Navigation Links
Failure of 'scout cells' may lead to cancer in transplant patients

me people have a normal genetic difference that causes them to have lower levels of IFNg in the body and others to have higher levels.

The researchers then injected white blood cells from each of the two groups of people into immune-deficient mice. All the people were healthy and tested positive for EBV.

They found that white blood cells from people who had the genetic difference for lower IFNgƒnlevels were more likely to cause EBV-related cancer in the mice than cells from people with the genetic difference for higher IFNg levels. They also found that blocking TGFb prevented the EBV-related cancer.

We hypothesize that the balance between IFNgƒnand TGFb is probably important in determining whether or not the cancer develops, VanBuskirk says.

In the new study, for example, adding IFNg to TGFb prevented the scout cells from changing and allowed them to strongly re-stimulate the memory T cells.

If our hypothesis proves to be true, VanBuskirk says, it may one day be possible to identify transplant patients who are at greater risk for PTLD and to develop new therapies that prevent or treat the disease.


'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Implanted Devices Detect High-Risk Heart Failure Patients
2. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
3. Failure to meet United Nations sanitation target could affect millions of the worlds poorest
4. Two chemicals boost immune cells ability to fight HIV without gene therapy
5. Once given no respect, cells tiny RNAS take drivers seat
6. How HIV disables the cells call for help
7. Stem cells electric abilities might help their safe clinical use
8. Scientists discover the molecular switch for nerve cells insulating jelly rolls
9. New insight into machinery of immune cells tentacles
10. Allergy cells can aggravate cancer and psoriasis
11. A key antibody, IgG, links cells capture and disposal of germs
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Failure scout cells may lead cancer transplant patients

(Date:9/17/2014)... Researchers at UTSouthwestern Medical Center have found that ... E, called apoE3, helps repair the lining of blood ... get the benefit of this repair, putting them at ... we have identified one mechanism by which apoE3 promotes ... apoE4, is detrimental," said Dr. Philip Shaul , ...
(Date:9/17/2014)... As the United Kingdom forms a new crime unit ... an uproar last year over horse meat being passed ... a technique for detecting meat adulteration. They describe their ... in ACS, Journal of Agricultural and Food Chemistry ... fraud is a major global economic problem. But they ...
(Date:9/16/2014)... morbidity amongst women in Australia is increased by ... today (17 September) in BJOG: An International ... generally enjoy high standards of living; however, existing ... particular between indigenous and non indigenous Australians. , ... impact of socioeconomic position on severe maternal morbidities ...
Breaking Biology News(10 mins):Protein variant may boost cardiovascular risk by hindering blood vessel repair 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 3
... L. Billiar, associate professor of biomedical engineering at Worcester ... to work at the National University of Ireland Galway ... who will be in Ireland for the 2009-10 academic ... faculty to be awarded a Fulbright Scholar grant. ...
... the oil tanker Exxon Valdez was exiting Alaska,s Prince William ... the night. What happened next is considered one of the ... spilled into the pristine Alaskan waters, eventually covering 11,000 square ... the amount of oil spilled in the Exxon Valdez accident. ...
... May 13, 2009 The Association for Molecular Pathology ... American Civil Liberties Union (ACLU) and the Public Patent ... two human genes associated with breast and ovarian cancer ... mutations along these two genes, known as BRCA1 and ...
Cached Biology News:WPI professor receives Fulbright Scholarship to work on tissue engineering in Ireland 2UCSB scientists document fate of huge oil slicks from seeps at coal oil point 2UCSB scientists document fate of huge oil slicks from seeps at coal oil point 3UCSB scientists document fate of huge oil slicks from seeps at coal oil point 4Association for Molecular Pathology joins ACLU to challenge gene patents 2
(Date:9/17/2014)... JH Technologies announces the grand opening ... JH Technologies, a leader in sales and support of ... partnership with Leica Microsystems into the Southern California market. ... will be featured at the grand opening slated for ... is located within the JH Technologies office’s at 18025 ...
(Date:9/17/2014)... September 17, 2014 Terracon Corporation has ... its TerraPure tank . This addition to the ... from FDA-compliant linear polyethylene and available in 125 or ... and ships in two weeks or less. , The ... benefits found in Terracon’s existing TerraPure tank line – ...
(Date:9/17/2014)... , Sept. 17, 2014 Alternative Fuels Americas, Inc. ... form a Special Purpose Vehicle in partnership with Jatro Greentech, ... agro energy company. The SPV shall be called AFAI Jatro ... AFAI as majority shareholder. The SPV shall pursue Jatropha planting ... particularly Ethiopia . "Although ...
(Date:9/17/2014)... RXi Pharmaceuticals Corporation (NASDAQ: ... developing and commercializing innovative therapies addressing major unmet ... has been granted a patent by the United ... delivery system for delivering its "original" RNAi compounds ... treatment of diseases with an inflammatory component. Potential ...
Breaking Biology Technology:JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3Terracon Introduces Pre-Engineered TerraPure® Tank for Ultrapure Water Applications 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 2RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 4
... Senomyx, Inc. (Nasdaq: SNMX ), a leading company ... and develop novel flavor ingredients for the food, beverage, ... the Company,s President and Chief Operating Officer, will present ... p.m. Pacific Time (4:30 p.m. Eastern Time) during the ...
... ... a leading organization dedicated to pricing strategy and pricing research globally and Vendavo®, a ... the Vendavo,s Pricing Knowledge Series training programs are now eligible for credit in the ... ...
... Dr. scar Custance from the National Institute for Materials Science ... for Experimental Work in Nanotechnology for his research in atomic-scale ... lead to more effective catalysts for the production of hydrogen ... be awarded in January 2010 near Palo Alto, California along ...
Cached Biology Technology:SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE 2009 BIOCOM INVESTOR CONFERENCE 2Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 2Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 3Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 4Researcher honored for experimental work in nanotechnology 2
BD Falcon microtest assay plate. 1536 well 12l, black, flat-bottom PS. Polystyrene, nonsterile, no lid. (15/sp, 60/ca) Packaging: 15 / pack, 60 / case ...
... wall plates have low background fluorescence, ... Not treated (or medium binding) polystyrene ... binds biomolecules through passive interactions,• ... of large molecules, such as antibodies, ...
... The Model 1575 immunowash microplate washer, 100-240 ... that have flat-, U-, or V-bottom wells. ... vertical needle positions to an accuracy of ... and overflow washing. It can store up ...
... Incubator is a compact benchtop and ... microprocessor controller with a large display ... agitation speed. Air circulation inside to ... Temperature can be easily calibrated from ...
Biology Products: