Navigation Links
Extra-aggressive form of idiopathic pulmonary fibrosis identified

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disorder from which most patients die within 5 years after diagnosis. The disease is characterized by the insidious onset of dyspnea or cough and usually evolves slowly.

Now, Selman and coworkers present in an article published in the online, open-access journal PLoS ONE on Wednesday 30th May, strong evidence indicating that a subset of IPF patients has a short duration of symptoms before diagnosis and display an accelerated clinical course to end-stage disease. The authors postulate that these "rapid progressor" patients, predominantly smoking males, represent a distinct clinical phenotype compared with the usual "slow progressors" patients.

"These findings highlight the variability in the progression and outcome of IPF, and may explain, in part, the difficulty in obtaining significant and reproducible results in studies of therapeutic interventions in patients with IPF," said Dr Selman, who is the Director of Research at the National Institute of Respiratory Research in Mexico City and the lead author on this publication. "They also suggest that physicians should pay more attention to the time of onset of symptoms, and to look for other signs that allow the identification of these rapid progressor patients".

In this study the authors performed global gene expression analysis and other molecular studies in a subset of patients and identified a number of genes that were differentially expressed in both groups, suggesting that rapid progressors are biologically distinct from slow progressors.

"While preliminary, these results may allow investigators to identify biomarkers of disease progression," said Dr King, who is the Chief of Medicine at San Francisco General Hospital and an internationally renowned expert in research and management of pulmonary fibrosis.

The senior author on this paper, Dr Naftali Kaminski, who is the Director of
'"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
2. Study: Predatory dinosaurs had bird-like pulmonary system
3. Researchers develop gene therapy to reverse pulmonary arterial hypertension
4. Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
5. Scientists discover basic defect in cystic fibrosis airway glands
6. Study reveals how cells destroy faulty proteins in cystic fibrosis
7. Discovery could aid fight against cystic fibrosis infection
8. Clues to gene expression in cystic fibrosis will guide research
9. Key found to kill cystic fibrosis superbug
10. Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
11. Source of molecular triggers in cutaneous T cell lymphoma identified
Post Your Comments:
(Date:6/23/2015)... , June 23, 2015   Valencell, ... announced the results of a recent study that ... on the wrist during activity. In a study ... was compared along with the Apple Watch against ... measuring heart rate during activity. The study demonstrated ...
(Date:6/17/2015)... Maryland , and HILDEN, Germany , ... QGEN ; Frankfurt Prime Standard: QIA) today launched new ... evidence in forensic laboratories in the United States ... solution to simultaneously analyze multiple key genomic markers (short tandem ... ® Quality Sensor to evaluate the quality of DNA ...
(Date:6/16/2015)... , June 16, 2015 Fingerprint Cards ... fingerprint sensors in the company,s portfolio from one of its ... planned to mainly take place during the third quarter 2015. ... Asia . Jörgen Lantto, CEO of ...   the   growing interest from smartphone OEMs in integrating ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2
... change the world has seen in the last 100,000 years ... interglacial period. New research from the Niels Bohr Institute at ... the rise in temperature and the rise in the atmospheric ... time. The results have been published in the scientific journal, ...
... new study finds that mice have a distinct neural ... is associated with instinctually important smells such as those ... in Proceedings of the National Academy of Sciences ... have specially hardwired neural circuitry to trigger instinctive behavior ...
... breeders announced a new high-yielding variety of oats. ... height, withstands falling over (lodging), matures earlier and produces ... seed yield potential, exceeding the Rodgers variety by 20 ... 32.2-pound bushel compared to 31.9-pound bushel for Rodgers," said ...
Cached Biology News:Rise in temperatures and CO2 follow each other closely in climate change 2Rise in temperatures and CO2 follow each other closely in climate change 3Mice have distinct subsystem to handle smell associated with fear 2Mice have distinct subsystem to handle smell associated with fear 3Clemson plant breeders roll out new oat variety 2
(Date:7/2/2015)... ... July 02, 2015 , ... Sleepless nights will become obsolete as ... launched its Indiegogo campaign on June 23. Sound sleepers and the sleep deprived both ... effortless to use, while the integration of the Bluetooth speaker, alarm clock and ability ...
(Date:7/1/2015)... ... , ... The next-generation sequencing (NGS) clinical market is poised for huge growth ... BCC Research reveals in its new report that the market drivers of this vibrant ... need for better diagnostics as part of a molecular diagnostics trend. , The global ...
(Date:7/1/2015)... ... July 01, 2015 , ... A newly launched business plan contest will ask ... to innovation in life sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 will ... and a period of expert mentorship from a senior industry figure drawn from the ...
(Date:6/30/2015)... Japan , July 1, 2015 R-Japan Co.,Ltd. ... on the Safety of Regenerative Medicine from the Ministry of ... on June 29, 2015. The fact that ... processing facility through the auditing from Pharmaceuticals and Medical Devices ... the application, allows it to provide stem cell manufacturing service ...
Breaking Biology Technology:Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2
... ANN ARBOR, Mich. A novel technique for vaccinating ... oil-based emulsion placed in the nose, rather than needles ... response against smallpox and HIV in two new studies. ... studies with a nasal nanoemulsion vaccine for influenza, reported ...
... b3c newswire /   -  DuoCort AB announced ... Optimized Care for Adrenal Insufficiency – at the 10th ... Congress Centrum in Berlin.  The symposium will be held ... delegates attending ECE 2008 are invited to the symposium. ...
... that its,Chief Financial Officer, Rick McCook, will resign effective ... "I have enjoyed my work with US Oncology ... said McCook. "However, at this time I,intend to explore ... leverage my skills and experience.", "During his tenure ...
Cached Biology Technology:Nanoemulsion vaccines show increasing promise 2Nanoemulsion vaccines show increasing promise 3Nanoemulsion vaccines show increasing promise 4DuoCort Hosts Adrenal Insufficiency Symposium at the 10th European Congress of Endocrinology in Berlin 2
Rat neural stem cell kits are intended for the in vitro growth and commitment to neuronal and glial lineage differentiation, of cultured fetal rat neural stem and progenitor cells expanded using FGF-...
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
... Price (1996) • This issue ... chemistry and the purification and ... on the following procedures is ... amino acid analysis and the ...
... (1994) • This book describes the ... for preparing samples for protein transfer ... and bioluminescence-enhanced detection systems are also ... detection and characterization of glycoprotein carbohydrate ...
Biology Products: