Navigation Links
Exploring the dark matter of the genome

tion to the next."

Says Smith, "The heterochromatin is where transposons may be actively regulated -- they go in, get stuck, and get chopped up. Other researchers have shown that small interfering RNAs are made in the heterochromatin, which seek out transposons and inactivate them. That's the kind of knowledge that comes from sequencing heterochromatin."

Smith uses the metaphor of dark matter to suggest the significance of heterochromatin. "We don't know what holds the galaxies together, and the same is true of the genome. We're pretty good at understanding how individual genes work, but we don't understand, for example, how the large-scale structure of genomes affects cellular processes. We hear too much about the 'post-genomic era' -- it's underappreciated that we don't understand the genome yet."

Celniker agrees. "What we would like to see is a complete sequence of the fruit fly from telomere to telomere" -- that is, from one end of the chromosomes to the other -- including the centromere in the middle." Obtaining a more complete picture of the sequence of heterochromatin is clearly a crucial step toward a better understanding of genome functions.

Karpen notes that one intensively studied and puzzling problem in chromosome biology will benefit enormously from the new findings: epigenetics -- the inheritance of traits and genetic information as controlled by proteins associated with the chromosomes, rather than by DNA sequence. Starting in the 1920s, epigenetics was discovered through biological studies of heterochromatin, and is now known to regulate essential functions such as those of the centromeres. The heterochromatin sequence of Drosophila will provide an essential foundation for identifying the proteins and components involved in epigenetic inheritance, as well as other mysteries surrounding the genome's "dark matter."

"Sequence finishing and mapping of Drosophila melanogaster heterochromatin," by
'"/>

Source:DOE/Lawrence Berkeley National Laboratory


Page: 1 2 3 4 5 6

Related biology news :

1. Exploring the molecular origin of blood clot flexibility
2. To sea or not to sea: When it comes to salmon sex, size sometimes doesnt matter
3. Size matters: Preventing large mammal extinction
4. Space matters: Estimating species diversity in the fossil record
5. Looks matter to female barn swallows
6. Bigger brain size matters for intellectual ability
7. UCSB researchers discover shape matters to macrophages
8. Researchers find that bumblebees flower choice matters
9. For Pacific white shrimp, gender matters when competing for food
10. Particle size matters to bacteria ability to immobilize heavy metals
11. Monitoring poisons in the environment -- a woolly matter
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Exploring the dark matter the genome

(Date:9/18/2014)... protective tentacles of host anemones, but new research shows ... across the open ocean. Although the process of long-distance ... the first time that the high level exchange of ... Steve Simpson, Senior Lecturer in Marine Biology and Global ... the Australian Research Council Centre of Excellence for Coral ...
(Date:9/17/2014)... UCLA atmospheric scientists were instrumental in the creation of ... tool to classify the fire threat potential of the ... a spark into an inferno. The index was introduced ... with UCLA and San Diego Gas and Electric. , ... to "extreme" that will be used to help fire ...
(Date:9/17/2014)... and his doctoral student have designed a device based ... from fog and dew., The device could provide water ... the globe., Cheng Luo, professor in the Mechanical & ... the same College of Engineering department, published "Bioinspired Plate-Based ... (American Chemical Society) Applied Materials & Interfaces ...
Breaking Biology News(10 mins):Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Shorebird's beak inspires UT Arlington research on water collection 2
... crystals, known to be a catalyst for heart attacks and ... can lead to the inflammation and hardening of arteries, according ... by George Abela, chief of the cardiology division in MSU,s ... new insights into how arteries harden a process called ...
... patches of woods in urban areas seem to provide adequate ... they fly between wintering and breeding grounds, new research has ... of cities worldwide, migrating landbirds increasingly must pass through vast ... on which many species rely. "The good news is ...
... N.Y. (May 18, 2010) -- Symmetry breaking events ... They are required for cell division, development, and movement ... Moreover, in multicellular organisms, symmetry breaking allows the generation ... arrangement of tissues and organs achieved during embryogenesis. ...
Cached Biology News:Cholesterol crystals incite inflammation in coronary arteries 2Even small patches of urban woods are valuable for migrating birds 2Even small patches of urban woods are valuable for migrating birds 3
(Date:9/18/2014)... , September 18, 2014 ... ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the ... - Global Strategic Business Report" ... http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the worldwide ... Million by the following Product Segments: ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global and Chinese Stem Cell Industry Report, 2014-2017" ... cells are undifferentiated biological cells that can differentiate into ... more stem cells. Stem cell therapy can be applied ... hematological system disease), nervous system diseases, damage or lesion ...
(Date:9/18/2014)... Research and Markets has announced ... Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & ... The global companion diagnostics market is expected ... to 2019. Factors such as rising need for personalized ... by the pharmaceutical industry, support from regulatory authorities, and ...
(Date:9/18/2014)... DIEGO , Sept. 18, 2014  MEI Pharma, Inc. ... the clinical development of novel therapies for cancer, announced today ... Executive Officer, will present at BioCentury,s NewsMakers in the ... 8:30 a.m. Eastern time from the Millennium Broadway Hotel & ... live webcast of the presentation can be accessed at ...
Breaking Biology Technology:Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3
... to Remain as Advisor to Company, FRAZER, Pa., ... its Executive Vice President, General Counsel &,Secretary, John E. ... effective March 31. Mr. Osborn has agreed to remain ... policy matters., "John has been an invaluable member ...
... Inc. (Nasdaq:,EVVV) will release its 2007 fourth quarter and ... market trading hours., The company will host a ... CT (8:30 a.m. ET). ev3 management will review its ... outlook, followed,by a question and answer session., The ...
... Spanish . , ANN ARBOR, Mich.---A new ... to operate a portable GPS locator, a cell phone, ... involving the University of Michigan shows. , A report ... issue of the journal Science. Authors include researchers from ...
Cached Biology Technology:Cephalon General Counsel John E. Osborn to Resign Position 2Cephalon General Counsel John E. Osborn to Resign Position 3ev3 Inc. to Report 2007 Fourth Quarter and Full-Year Financial Results and Host Conference Call on February 22, 2008 2Knee brace generates electricity from walking 2
... Pierce offers maleimide activated carrier proteins ... conjugates. Imject Maleimide Activated Carrier Proteins ... been preactivated with a heterobifunctional cross-linker ... stable, sulfhydryl-reactive carrier protein. Thus ...
...
... A perfect complement to high-speed analytical techniques, the AutoTrace SPE is a ... automates the cartridge conditioning, sample loading and elution steps for large volumes aqueous ... ... ...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
Biology Products: