Navigation Links
FSU biologists describe key role of signal-transcribing gene during cell cycle

Study in Oct. 1 'Development' shows when, where Alzheimer's, some cancers and genetic ills beginT. Biologists at Florida State University have uncovered the pivotal role of a gene called "Cut" that acts as a sort of middleman in cell-to-cell communication.

A DNA-binding protein, Cut interprets and transcribes the developmental signals sent through the "Notch" gene, which regulates a layer of epithelial cells as they replicate and divide. But when Cut garbles those signals the result is uncontrolled cell proliferation, sometimes with dire genetic and health consequences.

Results of the study are described in the Oct. 1 edition of the journal Development.

Led by FSU assistant professor Wu-Min Deng, the research has provided a more precise understanding of just how and where molecular mechanisms that drive cell cycle behavior and fate go wrong along the critical Notch pathway ?? a communication channel already associated with the genesis of several genetic and neuromuscular diseases; the most common complex congenital heart disorder; and later life ills such as Alzheimer's, breast and lung cancer, and leukemia.

"We now know that the transcription factor Cut is the key there," said Deng.

Assisted by FSU graduate student and co-author Jianjun Sun, Deng conducted the study using the powerful Drosophila (fruit fly) genetic model. Over the course of a year, they tracked the cell-to-cell communication in Drosophila egg chambers that control cell proliferation.

"We believe the specific cell-to-cell signaling and dysfunction observed in fruit flies is applicable to mammals, which also possess genes Notch and Cut," said Deng.

The researchers traced the journey of transmissions originating from Notch ?? which carries information gleaned from other cells ?? following the signals down the Notch pathway as Cut linked them to the control of cell proliferation in the egg chambers, which they observed at different stages.

When Cut accurately transcribed the Notch signals, the cells progressed appropriately from the conventional mitosis (replication and division) to the specialized endocycle, where cells cease division but still replicate their DNA.

But if Notch-to-Cut communication and Cut transcription were dysfunctional, so, too, was the cell cycle. In that case, the essential switch from mitosis to the endocycle failed, resulting in unregulated growth.

According to Deng, knowing exactly how and where in the Notch pathway early developmental signals get crossed may be crucial to future fixes, since mutations to the molecular mechanisms there are linked in humans to specific congenital and later life disorders.

"With further study, these findings may aid the development of interventions that target certain diseases precisely where and when they begin at the molecular level," he said.

Deng's focus on Cut since joining the biological sciences faculty at FSU in 2004 followed a Notch study he also co-authored, which appeared in a 2001 issue of Development.


'"/>

Source:Florida State University


Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. NYU biologists map out early stages of embryo formation
4. High-tech tags on marine animals yield valuable data for biologists and oceanographers
5. UCSD biologists find new evidence for one-way evolution
6. UC San Diego biologists solve plant growth hormone enigma
7. FSU biologists uncover mechanisms that shape cells for better or worse
8. NYU biologists identify gene that coordinates two cellular processes
9. MIT biologists solve vitamin puzzle
10. Yale biologists trick viruses into extinction
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)...   ivWatch LLC , a medical device company focused on ... receipt of its ISO 13485 Certification, the global standard for medical ... Standardization (ISO®). ... Continuous Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as ...
(Date:5/23/2017)... GENOA, Italy , May 23, 2017  Hunova, the first robotic ... and trunk, has been officially launched in Genoa, Italy ... Europe and the USA . The ... launched on the market by the IIT spin-off Movendo Technology thanks to ... view the Multimedia News Release, please click: ...
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They call it the ... network, a depiction of a system of linkages and connections so complex and ... professor of computer science at Worcester Polytechnic Institute (WPI) and director of the ...
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded ... of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for ... fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates ...
(Date:10/11/2017)... YORBA LINDA, CA (PRWEB) , ... October 11, ... ... adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and ... activation (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
Breaking Biology Technology: