Navigation Links
FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

At first, we thought that gene expression was modulated only by transcription factors. Then we found that the RNA resulting from transcription could be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at the RNA level is even more complex than we first imaginated...

As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ways to control gene expression, the trick for players in this game is to recognize them amidst the incredibly complex background of cellular machinery.

Now, in a paper in the January 28th issue of Cell, Lynne E. Maquat, Ph.D., professor of Biochemistry and Biophysics at the University of Rochester Medical Center, and her team have identified a novel pathway for RNA degradation, a form of regulation that has garnered significant attention in recent years, and one that has the potential to produce a new set of tools for physicians to use to fight disease.

Most of the gene-control tools researchers have collected thus far involve the first step in gene expression, in which DNA is copied into RNA transcripts. However, recent discoveries have shown that many of the tools cells use to regulate genes work after transcription, by moderating the activity and the life span of the RNA itself.

One major pathway for such post-transcriptional regulation is called nonsense-mediated decay (NMD). Originally NMD was thought to destroy incorrectly transcribed or otherwise problematic RNAs, but investigators now know that it plays a major role in regulating the life span of numerous RNAs, and thus controls gene activity.

To better understand what controls the NMD system, Maquat and her postdoctoral fellow, Yoon Ki Kim, Ph.D., used a critical c
'"/>

Source:


Page: 1 2 3

Related biology news :

1. FDA Approves New Drug to Treat Type I and Type II Diabetes
2. FDA Approves New Treatment for Chronic Hepatitis B
3. New Clues Add 40,000 Years to Age of Human Species
4. Human Cells Filmed Instantly Messaging for First Time
5. Govt Creates Gene Database of Normal Human Tissues
6. Analysis Of Human Genome To Predict The Development Of Illnesses
7. Human Eggs Can Develop From Ovarian Surface Cells In Vitro
8. Determining The Fate Of Cells In The Human Body
9. Whole genome promoter mapping - Human Genome Project v2.0?
10. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
11. Going To Extremes To Improve Human Health
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: FDA Approves Human Hookworm Vaccine for Phase Safety Trials

(Date:10/15/2014)... a non-traditional biophysics textbook and it describes how life ... of discovery into biological systems and provides an understanding ... is about how our genes make proteins that control ... cells in an organism. It quantifies the principles of ... be found on both large and small scales. The ...
(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
(Date:10/14/2014)... have sequenced the house fly genome for the first ... from an insect that thrives in pathogen-rich dung piles ... in the journal Genome Biology , will increase ... how flies quickly adapt to resist insecticides, which could ... (Musca domestica) carry and transmit more than 100 human ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2
... of American Societies for Experimental Biology (FASEB) announces ... Conference (SRC): Matricellular Proteins in Development, Health, and ... extracellular matrix (ECM) are the basis for multi-cellular ... in all metazoan organisms. Structural ECM components such ...
... Societies for Experimental Biology (FASEB) announces the opening ... Mechanisms in Plant Development Conference. The 2013 ... and unique scientific conference where the intersections of ... through formal talks, poster sessions, and intensive scientific ...
... Two wasp species , Calymmochilus dispar and ... on ant-eating spiders in a study published in the ... spider, Zodarion styliferum , belongs to the largest genus ... and North Africa, significantly with at least 35 species reported ...
Cached Biology News:FASEB SRC announces conference: Matricellular Proteins in Development, Health, and Disease 2Survival of the fittest: Predator wasps breed at the expense of spider juveniles 2
(Date:10/19/2014)... NextCODE Health, which enables clinicians and researchers to ... today announced the launch of its new genomic data analysis ... American Society of Human Genetics (ASHG) annual meeting in ... and apply for free beta access, visit www.nextcode.com . ... be viewed here . The Exchange: ...
(Date:10/19/2014)... October 19, 2014 The report "Chocolate, ... Share, Trade, Prices, Geography Trend and Forecast (2011 - ... category, and geography and studies the major market drivers, ... America, Europe, and Asia. , The global chocolate market ... $98.3 billion in 2016 at an estimated CAGR of ...
(Date:10/18/2014)... October 19, 2014 The “Human ... Acting, Intermediate Acting, Premixed), Modern Human Insulin (Rapid ... Levemir, NovoRapid, Novomix, Tresiba, Others) - Forecast to ... drivers, restraints, challenges, opportunities, current market trends, and ... with the estimates and forecasts of the revenue ...
(Date:10/18/2014)... The Asia-Pacific hardware encryption display market report defines and ... forecast of revenue. This market was valued $5,154.0 million ... by 2018, at a CAGR of 58.4% from 2013 ... Asia-Pacific hardware encryption market report, to get an idea ... glimpse of the segmentation of the market, and is ...
Breaking Biology Technology:The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3
... busy at the BIO Chicago industry show this week. Rather ... pen or kangaroo lapel pin, he met with more than ... mostly in prearranged sessions designed to help attendees make the ... of NeoClone , which manufactures monoclonal antibodies. It was ...
... some prominent customers led to a new high in ... of 2006, the company reported Wednesday. , ,Specific figures ... quarter by exceeding expectations in license sales, services business, ... established in the fourth quarter of 2005. The company ...
... representatives from Japan, the second-largest biotech market in ... BIO convention, you might not think they would ... a show of Wisconsin's international partnerships in biotechnology, ... at the Japan international session. And speaker Tsuney ...
Cached Biology Technology:Partner program is highlight of BIO for Wisconsin firm 2Japanese delegates highlight Wisconsin at BIO Chicago 2Japanese delegates highlight Wisconsin at BIO Chicago 3
... Vector NTI Advance 9.1 ... and highly integrated application ... and molecular biology data ... readily available for export. ...
... 50mM Tris-HCl, pH 7.5, 0.1mM ... 1mM benzamidine, 0.1% 2-mercaptoethanol and ... Phosphatase 2A1) partially purified enzyme ... QSepharose,amino-hexyl agarose, Superdex 200, and ...
Whole blood is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -...
... vitro cell labeling mix, 92.5 ... solution stabilized with 0.1% 2-mercaptoethanol ... 3,4-dicarboxylic acid. *Amino acid mixture ... containing l-[35S]Methionine and l-[35S]Cysteine. * ...
Biology Products: