seen before, and to measure what has never before been measured," Lechene says. "Imagine looking into a building, slice by slice. You can see not only that it contains apartments, but also that each apartment contains a refrigerator. You can see that there are tomatoes in the refrigerator of one apartment, and potatoes in the refrigerator of another. You can count how many there are and measure how fast they are used and replaced. It is this level of resolution and quantification that MIMS makes possible within cells."

Lechene, of Harvard Medical School and Brigham and Women's Hospital in the US, worked with colleagues from around the world to develop and test the new methodology.

A beam of ions is used to bombard the surface atoms of the biological sample, and a fraction of the atoms are emitted and ionized. These "secondary ions" can then be manipulated with ion optics ?in the way lenses and prisms manipulate visible light - to create an atomic mass image of the sample. Lechene et al. developed MIMS by combining the use of a novel secondary-ion mass spectrometer developed by Georges Slodzian, from the Université Paris-Sud in France, labeling with stable isotopes and building quantitative image-analysis software.

MIMS can generate quantitative, three-dimensional images of proteins, DNA
'"/>

Source:BioMed Central


Page: 1 2

Related biology news :

1. Marine sponge yields nanoscale secrets
2. Rice scientists make first nanoscale pH meter
3. Blood-compatible nanoscale materials possible using heparin
4. Embryonic stem cells do better on bumpy nanoscale mattress
5. Spelling out cancer on the nanoscale
6. Researchers to develop active nanoscale surfaces for biological separations
7. Bones at the nanoscale
8. Penn researcher shows that DNA gets kinky easily at the nanoscale
9. NYU researchers simulate molecular biological clock
10. Automatic extraction of gene/protein biological functions from biomedical text
11. DuPonts first biologically derived polymer receives global recognition
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Fantastic Voyage new nanoscale view the biological world

(Date:5/23/2013)... for the overall health, development, and academic success ... in ensuring that all students have opportunities to ... of vigorous or moderate-intensity physical activity, says a ... Recent estimates suggest that only about half of ... better health and development. The report recommends ...
(Date:5/23/2013)... one of the world,s largest and fastest growing ... journal, Frontiers in Bioengineering and Biotechnology . ... specialties, Frontiers in Bioengineering and Biotechnology ... and emerging bioengineering and biotechnology research to be ... Bioengineering and Biotechnology will provide an open-science ...
(Date:5/22/2013)... to improve durability in fuel cell powered buses, ... discovered links between electrode degradation processes and bus ... effects of electrode degradation stressors in the operating ... , The findings of the study, led by ... in a long-term study at Burnaby-based Ballard Power ...
Breaking Biology News(10 mins):Schools should provide opportunities for 60 minutes of daily physical activity to all students 2Schools should provide opportunities for 60 minutes of daily physical activity to all students 3Frontiers launches new open-access journal in Bioengineering and Biotechnology 2Tests lead to doubling of fuel cell life 2
... scientists at the University of Missouri Center for Agroforestry ... can trap and break down veterinary antibiotics in manure ... can be effective in protecting water quality, controlling erosion ... beauty of it," said Keith Goyne, assistant professor of ...
... master gene called SRC-3 (steroid receptor coactivator 3) not only ... the transcription of a genetic message into a protein, it ... cell motility or movement a key element of cancer ... ) researchers and collaborators in a report that appears in ...
... have streamlined the process for synthesizing a family of compounds ... and have found that they represent a unique category of ... of the Journal of the American Chemical Society . ... as the kinamycins, which are naturally produced by bacteria during ...
Cached Biology News:Plant buffers may limit spread of antibiotics in animal waste 2Master gene SRC-3 enables breast cancer growth, invasion 2Scientists synthesize unique family of anti-cancer compounds 2
(Date:5/23/2013)...  Saddleback Memorial Medical Center in Laguna ... on the West Coast to perform a hysterectomy using ... women with a state-of-the-art, minimally invasive approach to gynecological ... , M.D., a highly regarded Orange County ... minimally invasive surgery at Saddleback Memorial, led the surgical ...
(Date:5/23/2013)... May 23, 2013 Northwest Biotherapeutics (NASDAQ: ... DCVax ® personalized immune therapies for solid tumor ... at this year,s American Society Of Clinical Oncology (ASCO) ... its leadership role in immune therapy.  (Logo: ... meeting is the pre-eminent conference focused on clinical treatment ...
(Date:5/23/2013)... 23, 2013 Pusan National University Yangsan ... biotherapeutics and contract research company focused on research ... announced today a publication reporting the induction of ... oncolytic and immunotherapeutic vaccinia JX-594 (pexastimogene devacirepvec; Jennerex ... in the May 15 th , 2013 issue ...
(Date:5/23/2013)... May 23, 2013 Watlow®, an ... complete thermal systems, recently introduced its new catalog, ... of experience in designing and manufacturing industrial heaters, ... products to serve diverse customer needs. , A ... at the beginning of the book. These options ...
Breaking Biology Technology:Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 2NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 3Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3Watlow Introduces Its New Industrial Heater Catalog 2
... Wis. - With plans to erect as many as ... Systems is thinking about needs well beyond its existing ... ,Steve Dickmann, Epic's chief administrative officer, said the company anticipates ... existing employee count of 2,500. In addition, there remains plenty ...
... be the answer to a question you aren't even asking ... connect you with your customers - and your customers with ... your reputation and sales. Here are several potential brand threats ... sophisticated, and suggestions for dealing with them. , , Bad ...
... the lower case "i" next to a word as a way ... and glory may be possible, the chances of creating a long-lasting, ... is the exclusive longevity of its unique name, and for that ... Panasonic and not iTV. , ,Terms like interactive and ...
Cached Biology Technology:Epic Systems will build well beyond current staff size 2Protecting your business against online brand abuse 2Protecting your business against online brand abuse 3The I of the storm: iPhones, iPains, and iProblems 2The I of the storm: iPhones, iPains, and iProblems 3The I of the storm: iPhones, iPains, and iProblems 4
... This CLS number is ... created to easily match ... showing no availability yet, ... old Sigma-Aldrich number (Z36,327-8) ...
... Grace's medium were developed in several laboratories ... of these modifications were developed by Dr. ... derived from the cabbage looper,Tricoplusia ni. This ... The medium when properly supplemented has been ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... T7•Tag ® Ek Adaptor encodes a ... binding site (rbs), ATG translation initation codon, ... T7•Tag is a small epitope tag (11 ... the target protein with T7•Tag Monoclonal Antibody ...
Biology Products: