Navigation Links
Failure of 'scout cells' may lead to cancer in transplant patients

me people have a normal genetic difference that causes them to have lower levels of IFNg in the body and others to have higher levels.

The researchers then injected white blood cells from each of the two groups of people into immune-deficient mice. All the people were healthy and tested positive for EBV.

They found that white blood cells from people who had the genetic difference for lower IFNgƒnlevels were more likely to cause EBV-related cancer in the mice than cells from people with the genetic difference for higher IFNg levels. They also found that blocking TGFb prevented the EBV-related cancer.

We hypothesize that the balance between IFNgƒnand TGFb is probably important in determining whether or not the cancer develops, VanBuskirk says.

In the new study, for example, adding IFNg to TGFb prevented the scout cells from changing and allowed them to strongly re-stimulate the memory T cells.

If our hypothesis proves to be true, VanBuskirk says, it may one day be possible to identify transplant patients who are at greater risk for PTLD and to develop new therapies that prevent or treat the disease.


'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Implanted Devices Detect High-Risk Heart Failure Patients
2. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
3. Failure to meet United Nations sanitation target could affect millions of the worlds poorest
4. Two chemicals boost immune cells ability to fight HIV without gene therapy
5. Once given no respect, cells tiny RNAS take drivers seat
6. How HIV disables the cells call for help
7. Stem cells electric abilities might help their safe clinical use
8. Scientists discover the molecular switch for nerve cells insulating jelly rolls
9. New insight into machinery of immune cells tentacles
10. Allergy cells can aggravate cancer and psoriasis
11. A key antibody, IgG, links cells capture and disposal of germs
Post Your Comments:
Breaking Biology News(10 mins):Type 2 diabetes gene predisposes children to obesity 2New understanding of how to prevent destruction of a tumor suppressor 2Biogen Idec's oral compound BG-12 achieves development milestones in MS and RA 2Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 1Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 2Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 3Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 4Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 5Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 6Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 7Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 8Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 9Robbins 26amp 3B Myers Announces Fourth Quarter and Full Year 2009 Results 5236 10Mercury in Fish Linked to High Blood Pressure 58897 1Mercury in Fish Linked to High Blood Pressure 58897 2Mercury in Fish Linked to High Blood Pressure 58897 3Antidepressants May Be Linked to Birth Problems 58893 1Antidepressants May Be Linked to Birth Problems 58893 2